Design Principles of Branching Morphogenesis
Project Period: 2020-07-01 – 2025-06-30
Funder:
European Research Council
Acronym
DEMOS
Principal Investigator
Department(s)
Grant Number
851288
Grant DOI
Funder
European Research Council
Funder Schema
H2020-ERC-StG
Funder Registry
21 Publications
2025 | Epub ahead of print | Journal Article | IST-REx-ID: 19373 | 
Mechanochemical bistability of intestinal organoids enables robust morphogenesis
S. Xue, Q. Yang, P. Liberali, E.B. Hannezo, Nature Physics (2025).
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S. Xue, Q. Yang, P. Liberali, E.B. Hannezo, Nature Physics (2025).
2025 | In Press | Journal Article | IST-REx-ID: 19703 |
Differential tissue deformability underlies fluid pressure-driven shape divergence of the avian embryonic brain and spinal cord
S.B.P. Mclaren, S. Xue, S. Ding, A.K. Winkel, O. Baldwin, S. Dwarakacherla, K. Franze, E.B. Hannezo, F. Xiong, Developmental Cell (n.d.).
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S.B.P. Mclaren, S. Xue, S. Ding, A.K. Winkel, O. Baldwin, S. Dwarakacherla, K. Franze, E.B. Hannezo, F. Xiong, Developmental Cell (n.d.).
2024 | Published | Journal Article | IST-REx-ID: 17269 |
Geometry-driven migration efficiency of autonomous epithelial cell clusters
E. Vercruysse, D. Brückner, M. Gómez-González, A. Remson, M. Luciano, Y. Kalukula, L. Rossetti, X. Trepat, E.B. Hannezo, S. Gabriele, Nature Physics 20 (2024) 1492–1500.
[Preprint]
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E. Vercruysse, D. Brückner, M. Gómez-González, A. Remson, M. Luciano, Y. Kalukula, L. Rossetti, X. Trepat, E.B. Hannezo, S. Gabriele, Nature Physics 20 (2024) 1492–1500.
2023 | Published | Journal Article | IST-REx-ID: 14426 |
Lineage tracing identifies heterogeneous hepatoblast contribution to cell lineages and postembryonic organ growth dynamics
I.A. Unterweger, J. Klepstad, E.B. Hannezo, P.R. Lundegaard, A. Trusina, E.A. Ober, PLoS Biology 21 (2023).
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I.A. Unterweger, J. Klepstad, E.B. Hannezo, P.R. Lundegaard, A. Trusina, E.A. Ober, PLoS Biology 21 (2023).
2023 | Published | Journal Article | IST-REx-ID: 14277 |
Interplay between mechanochemical patterning and glassy dynamics in cellular monolayers
D.R. Boocock, T. Hirashima, E.B. Hannezo, PRX Life 1 (2023).
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D.R. Boocock, T. Hirashima, E.B. Hannezo, PRX Life 1 (2023).
2023 | Published | Journal Article | IST-REx-ID: 12162 |
Modelling the dynamics of mammalian gut homeostasis
B. Corominas-Murtra, E.B. Hannezo, Seminars in Cell & Developmental Biology 150–151 (2023) 58–65.
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B. Corominas-Murtra, E.B. Hannezo, Seminars in Cell & Developmental Biology 150–151 (2023) 58–65.
2023 | Published | Journal Article | IST-REx-ID: 14378 |
Self-organized and directed branching results in optimal coverage in developing dermal lymphatic networks
M.C. Ucar, E.B. Hannezo, E. Tiilikainen, I. Liaqat, E. Jakobsson, H. Nurmi, K. Vaahtomeri, Nature Communications 14 (2023).
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M.C. Ucar, E.B. Hannezo, E. Tiilikainen, I. Liaqat, E. Jakobsson, H. Nurmi, K. Vaahtomeri, Nature Communications 14 (2023).
2023 | Published | Journal Article | IST-REx-ID: 14274 |
CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration
J.H. Alanko, M.C. Ucar, N. Canigova, J.A. Stopp, J. Schwarz, J. Merrin, E.B. Hannezo, M.K. Sixt, Science Immunology 8 (2023).
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J.H. Alanko, M.C. Ucar, N. Canigova, J.A. Stopp, J. Schwarz, J. Merrin, E.B. Hannezo, M.K. Sixt, Science Immunology 8 (2023).
2022 | Published | Journal Article | IST-REx-ID: 10825 |
Cell surface fluctuations regulate early embryonic lineage sorting
Yanagida, Ayaka, Cell surface fluctuations regulate early embryonic lineage sorting. Cell 185 (5). 2022
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Yanagida, Ayaka, Cell surface fluctuations regulate early embryonic lineage sorting. Cell 185 (5). 2022
2022 | Published | Journal Article | IST-REx-ID: 12274 |
Retrograde movements determine effective stem cell numbers in the intestine
Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, Bruens L, Webb AT, Laskaris D, Oost KC, Lafirenze SJA, Annusver K, Messal HA, Iqbal S, Flanagan DJ, Huels DJ, Rojas-Rodríguez F, Vizoso M, Kasper M, Sansom OJ, Snippert HJ, Liberali P, Simons BD, Katajisto P, Hannezo EB, van Rheenen J. 2022. Retrograde movements determine effective stem cell numbers in the intestine. Nature. 607(7919), 548–554.
[Submitted Version]
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Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, Bruens L, Webb AT, Laskaris D, Oost KC, Lafirenze SJA, Annusver K, Messal HA, Iqbal S, Flanagan DJ, Huels DJ, Rojas-Rodríguez F, Vizoso M, Kasper M, Sansom OJ, Snippert HJ, Liberali P, Simons BD, Katajisto P, Hannezo EB, van Rheenen J. 2022. Retrograde movements determine effective stem cell numbers in the intestine. Nature. 607(7919), 548–554.
2022 | Published | Journal Article | IST-REx-ID: 12217 |
Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids
S. Randriamanantsoa, A. Papargyriou, H.C. Maurer, K. Peschke, M. Schuster, G. Zecchin, K. Steiger, R. Öllinger, D. Saur, C. Scheel, R. Rad, E.B. Hannezo, M. Reichert, A.R. Bausch, Nature Communications 13 (2022).
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S. Randriamanantsoa, A. Papargyriou, H.C. Maurer, K. Peschke, M. Schuster, G. Zecchin, K. Steiger, R. Öllinger, D. Saur, C. Scheel, R. Rad, E.B. Hannezo, M. Reichert, A.R. Bausch, Nature Communications 13 (2022).
2022 | Published | Journal Article | IST-REx-ID: 12253 |
A self-generated Toddler gradient guides mesodermal cell migration
J. Stock, T. Kazmar, F. Schlumm, E.B. Hannezo, A. Pauli, Science Advances 8 (2022).
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J. Stock, T. Kazmar, F. Schlumm, E.B. Hannezo, A. Pauli, Science Advances 8 (2022).
2022 | Published | Journal Article | IST-REx-ID: 12209 |
Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming
D.C. Nunes Pinheiro, R. Kardos, E.B. Hannezo, C.-P.J. Heisenberg, Nature Physics 18 (2022) 1482–1493.
[Published Version]
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D.C. Nunes Pinheiro, R. Kardos, E.B. Hannezo, C.-P.J. Heisenberg, Nature Physics 18 (2022) 1482–1493.
2021 | Published | Journal Article | IST-REx-ID: 10365 |
Cell monolayers sense curvature by exploiting active mechanics and nuclear mechanoadaptation
M. Luciano, S. Xue, W.H. De Vos, L. Redondo-Morata, M. Surin, F. Lafont, E.B. Hannezo, S. Gabriele, Nature Physics 17 (2021) 1382–1390.
[Submitted Version]
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M. Luciano, S. Xue, W.H. De Vos, L. Redondo-Morata, M. Surin, F. Lafont, E.B. Hannezo, S. Gabriele, Nature Physics 17 (2021) 1382–1390.
2021 | Published | Journal Article | IST-REx-ID: 9629 |
Cell fate coordinates mechano-osmotic forces in intestinal crypt formation
Q. Yang, S. Xue, C.J. Chan, M. Rempfler, D. Vischi, F. Maurer-Gutierrez, T. Hiiragi, E.B. Hannezo, P. Liberali, Nature Cell Biology 23 (2021) 733–744.
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Q. Yang, S. Xue, C.J. Chan, M. Rempfler, D. Vischi, F. Maurer-Gutierrez, T. Hiiragi, E.B. Hannezo, P. Liberali, Nature Cell Biology 23 (2021) 733–744.
2021 | Published | Journal Article | IST-REx-ID: 9244 |
DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for alagille syndrome
S. Hankeova, J. Salplachta, T. Zikmund, M. Kavkova, N. Van Hul, A. Brinek, V. Smekalova, J. Laznovsky, F. Dawit, J. Jaros, V. Bryja, U. Lendahl, E. Ellis, A. Nemeth, B. Fischler, E.B. Hannezo, J. Kaiser, E.R. Andersson, ELife 10 (2021).
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S. Hankeova, J. Salplachta, T. Zikmund, M. Kavkova, N. Van Hul, A. Brinek, V. Smekalova, J. Laznovsky, F. Dawit, J. Jaros, V. Bryja, U. Lendahl, E. Ellis, A. Nemeth, B. Fischler, E.B. Hannezo, J. Kaiser, E.R. Andersson, ELife 10 (2021).
2021 | Published | Journal Article | IST-REx-ID: 10402 |
Theory of branching morphogenesis by local interactions and global guidance
M.C. Ucar, D. Kamenev, K. Sunadome, D.C. Fachet, F. Lallemend, I. Adameyko, S. Hadjab, E.B. Hannezo, Nature Communications 12 (2021).
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M.C. Ucar, D. Kamenev, K. Sunadome, D.C. Fachet, F. Lallemend, I. Adameyko, S. Hadjab, E.B. Hannezo, Nature Communications 12 (2021).
2021 | Published | Journal Article | IST-REx-ID: 9316 |
Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions
Petridou, Nicoletta, Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. Cell 184 (7). 2021
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Petridou, Nicoletta, Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. Cell 184 (7). 2021
2021 | Published | Journal Article | IST-REx-ID: 8602 |
Theory of mechanochemical patterning and optimal migration in cell monolayers
Boocock, Daniel R, Theory of mechanochemical patterning and optimal migration in cell monolayers. Nature Physics 17. 2021
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Boocock, Daniel R, Theory of mechanochemical patterning and optimal migration in cell monolayers. Nature Physics 17. 2021
2021 | Published | Journal Article | IST-REx-ID: 9349 |
Roadmap for the multiscale coupling of biochemical and mechanical signals during development
Lenne PF, Munro E, Heemskerk I, Warmflash A, Bocanegra L, Kishi K, Kicheva A, Long Y, Fruleux A, Boudaoud A, Saunders TE, Caldarelli P, Michaut A, Gros J, Maroudas-Sacks Y, Keren K, Hannezo EB, Gartner ZJ, Stormo B, Gladfelter A, Rodrigues A, Shyer A, Minc N, Maître JL, Di Talia S, Khamaisi B, Sprinzak D, Tlili S. 2021. Roadmap for the multiscale coupling of biochemical and mechanical signals during development. Physical biology. 18(4), 041501.
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Lenne PF, Munro E, Heemskerk I, Warmflash A, Bocanegra L, Kishi K, Kicheva A, Long Y, Fruleux A, Boudaoud A, Saunders TE, Caldarelli P, Michaut A, Gros J, Maroudas-Sacks Y, Keren K, Hannezo EB, Gartner ZJ, Stormo B, Gladfelter A, Rodrigues A, Shyer A, Minc N, Maître JL, Di Talia S, Khamaisi B, Sprinzak D, Tlili S. 2021. Roadmap for the multiscale coupling of biochemical and mechanical signals during development. Physical biology. 18(4), 041501.