Tissue active matter: Integrating mechanics and signaling into dynamical models
Brückner D, Hannezo EB. 2024. Tissue active matter: Integrating mechanics and signaling into dynamical models. Cold Spring Harbor Perspectives in Biology., a041653.
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| Epub ahead of print
| English
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Abstract
The importance of physical forces in the morphogenesis, homeostatic function, and pathological dysfunction of multicellular tissues is being increasingly characterized, both theoretically and experimentally. Analogies between biological systems and inert materials such as foams, gels, and liquid crystals have provided striking insights into the core design principles underlying multicellular organization. However, these connections can seem surprising given that a key feature of multicellular systems is their ability to constantly consume energy, providing an active origin for the forces that they produce. Key emerging questions are, therefore, to understand whether and how this activity grants tissues novel properties that do not have counterparts in classical materials, as well as their consequences for biological function. Here, we review recent discoveries at the intersection of active matter and tissue biology, with an emphasis on how modeling and experiments can be combined to understand the dynamics of multicellular systems. These approaches suggest that a number of key biological tissue-scale phenomena, such as morphogenetic shape changes, collective migration, or fate decisions, share unifying design principles that can be described by physical models of tissue active matter.
Publishing Year
Date Published
2024-07-01
Journal Title
Cold Spring Harbor Perspectives in Biology
Publisher
Cold Spring Harbor Laboratory
Article Number
a041653
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IST-REx-ID
Cite this
Brückner D, Hannezo EB. Tissue active matter: Integrating mechanics and signaling into dynamical models. Cold Spring Harbor Perspectives in Biology. 2024. doi:10.1101/cshperspect.a041653
Brückner, D., & Hannezo, E. B. (2024). Tissue active matter: Integrating mechanics and signaling into dynamical models. Cold Spring Harbor Perspectives in Biology. Cold Spring Harbor Laboratory. https://doi.org/10.1101/cshperspect.a041653
Brückner, David, and Edouard B Hannezo. “Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models.” Cold Spring Harbor Perspectives in Biology. Cold Spring Harbor Laboratory, 2024. https://doi.org/10.1101/cshperspect.a041653.
D. Brückner and E. B. Hannezo, “Tissue active matter: Integrating mechanics and signaling into dynamical models,” Cold Spring Harbor Perspectives in Biology. Cold Spring Harbor Laboratory, 2024.
Brückner D, Hannezo EB. 2024. Tissue active matter: Integrating mechanics and signaling into dynamical models. Cold Spring Harbor Perspectives in Biology., a041653.
Brückner, David, and Edouard B. Hannezo. “Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models.” Cold Spring Harbor Perspectives in Biology, a041653, Cold Spring Harbor Laboratory, 2024, doi:10.1101/cshperspect.a041653.
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