Cell migration driven by cooperative substrate deformation patterns
Angelini T, Hannezo EB, Trepat X, Fredberg J, Weitz D. 2010. Cell migration driven by cooperative substrate deformation patterns. Physical Review Letters. 104(16).
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Journal Article
| Published
| English
Author
Angelini, Thomas;
Hannezo, Edouard ISTA 
;
Trepat, Xavier;
Fredberg, Jeffrey;
Weitz, David
;
Trepat, Xavier;
Fredberg, Jeffrey;
Weitz, DavidAbstract
Most eukaryotic cells sense and respond to the mechanical properties of their surroundings. This can strongly influence their collective behavior in embryonic development, tissue function, and wound healing. We use a deformable substrate to measure collective behavior in cell motion due to substrate mediated cell-cell interactions. We quantify spatial and temporal correlations in migration velocity and substrate deformation, and show that cooperative cell-driven patterns of substrate deformation mediate long-distance mechanical coupling between cells and control collective cell migration.
Publishing Year
Date Published
2010-04-23
Journal Title
Physical Review Letters
Acknowledgement
This work was supported by the NSF (DMR-0602684) and the Harvard MRSEC (DMR-0820484).
We would like to thank Dr. James Butler for helpful conversations.
Volume
104
Issue
16
IST-REx-ID
Cite this
Angelini T, Hannezo EB, Trepat X, Fredberg J, Weitz D. Cell migration driven by cooperative substrate deformation patterns. Physical Review Letters. 2010;104(16). doi:10.1103/PhysRevLett.104.168104
Angelini, T., Hannezo, E. B., Trepat, X., Fredberg, J., & Weitz, D. (2010). Cell migration driven by cooperative substrate deformation patterns. Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.104.168104
Angelini, Thomas, Edouard B Hannezo, Xavier Trepat, Jeffrey Fredberg, and David Weitz. “Cell Migration Driven by Cooperative Substrate Deformation Patterns.” Physical Review Letters. American Physical Society, 2010. https://doi.org/10.1103/PhysRevLett.104.168104.
T. Angelini, E. B. Hannezo, X. Trepat, J. Fredberg, and D. Weitz, “Cell migration driven by cooperative substrate deformation patterns,” Physical Review Letters, vol. 104, no. 16. American Physical Society, 2010.
Angelini T, Hannezo EB, Trepat X, Fredberg J, Weitz D. 2010. Cell migration driven by cooperative substrate deformation patterns. Physical Review Letters. 104(16).
Angelini, Thomas, et al. “Cell Migration Driven by Cooperative Substrate Deformation Patterns.” Physical Review Letters, vol. 104, no. 16, American Physical Society, 2010, doi:10.1103/PhysRevLett.104.168104.
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