Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: An immunohistochemical study in the rat
Ohishi H, Nomura S, Ding Y, Shigemoto R, Wada E, Kinoshita A, Li J, Neki A, Nakanishi S, Mizuno N. 1995. Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: An immunohistochemical study in the rat. Neuroscience Letters. 202(1–2), 85–88.
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Journal Article
| Published
| English
Author
Ohishi, Hitoshi;
Nomura, Sakashi;
Ding, Yu;
Shigemoto, RyuichiISTA 
;
Wada, Eiki;
Kinoshita, Ayae;
Li, Jin;
Neki, Akio;
Nakanishi, Shigetada;
Mizuno, Noboru
;
Wada, Eiki;
Kinoshita, Ayae;
Li, Jin;
Neki, Akio;
Nakanishi, Shigetada;
Mizuno, NoboruAbstract
An antibody which recognizes specifically a metabotropic glutamate receptor, mGluR7, was produced by using a trpE fusion protein containing a C-terminal sequence of rat mGluR7. Neuropil in laminae I and II of the dorsal horn of the rat, as well as many neuronal cell bodies in the dorsal root ganglion, showed mGluR7-like immunoreactivity; the immunoreactivity in neuropil was seen in axon terminals, which were filled with round synaptic vesicles and constituted axodendritic and axosomatic asymmetric synapses. The mGluR7-like immunoreactivity in laminae I and II in the dorsal horn was reduced after dorsal rhizotomy. The results indicate that some axon terminals of the primary afferent fibers to laminae I and II of the dorsal horn are provided with mGluR7.
Publishing Year
Date Published
1995-12-01
Journal Title
Neuroscience Letters
Acknowledgement
We are grateful to Mr. Akira Uesugi for photographic help.
Volume
202
Issue
1-2
Page
85 - 88
ISSN
IST-REx-ID
Cite this
Ohishi H, Nomura S, Ding Y, et al. Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: An immunohistochemical study in the rat. Neuroscience Letters. 1995;202(1-2):85-88. doi:10.1016/0304-3940(95)12207-9
Ohishi, H., Nomura, S., Ding, Y., Shigemoto, R., Wada, E., Kinoshita, A., … Mizuno, N. (1995). Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: An immunohistochemical study in the rat. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(95)12207-9
Ohishi, Hitoshi, Sakashi Nomura, Yu Ding, Ryuichi Shigemoto, Eiki Wada, Ayae Kinoshita, Jin Li, Akio Neki, Shigetada Nakanishi, and Noboru Mizuno. “Presynaptic Localization of a Metabotropic Glutamate Receptor, MGluR7, in the Primary Afferent Neurons: An Immunohistochemical Study in the Rat.” Neuroscience Letters. Elsevier, 1995. https://doi.org/10.1016/0304-3940(95)12207-9.
H. Ohishi et al., “Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: An immunohistochemical study in the rat,” Neuroscience Letters, vol. 202, no. 1–2. Elsevier, pp. 85–88, 1995.
Ohishi H, Nomura S, Ding Y, Shigemoto R, Wada E, Kinoshita A, Li J, Neki A, Nakanishi S, Mizuno N. 1995. Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: An immunohistochemical study in the rat. Neuroscience Letters. 202(1–2), 85–88.
Ohishi, Hitoshi, et al. “Presynaptic Localization of a Metabotropic Glutamate Receptor, MGluR7, in the Primary Afferent Neurons: An Immunohistochemical Study in the Rat.” Neuroscience Letters, vol. 202, no. 1–2, Elsevier, 1995, pp. 85–88, doi:10.1016/0304-3940(95)12207-9.
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