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54 Publications
2021 | Published | Journal Article | IST-REx-ID: 15274 | 
Khalfaoui-Hassani B, Trasnea PI, Steimle S, Koch H-G, Daldal F. Cysteine mutants of the major facilitator superfamily-type transporter CcoA provide insight into copper import. mBio. 2021;12(4). doi:10.1128/mbio.01567-21
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2021 | Published | Journal Article | IST-REx-ID: 10310 |
Çoruh MO, Frank A, Tanaka H, et al. Cryo-EM structure of a functional monomeric Photosystem I from Thermosynechococcus elongatus reveals red chlorophyll cluster. Communications Biology. 2021;4(1). doi:10.1038/s42003-021-01808-9
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2021 | Published | Journal Article | IST-REx-ID: 9205 |
Kampjut D, Steiner J, Sazanov LA. Cryo-EM grid optimization for membrane proteins. iScience. 2021;24(3). doi:10.1016/j.isci.2021.102139
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2021 | Published | Journal Article | IST-REx-ID: 10146
Vercellino I, Sazanov LA. Structure and assembly of the mammalian mitochondrial supercomplex CIII2CIV. Nature. 2021;598(7880):364-367. doi:10.1038/s41586-021-03927-z
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2021 | Published | Journal Article | IST-REx-ID: 8993 |
Abas L, Kolb M, Stadlmann J, et al. Naphthylphthalamic acid associates with and inhibits PIN auxin transporters. Proceedings of the National Academy of Sciences of the United States of America. 2021;118(1). doi:10.1073/pnas.2020857118
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2020 | Published | Journal Article | IST-REx-ID: 8318 |
Gutierrez-Fernandez J, Kaszuba K, Minhas GS, et al. Key role of quinone in the mechanism of respiratory complex I. Nature Communications. 2020;11(1). doi:10.1038/s41467-020-17957-0
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2020 | Published | Journal Article | IST-REx-ID: 8579 |
Andrei A, Öztürk Y, Khalfaoui-Hassani B, et al. Cu homeostasis in bacteria: The ins and outs. Membranes. 2020;10(9). doi:10.3390/membranes10090242
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2020 | Published | Journal Article | IST-REx-ID: 8040
Gupta, Chitrak, Charge transfer and chemo-mechanical coupling in respiratory complex I. Journal of the American Chemical Society 142 (20). 2020
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2020 | Research Data Reference | IST-REx-ID: 9326
Gupta C, Khaniya U, Chan C, et al. Charge transfer and chemo-mechanical coupling in respiratory complex I. 2020. doi:10.1021/jacs.9b13450.s002
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2020 | Research Data Reference | IST-REx-ID: 9713
Gupta C, Khaniya U, Chan CK, et al. Supporting information. 2020. doi:10.1021/jacs.9b13450.s001
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2020 | Research Data Reference | IST-REx-ID: 9878
Gupta C, Khaniya U, Chan CK, et al. Movies. 2020. doi:10.1021/jacs.9b13450.s002
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2020 | Published | Journal Article | IST-REx-ID: 7788 |
Adjobo-Hermans, Merel J.W., NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4−/− mice and Leigh syndrome patients: A stabilizing role for NDUFAF2. Biochimica et Biophysica Acta - Bioenergetics 1861 (8). 2020
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2020 | Published | Journal Article | IST-REx-ID: 8581
Pinke, Gergely, Cryo-EM structure of the entire mammalian F-type ATP synthase. Nature Structural and Molecular Biology 27 (11). 2020
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2020 | Published | Journal Article | IST-REx-ID: 8737 |
Kampjut D, Sazanov LA. The coupling mechanism of mammalian respiratory complex I. Science. 2020;370(6516). doi:10.1126/science.abc4209
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2020 | Published | Thesis | IST-REx-ID: 8353 |
Steiner J. Biochemical and structural investigation of the Mrp antiporter, an ancestor of complex I. 2020. doi:10.15479/AT:ISTA:8353
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2020 | Published | Journal Article | IST-REx-ID: 8284 |
Steiner J, Sazanov LA. Structure and mechanism of the Mrp complex, an ancient cation/proton antiporter. eLife. 2020;9. doi:10.7554/eLife.59407
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2020 | Published | Thesis | IST-REx-ID: 8340 |
Kampjut D. Molecular mechanisms of mitochondrial redox-coupled proton pumping enzymes. 2020. doi:10.15479/AT:ISTA:8340
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2019 | Published | Journal Article | IST-REx-ID: 6352 |
Temnov AA, Rogov KA, Sklifas AN, et al. Protective properties of the cultured stem cell proteome studied in an animal model of acetaminophen-induced acute liver failure. Molecular Biology Reports. 2019. doi:10.1007/s11033-019-04765-z
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2019 | Published | Journal Article | IST-REx-ID: 6859
Zhou L, Sazanov LA. Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase. Science. 2019;365(6455). doi:10.1126/science.aaw9144
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2019 | Published | Journal Article | IST-REx-ID: 6919 |
Qi C, Minin GD, Vercellino I, Wutz A, Korkhov VM. Structural basis of sterol recognition by human hedgehog receptor PTCH1. Science Advances. 2019;5(9). doi:10.1126/sciadv.aaw6490
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2019 | Published | Journal Article | IST-REx-ID: 7395 |
Letts JA, Fiedorczuk K, Degliesposti G, Skehel M, Sazanov LA. Structures of respiratory supercomplex I+III2 reveal functional and conformational crosstalk. Molecular Cell. 2019;75(6):1131-1146.e6. doi:10.1016/j.molcel.2019.07.022
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2019 | Published | Journal Article | IST-REx-ID: 6848 |
Kampjut D, Sazanov LA. Structure and mechanism of mitochondrial proton-translocating transhydrogenase. Nature. 2019;573(7773):291–295. doi:10.1038/s41586-019-1519-2
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2018 | Published | Journal Article | IST-REx-ID: 152 |
Fiedorczuk K, Sazanov LA. Mammalian mitochondrial complex I structure and disease causing mutations. Trends in Cell Biology. 2018;28(10):835-867. doi:10.1016/j.tcb.2018.06.006
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2017 | Published | Book Chapter | IST-REx-ID: 444
Sazanov LA. Structure of respiratory complex I: “Minimal” bacterial and “de luxe” mammalian versions. In: Wikström M, ed. Mechanisms of Primary Energy Transduction in Biology . Mechanisms of Primary Energy Transduction in Biology . Royal Society of Chemistry; 2017:25-59. doi:10.1039/9781788010405-00025
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2017 | Published | Journal Article | IST-REx-ID: 515 |
Letts, James A, Clarifying the supercomplex: The higher-order organization of the mitochondrial electron transport chain. Nature Structural and Molecular Biology 24 (10). 2017
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2016 | Published | Journal Article | IST-REx-ID: 1186 |
Gutierrez-Fernandez J, Saleh M, Alcorlo M, et al. Modular architecture and unique teichoic acid recognition features of choline-binding protein L CbpL contributing to pneumococcal pathogenesis. Scientific Reports. 2016;6. doi:10.1038/srep38094
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2016 | Published | Journal Article | IST-REx-ID: 1276 |
Postila P, Kaszuba K, Kuleta P, et al. Atomistic determinants of co-enzyme Q reduction at the Qi-site of the cytochrome bc1 complex. Scientific Reports. 2016;6. doi:10.1038/srep33607
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2016 | Published | Journal Article | IST-REx-ID: 1288
Holt P, Efremov R, Nakamaru Ogiso E, Sazanov LA. Reversible FMN dissociation from Escherichia coli respiratory complex I. Biochimica et Biophysica Acta - Bioenergetics. 2016;1857(11):1777-1785. doi:10.1016/j.bbabio.2016.08.008
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2016 | Published | Journal Article | IST-REx-ID: 1521
Berrisford J, Baradaran R, Sazanov LA. Structure of bacterial respiratory complex I. Biochimica et Biophysica Acta - Bioenergetics. 2016;1857(7):892-901. doi:10.1016/j.bbabio.2016.01.012
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2016 | Published | Journal Article | IST-REx-ID: 1209 |
Letts JA, Degliesposti G, Fiedorczuk K, Skehel M, Sazanov LA. Purification of ovine respiratory complex i results in a highly active and stable preparation. Journal of Biological Chemistry. 2016;291(47):24657-24675. doi:10.1074/jbc.M116.735142
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2016 | Published | Journal Article | IST-REx-ID: 1226 |
Fiedorczuk K, Letts JA, Degliesposti G, Kaszuba K, Skehel M, Sazanov LA. Atomic structure of the entire mammalian mitochondrial complex i. Nature. 2016;538(7625):406-410. doi:10.1038/nature19794
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2016 | Published | Journal Article | IST-REx-ID: 1232
Letts JA, Fiedorczuk K, Sazanov LA. The architecture of respiratory supercomplexes. Nature. 2016;537(7622):644-648. doi:10.1038/nature19774
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2015 | Published | Journal Article | IST-REx-ID: 1683
Letts JA, Sazanov LA. Gaining mass: The structure of respiratory complex I-from bacterial towards mitochondrial versions. Current Opinion in Structural Biology. 2015;33(8):135-145. doi:10.1016/j.sbi.2015.08.008
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2015 | Published | Journal Article | IST-REx-ID: 1638
Sazanov LA. A giant molecular proton pump: structure and mechanism of respiratory complex I. Nature Reviews Molecular Cell Biology. 2015;16(6):375-388. doi:10.1038/nrm3997
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