A small number of open Ca(2+) channels trigger transmitter release at a central GABAergic synapse
Bucurenciu I, Bischofberger J, Jonas PM. 2010. A small number of open Ca(2+) channels trigger transmitter release at a central GABAergic synapse. Nature Neuroscience. 13(1), 19–21.
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DOI
Journal Article
| Published
Author
Bucurenciu, Iancu;
Bischofberger, Josef;
Jonas, Peter MISTA 
Abstract
To determine the number of open Ca(2+) channels necessary for transmitter release at the inhibitory basket cell-granule cell synapse in rat hippocampus, we combined presynaptic Ca(2+) imaging, recording of postsynaptic currents and modeling. We found that that the opening of three or fewer Ca(2+) channels triggered transmitter release. Furthermore, a small number of Ca(2+) channels were able to evoke release with high temporal precision, despite stochastic Ca(2+) channel opening.
Publishing Year
Date Published
2010-01-01
Journal Title
Nature Neuroscience
Publisher
Nature Publishing Group
Volume
13
Issue
1
Page
19 - 21
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Bucurenciu I, Bischofberger J, Jonas PM. A small number of open Ca(2+) channels trigger transmitter release at a central GABAergic synapse. Nature Neuroscience. 2010;13(1):19-21. doi:10.1038/nn.2461
Bucurenciu, I., Bischofberger, J., & Jonas, P. M. (2010). A small number of open Ca(2+) channels trigger transmitter release at a central GABAergic synapse. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.2461
Bucurenciu, Iancu, Josef Bischofberger, and Peter M Jonas. “A Small Number of Open Ca(2+) Channels Trigger Transmitter Release at a Central GABAergic Synapse.” Nature Neuroscience. Nature Publishing Group, 2010. https://doi.org/10.1038/nn.2461 .
I. Bucurenciu, J. Bischofberger, and P. M. Jonas, “A small number of open Ca(2+) channels trigger transmitter release at a central GABAergic synapse,” Nature Neuroscience, vol. 13, no. 1. Nature Publishing Group, pp. 19–21, 2010.
Bucurenciu I, Bischofberger J, Jonas PM. 2010. A small number of open Ca(2+) channels trigger transmitter release at a central GABAergic synapse. Nature Neuroscience. 13(1), 19–21.
Bucurenciu, Iancu, et al. “A Small Number of Open Ca(2+) Channels Trigger Transmitter Release at a Central GABAergic Synapse.” Nature Neuroscience, vol. 13, no. 1, Nature Publishing Group, 2010, pp. 19–21, doi:10.1038/nn.2461 .
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