DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation

Morcom L, Gobius I, Marsh AP, Suárez R, Lim JW, Bridges C, Ye Y, Fenlon LR, Zagar Y, Douglass AM, Donahoo A-LS, Fothergill T, Shaikh S, Kozulin P, Edwards TJ, Cooper HM, Sherr EH, Chédotal A, Leventer RJ, Lockhart PJ, Richards LJ. 2021. DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation. eLife. 10, 61769.

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Author
Morcom, Laura; Gobius, Ilan; Marsh, Ashley PL; Suárez, Rodrigo; Lim, Jonathan WC; Bridges, Caitlin; Ye, Yunan; Fenlon, Laura R; Zagar, Yvrick; Douglass, Amelia M.ISTA ; Donahoo, Amber-Lee S; Fothergill, Thomas
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Abstract
The forebrain hemispheres are predominantly separated during embryogenesis by the interhemispheric fissure (IHF). Radial astroglia remodel the IHF to form a continuous substrate between the hemispheres for midline crossing of the corpus callosum (CC) and hippocampal commissure (HC). Deleted in colorectal carcinoma (DCC) and netrin 1 (NTN1) are molecules that have an evolutionarily conserved function in commissural axon guidance. The CC and HC are absent in <jats:italic>Dcc</jats:italic> and <jats:italic>Ntn1</jats:italic> knockout mice, while other commissures are only partially affected, suggesting an additional aetiology in forebrain commissure formation. Here, we find that these molecules play a critical role in regulating astroglial development and IHF remodelling during CC and HC formation. Human subjects with <jats:italic>DCC</jats:italic> mutations display disrupted IHF remodelling associated with CC and HC malformations. Thus, axon guidance molecules such as DCC and NTN1 first regulate the formation of a midline substrate for dorsal commissures prior to their role in regulating axonal growth and guidance across it.
Publishing Year
Date Published
2021-04-19
Journal Title
eLife
Publisher
eLife Sciences Publications
Volume
10
Article Number
61769
eISSN
IST-REx-ID

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Morcom L, Gobius I, Marsh AP, et al. DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation. eLife. 2021;10. doi:10.7554/elife.61769
Morcom, L., Gobius, I., Marsh, A. P., Suárez, R., Lim, J. W., Bridges, C., … Richards, L. J. (2021). DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation. ELife. eLife Sciences Publications. https://doi.org/10.7554/elife.61769
Morcom, Laura, Ilan Gobius, Ashley PL Marsh, Rodrigo Suárez, Jonathan WC Lim, Caitlin Bridges, Yunan Ye, et al. “DCC Regulates Astroglial Development Essential for Telencephalic Morphogenesis and Corpus Callosum Formation.” ELife. eLife Sciences Publications, 2021. https://doi.org/10.7554/elife.61769.
L. Morcom et al., “DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation,” eLife, vol. 10. eLife Sciences Publications, 2021.
Morcom L, Gobius I, Marsh AP, Suárez R, Lim JW, Bridges C, Ye Y, Fenlon LR, Zagar Y, Douglass AM, Donahoo A-LS, Fothergill T, Shaikh S, Kozulin P, Edwards TJ, Cooper HM, Sherr EH, Chédotal A, Leventer RJ, Lockhart PJ, Richards LJ. 2021. DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation. eLife. 10, 61769.
Morcom, Laura, et al. “DCC Regulates Astroglial Development Essential for Telencephalic Morphogenesis and Corpus Callosum Formation.” ELife, vol. 10, 61769, eLife Sciences Publications, 2021, doi:10.7554/elife.61769.
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