Acute and circadian feedforward regulation of agouti-related peptide hunger neurons

Douglass AM, Kucukdereli H, Madara JC, Wang D, Wu C, Lowenstein ED, Tao J, Lowell BB. 2024. Acute and circadian feedforward regulation of agouti-related peptide hunger neurons. Cell Metabolism. 37(3), 708–722.e5.

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Journal Article | Published | English

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Author
Douglass, Amelia M.ISTA ; Kucukdereli, Hakan; Madara, Joseph C.; Wang, Daqing; Wu, Chen; Lowenstein, Elijah D.; Tao, Jenkang; Lowell, Bradford B.
Abstract
When food is freely available, eating occurs without energy deficit. While agouti-related peptide (AgRP) neurons are likely involved, their activation is thought to require negative energy balance. To investigate this, we implemented long-term, continuous in vivo fiber-photometry recordings in mice. We discovered new forms of AgRP neuron regulation, including fast pre-ingestive decreases in activity and unexpectedly rapid activation by fasting. Furthermore, AgRP neuron activity has a circadian rhythm that peaks concurrent with the daily feeding onset. Importantly, this rhythm persists when nutrition is provided via constant-rate gastric infusions. Hence, it is not secondary to a circadian feeding rhythm. The AgRP neuron rhythm is driven by the circadian clock, the suprachiasmatic nucleus (SCN), as SCN ablation abolishes the circadian rhythm in AgRP neuron activity and feeding. The SCN activates AgRP neurons via excitatory afferents from thyrotrophin-releasing hormone-expressing neurons in the dorsomedial hypothalamus (DMHTrh neurons) to drive daily feeding rhythms.
Publishing Year
Date Published
2024-03-04
Journal Title
Cell Metabolism
Publisher
Elsevier
Volume
37
Issue
3
Page
708-722.e5
ISSN
IST-REx-ID

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Douglass AM, Kucukdereli H, Madara JC, et al. Acute and circadian feedforward regulation of agouti-related peptide hunger neurons. Cell Metabolism. 2024;37(3):708-722.e5. doi:10.1016/j.cmet.2024.11.009
Douglass, A. M., Kucukdereli, H., Madara, J. C., Wang, D., Wu, C., Lowenstein, E. D., … Lowell, B. B. (2024). Acute and circadian feedforward regulation of agouti-related peptide hunger neurons. Cell Metabolism. Elsevier. https://doi.org/10.1016/j.cmet.2024.11.009
Douglass, Amelia M., Hakan Kucukdereli, Joseph C. Madara, Daqing Wang, Chen Wu, Elijah D. Lowenstein, Jenkang Tao, and Bradford B. Lowell. “Acute and Circadian Feedforward Regulation of Agouti-Related Peptide Hunger Neurons.” Cell Metabolism. Elsevier, 2024. https://doi.org/10.1016/j.cmet.2024.11.009.
A. M. Douglass et al., “Acute and circadian feedforward regulation of agouti-related peptide hunger neurons,” Cell Metabolism, vol. 37, no. 3. Elsevier, p. 708–722.e5, 2024.
Douglass AM, Kucukdereli H, Madara JC, Wang D, Wu C, Lowenstein ED, Tao J, Lowell BB. 2024. Acute and circadian feedforward regulation of agouti-related peptide hunger neurons. Cell Metabolism. 37(3), 708–722.e5.
Douglass, Amelia M., et al. “Acute and Circadian Feedforward Regulation of Agouti-Related Peptide Hunger Neurons.” Cell Metabolism, vol. 37, no. 3, Elsevier, 2024, p. 708–722.e5, doi:10.1016/j.cmet.2024.11.009.

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