A role for Neuregulin1 signaling in muscle spindle differentiation
Hippenmeyer S, Shneider N, Birchmeier C, Burden S, Jessell T, Arber S. 2002. A role for Neuregulin1 signaling in muscle spindle differentiation. Neuron. 36(6), 1035–1049.
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Journal Article
| Published
| English
Scopus indexed
Author
Hippenmeyer, SimonISTA 
;
Shneider, Neil;
Birchmeier, Carmen;
Burden, Steven;
Jessell, Thomas;
Arber, Silvia
;
Shneider, Neil;
Birchmeier, Carmen;
Burden, Steven;
Jessell, Thomas;
Arber, SilviaAbstract
The maturation of synaptic structures depends on inductive interactions between axons and their prospective targets. One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles. We have monitored the expression of three transcription factors, Egr3, Pea3, and Erm, that delineate early muscle spindle development in an assay of muscle spindle-inducing signals. We provide genetic evidence that Neuregulin1 (Nrg1) is required for proprioceptive afferent-evoked induction of muscle spindle differentiation in the mouse. Ig-Nrg1 isoforms are preferentially expressed by proprioceptive sensory neurons and are sufficient to induce muscle spindle differentiation in vivo, whereas CRD-Nrg1 isoforms are broadly expressed in sensory and motor neurons but are not required for muscle spindle induction.
Publishing Year
Date Published
2002-12-19
Journal Title
Neuron
Publisher
Elsevier
Acknowledgement
We thank L. Role for generously providing the CRD-Nrg1 mutant allele for these studies, L. Parada and D. Anderson for sharing the TrkC and Ngn1 mouse strains, W. Tourtellotte for providing Egr3 mutant mice, E. Avetisova for expert technical assistance, X. Yang for experimental help in the initial phase of these studies, A. Garratt for advice with ErbB antibodies, and L. Role and G. Fischbach for helpful discussions. The CRD-Nrg1 mutant allele was generated in the lab of Dr. Lorna Role, with the support of NIH grant NS29071. S.A. and S.H. were supported by a grant from the Swiss National Science Foundation and the Kanton of Basel-Stadt. S.J.B. was supported by grants from the NINDS. N.A.S. was supported by a Howard Hughes Medical Institute Postdoctoral Fellowship for Physicians and a Career Development Award from the NINDS. T.M.J. was supported by grants from NINDS and is an Investigator of the Howard Hughes Medical Institute.
Volume
36
Issue
6
Page
1035 - 1049
ISSN
IST-REx-ID
Cite this
Hippenmeyer S, Shneider N, Birchmeier C, Burden S, Jessell T, Arber S. A role for Neuregulin1 signaling in muscle spindle differentiation. Neuron. 2002;36(6):1035-1049. doi:10.1016/S0896-6273(02)01101-7
Hippenmeyer, S., Shneider, N., Birchmeier, C., Burden, S., Jessell, T., & Arber, S. (2002). A role for Neuregulin1 signaling in muscle spindle differentiation. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(02)01101-7
Hippenmeyer, Simon, Neil Shneider, Carmen Birchmeier, Steven Burden, Thomas Jessell, and Silvia Arber. “A Role for Neuregulin1 Signaling in Muscle Spindle Differentiation.” Neuron. Elsevier, 2002. https://doi.org/10.1016/S0896-6273(02)01101-7.
S. Hippenmeyer, N. Shneider, C. Birchmeier, S. Burden, T. Jessell, and S. Arber, “A role for Neuregulin1 signaling in muscle spindle differentiation,” Neuron, vol. 36, no. 6. Elsevier, pp. 1035–1049, 2002.
Hippenmeyer S, Shneider N, Birchmeier C, Burden S, Jessell T, Arber S. 2002. A role for Neuregulin1 signaling in muscle spindle differentiation. Neuron. 36(6), 1035–1049.
Hippenmeyer, Simon, et al. “A Role for Neuregulin1 Signaling in Muscle Spindle Differentiation.” Neuron, vol. 36, no. 6, Elsevier, 2002, pp. 1035–49, doi:10.1016/S0896-6273(02)01101-7.
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