Nested genes and increasing organizational complexity of metazoan genomes
Assis R, Kondrashov A, Koonin E, Kondrashov F. 2008. Nested genes and increasing organizational complexity of metazoan genomes. Trends in Genetics. 24(10), 475–478.
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Journal Article
| Published
Author
Assis, Raquel;
Kondrashov, Alexey S;
Koonin, Eugene V;
Kondrashov, FyodorISTA 
Abstract
The most common form of protein-coding gene overlap in eukaryotes is a simple nested structure, whereby one gene is embedded in an intron of another. Analysis of nested protein-coding genes in vertebrates, fruit flies and nematodes revealed substantially higher rates of evolutionary gains than losses. The accumulation of nested gene structures could not be attributed to any obvious functional relationships between the genes involved and represents an increase of the organizational complexity of animal genomes via a neutral process.
Publishing Year
Date Published
2008-10-01
Journal Title
Trends in Genetics
Volume
24
Issue
10
Page
475 - 478
IST-REx-ID
Cite this
Assis R, Kondrashov A, Koonin E, Kondrashov F. Nested genes and increasing organizational complexity of metazoan genomes. Trends in Genetics. 2008;24(10):475-478. doi:10.1016/j.tig.2008.08.003
Assis, R., Kondrashov, A., Koonin, E., & Kondrashov, F. (2008). Nested genes and increasing organizational complexity of metazoan genomes. Trends in Genetics. Elsevier. https://doi.org/10.1016/j.tig.2008.08.003
Assis, Raquel, Alexey Kondrashov, Eugene Koonin, and Fyodor Kondrashov. “Nested Genes and Increasing Organizational Complexity of Metazoan Genomes.” Trends in Genetics. Elsevier, 2008. https://doi.org/10.1016/j.tig.2008.08.003.
R. Assis, A. Kondrashov, E. Koonin, and F. Kondrashov, “Nested genes and increasing organizational complexity of metazoan genomes,” Trends in Genetics, vol. 24, no. 10. Elsevier, pp. 475–478, 2008.
Assis R, Kondrashov A, Koonin E, Kondrashov F. 2008. Nested genes and increasing organizational complexity of metazoan genomes. Trends in Genetics. 24(10), 475–478.
Assis, Raquel, et al. “Nested Genes and Increasing Organizational Complexity of Metazoan Genomes.” Trends in Genetics, vol. 24, no. 10, Elsevier, 2008, pp. 475–78, doi:10.1016/j.tig.2008.08.003.
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