POM121 and Sun1 play a role in early steps of interphase NPC assembly
Talamas JA, Hetzer M. 2011. POM121 and Sun1 play a role in early steps of interphase NPC assembly. Journal of Cell Biology. 194(1), 27–37.
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https://doi.org/10.1083/jcb.201012154
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Journal Article
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Author
Talamas, Jessica A.;
Hetzer, MartinISTA
Corresponding author has ISTA affiliation
Abstract
Nuclear pore complexes (NPCs) assemble at the end of mitosis during nuclear envelope (NE) reformation and into an intact NE as cells progress through interphase. Although recent studies have shown that NPC formation occurs by two different molecular mechanisms at two distinct cell cycle stages, little is known about the molecular players that mediate the fusion of the outer and inner nuclear membranes to form pores. In this paper, we provide evidence that the transmembrane nucleoporin (Nup), POM121, but not the Nup107–160 complex, is present at new pore assembly sites at a time that coincides with inner nuclear membrane (INM) and outer nuclear membrane (ONM) fusion. Overexpression of POM121 resulted in juxtaposition of the INM and ONM. Additionally, Sun1, an INM protein that is known to interact with the cytoskeleton, was specifically required for interphase assembly and localized with POM121 at forming pores. We propose a model in which POM121 and Sun1 interact transiently to promote early steps of interphase NPC assembly.
Keywords
Publishing Year
Date Published
2011-07-04
Journal Title
Journal of Cell Biology
Publisher
Rockefeller University Press
Volume
194
Issue
1
Page
27-37
ISSN
eISSN
IST-REx-ID
Cite this
Talamas JA, Hetzer M. POM121 and Sun1 play a role in early steps of interphase NPC assembly. Journal of Cell Biology. 2011;194(1):27-37. doi:10.1083/jcb.201012154
Talamas, J. A., & Hetzer, M. (2011). POM121 and Sun1 play a role in early steps of interphase NPC assembly. Journal of Cell Biology. Rockefeller University Press. https://doi.org/10.1083/jcb.201012154
Talamas, Jessica A., and Martin Hetzer. “POM121 and Sun1 Play a Role in Early Steps of Interphase NPC Assembly.” Journal of Cell Biology. Rockefeller University Press, 2011. https://doi.org/10.1083/jcb.201012154.
J. A. Talamas and M. Hetzer, “POM121 and Sun1 play a role in early steps of interphase NPC assembly,” Journal of Cell Biology, vol. 194, no. 1. Rockefeller University Press, pp. 27–37, 2011.
Talamas JA, Hetzer M. 2011. POM121 and Sun1 play a role in early steps of interphase NPC assembly. Journal of Cell Biology. 194(1), 27–37.
Talamas, Jessica A., and Martin Hetzer. “POM121 and Sun1 Play a Role in Early Steps of Interphase NPC Assembly.” Journal of Cell Biology, vol. 194, no. 1, Rockefeller University Press, 2011, pp. 27–37, doi:10.1083/jcb.201012154.
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