Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry

Kawakami R, Shinohara Y, Kato Y, Sugiyama H, Shigemoto R, Ito I. 2003. Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry, American Association for the Advancement of Science,p.

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DOI
10.1126/science.1082609
Report | Published | English

Scopus indexed
Author
Kawakami, Ryosuke; Shinohara, Yoshiaki; Kato, Yuichiro; Sugiyama, Hiroyuki; Shigemoto, RyuichiISTA ; Ito, Isao
Abstract
Despite its implications for higher order functions of the brain, little is currently known about the molecular basis of left-right asymmetry of the brain. Here we report that synaptic distribution of N-methyl-D-aspartate (NMDA) receptor GluRε2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between the left and right and between the apical and basal dendrites of single neurons. These asymmetrical allocations of ε2 subunits differentiate the properties of NMDA receptors and synaptic plasticity between the left and right hippocampus. These results provide a molecular basis for the structural and functional asymmetry of the mature brain.
Publishing Year
2003
Date Published
2003-05-09
Publisher
American Association for the Advancement of Science
Volume
300
Page
990 - 994
ISSN
0036-8075
eISSN
1095-9203
IST-REx-ID
2627

Cite this

Kawakami R, Shinohara Y, Kato Y, Sugiyama H, Shigemoto R, Ito I. Asymmetrical Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry. Vol 300. American Association for the Advancement of Science; 2003:990-994. doi:10.1126/science.1082609
Kawakami, R., Shinohara, Y., Kato, Y., Sugiyama, H., Shigemoto, R., & Ito, I. (2003). Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry (Vol. 300, pp. 990–994). American Association for the Advancement of Science. https://doi.org/10.1126/science.1082609
Kawakami, Ryosuke, Yoshiaki Shinohara, Yuichiro Kato, Hiroyuki Sugiyama, Ryuichi Shigemoto, and Isao Ito. Asymmetrical Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry. Vol. 300. American Association for the Advancement of Science, 2003. https://doi.org/10.1126/science.1082609.
R. Kawakami, Y. Shinohara, Y. Kato, H. Sugiyama, R. Shigemoto, and I. Ito, Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry, vol. 300. American Association for the Advancement of Science, 2003, pp. 990–994.
Kawakami R, Shinohara Y, Kato Y, Sugiyama H, Shigemoto R, Ito I. 2003. Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry, American Association for the Advancement of Science,p.
Kawakami, Ryosuke, et al. Asymmetrical Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry. Vol. 300, American Association for the Advancement of Science, 2003, pp. 990–94, doi:10.1126/science.1082609.

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