Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism
Efanov A, Koshkin A, Sazanov LA, Borodulina OI, Varfolomeev S, Zaǐtsev S. 1994. Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism. FEBS Letters. 355(2), 114–116.
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Author
Efanov, Alexander;
Koshkin, Aleksei;
Sazanov, Leonid AISTA 
;
Borodulina, O I;
Varfolomeev, Sergei;
Zaǐtsev, Sergei
;
Borodulina, O I;
Varfolomeev, Sergei;
Zaǐtsev, SergeiAbstract
The respiratory burst induced by phorbol myristate acetate in mouse macrophages was inhibited by ultra-low doses (10-15 -10-13 M) of an opioid peptide [d-Ala2] methionine enkephalinamide. The effect disappeared at concentrations above and below this range. The inhibition approached 50% and was statistically significant (P < 0.001). Increasing the time of the opioid incubation with cells brought about a shift in the maximal effect to lower concentrations of the opioid (from 10-13 to 5 · 10-15 M) and led to a decrease in the value of the effect, fully in accord with the previously proposed adaptation mechanism of the action of ultra-low doses.
Publishing Year
Date Published
1994-11-28
Journal Title
FEBS Letters
Publisher
Elsevier
Volume
355
Issue
2
Page
114 - 116
ISSN
IST-REx-ID
Cite this
Efanov A, Koshkin A, Sazanov LA, Borodulina OI, Varfolomeev S, Zaǐtsev S. Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism. FEBS Letters. 1994;355(2):114-116. doi:10.1016/0014-5793(94)01109-5
Efanov, A., Koshkin, A., Sazanov, L. A., Borodulina, O. I., Varfolomeev, S., & Zaǐtsev, S. (1994). Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism. FEBS Letters. Elsevier. https://doi.org/10.1016/0014-5793(94)01109-5
Efanov, Alexander, Aleksei Koshkin, Leonid A Sazanov, O I Borodulina, Sergei Varfolomeev, and Sergei Zaǐtsev. “Inhibition of the Respiratory Burst in Mouse Macrophages by Ultra-Low Doses of an Opioid Peptide Is Consistent with a Possible Adaptation Mechanism.” FEBS Letters. Elsevier, 1994. https://doi.org/10.1016/0014-5793(94)01109-5.
A. Efanov, A. Koshkin, L. A. Sazanov, O. I. Borodulina, S. Varfolomeev, and S. Zaǐtsev, “Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism,” FEBS Letters, vol. 355, no. 2. Elsevier, pp. 114–116, 1994.
Efanov A, Koshkin A, Sazanov LA, Borodulina OI, Varfolomeev S, Zaǐtsev S. 1994. Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism. FEBS Letters. 355(2), 114–116.
Efanov, Alexander, et al. “Inhibition of the Respiratory Burst in Mouse Macrophages by Ultra-Low Doses of an Opioid Peptide Is Consistent with a Possible Adaptation Mechanism.” FEBS Letters, vol. 355, no. 2, Elsevier, 1994, pp. 114–16, doi:10.1016/0014-5793(94)01109-5.
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