Phenotype control of partially specified boolean networks
Beneš N, Brim L, Pastva S, Šafránek D, Šmijáková E. 2023. Phenotype control of partially specified boolean networks. 21st International Conference on Computational Methods in Systems Biology. CMSB: Computational Methods in Systems Biology, LNBI, vol. 14137, 18–35.
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Author
Beneš, Nikola;
Brim, Luboš;
Pastva, SamuelISTA 
;
Šafránek, David;
Šmijáková, Eva
;
Šafránek, David;
Šmijáková, EvaDepartment
Series Title
LNBI
Abstract
Partially specified Boolean networks (PSBNs) represent a promising framework for the qualitative modelling of biological systems in which the logic of interactions is not completely known. Phenotype control aims to stabilise the network in states exhibiting specific traits.
In this paper, we define the phenotype control problem in the context of asynchronous PSBNs and propose a novel semi-symbolic algorithm for solving this problem with permanent variable perturbations.
Publishing Year
Date Published
2023-09-09
Proceedings Title
21st International Conference on Computational Methods in Systems Biology
Acknowledgement
This work was supported by the Czech Foundation grant No. GA22-10845S, Grant Agency of Masaryk University grant No. MUNI/G/1771/2020, and the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 101034413.
Volume
14137
Page
18-35
Conference
CMSB: Computational Methods in Systems Biology
Conference Location
Luxembourg City, Luxembourg
Conference Date
2023-09-13 – 2023-09-15
ISBN
ISSN
eISSN
IST-REx-ID
Cite this
Beneš N, Brim L, Pastva S, Šafránek D, Šmijáková E. Phenotype control of partially specified boolean networks. In: 21st International Conference on Computational Methods in Systems Biology. Vol 14137. Springer Nature; 2023:18-35. doi:10.1007/978-3-031-42697-1_2
Beneš, N., Brim, L., Pastva, S., Šafránek, D., & Šmijáková, E. (2023). Phenotype control of partially specified boolean networks. In 21st International Conference on Computational Methods in Systems Biology (Vol. 14137, pp. 18–35). Luxembourg City, Luxembourg: Springer Nature. https://doi.org/10.1007/978-3-031-42697-1_2
Beneš, Nikola, Luboš Brim, Samuel Pastva, David Šafránek, and Eva Šmijáková. “Phenotype Control of Partially Specified Boolean Networks.” In 21st International Conference on Computational Methods in Systems Biology, 14137:18–35. Springer Nature, 2023. https://doi.org/10.1007/978-3-031-42697-1_2.
N. Beneš, L. Brim, S. Pastva, D. Šafránek, and E. Šmijáková, “Phenotype control of partially specified boolean networks,” in 21st International Conference on Computational Methods in Systems Biology, Luxembourg City, Luxembourg, 2023, vol. 14137, pp. 18–35.
Beneš N, Brim L, Pastva S, Šafránek D, Šmijáková E. 2023. Phenotype control of partially specified boolean networks. 21st International Conference on Computational Methods in Systems Biology. CMSB: Computational Methods in Systems Biology, LNBI, vol. 14137, 18–35.
Beneš, Nikola, et al. “Phenotype Control of Partially Specified Boolean Networks.” 21st International Conference on Computational Methods in Systems Biology, vol. 14137, Springer Nature, 2023, pp. 18–35, doi:10.1007/978-3-031-42697-1_2.
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