Revealing the mechanisms underlying drug interactions

Antimicrobial interactions: Mechanisms and implications for drug discovery and resistance evolution
M.T. Bollenbach, Current Opinion in Microbiology 27 (2015) 1–9.

Systematic discovery of drug interaction mechanisms
G. Chevereau, M.T. Bollenbach, Molecular Systems Biology 11 (2015).

Mapping the mouse Allelome reveals tissue specific regulation of allelic expression
D. Andergassen, C. Dotter, D. Wenzel, V. Sigl, P. Bammer, M. Muckenhuber, D. Mayer, T. Kulinski, H. Theussl, J. Penninger, C. Bock, D. Barlow, F. Pauler, Q. Hudson, ELife 6 (2017).

Intron-mediated induction of phenotypic heterogeneity
M. Lukacisin, A. Espinosa-Cantú, M.T. Bollenbach, Nature 605 (2022) 113–118.

Uncovering Key Metabolic Determinants of the Drug Interactions Between Trimethoprim and Erythromycin in Escherichia coli
Q. Qi, S.A. Angermayr, M.T. Bollenbach, Frontiers in Microbiology 12 (2021).

Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
M. Lukacisinova, B. Fernando, M.T. Bollenbach, Nature Communications 11 (2020).

Temporal order and precision of complex stress responses in individual bacteria
K. Mitosch, G. Rieckh, M.T. Bollenbach, Molecular Systems Biology 15 (2019).

Emergent gene expression responses to drug combinations predict higher-order drug interactions
M. Lukacisin, M.T. Bollenbach, Cell Systems 9 (2019) 423-433.e1-e3.

Noisy response to antibiotic stress predicts subsequent single cell survival in an acidic environment
K. Mitosch, G. Rieckh, M.T. Bollenbach, Cell Systems 4 (2017) 393–403.

Interaction networks, ecological stability, and collective antibiotic tolerance in polymicrobial infections
M. de Vos, M.P. Zagórski, A. Mcnally, M.T. Bollenbach, PNAS 114 (2017) 10666–10671.

Minimal biophysical model of combined antibiotic action
B. Kavcic, G. Tkačik, M.T. Bollenbach, PLOS Computational Biology 17 (2021).

Mechanisms of drug interactions between translation-inhibiting antibiotics
B. Kavcic, G. Tkačik, M.T. Bollenbach, Nature Communications 11 (2020).

A minimal biophysical model of combined antibiotic action
B. Kavcic, G. Tkačik, M.T. Bollenbach, BioRxiv (2020).

The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection
F. Ebner, V. Sedlyarov, S. Tasciyan, M. Ivin, F. Kratochvill, N. Gratz, L. Kenner, A. Villunger, M.K. Sixt, P. Kovarik, The Journal of Clinical Investigation 127 (2017) 2051–2065.

Quantifying the determinants of evolutionary dynamics leading to drug resistance
G. Chevereau, M. Lukacisinova, T. Batur, A. Guvenek, D. Ayhan, E. Toprak, M.T. Bollenbach, PLoS Biology 13 (2015).

Toward a quantitative understanding of antibiotic resistance evolution
M. Lukacisinova, M.T. Bollenbach, Current Opinion in Biotechnology 46 (2017) 90–97.