The role of cell adhesion and contractility for germ layer morphogenesis during zebrafish gastrulation

We are interested in the cellular and molecular mechanisms underlying tissue morphogenesis during zebrafish gastrulation. Both differential cell adhesion and contractility have been proposed to be key mechanisms by which tissues form and rearrange in development. To obtain insight into the potential roles of differential cell adhesion and contraction for germ layer morphogenesis during gastrulation, we are analyzing cell adhesion and contraction of germ layer progenitor cells using atomic force microscopy, primary tissue culture and transplantation assays. I will present and discuss data about the differential adhesiveness and contractility of germ layer progenitor cells in the context of germ layer formation during vertebrate gastrulation.