Multivalent interactions between an aromatic helical foldamer and a DNA G‐quadruplex in the solid state
Mandal PK, Baptiste B, Langlois d’Estaintot B, Kauffmann B, Huc I. 2016. Multivalent interactions between an aromatic helical foldamer and a DNA G‐quadruplex in the solid state. ChemBioChem. 17(20), 1911–1914.
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Journal Article
| Published
| English
Author
Mandal, Pradeep KISTA 
;
Baptiste, Benoît;
Langlois d'Estaintot, Béatrice;
Kauffmann, Brice;
Huc, Ivan
;
Baptiste, Benoît;
Langlois d'Estaintot, Béatrice;
Kauffmann, Brice;
Huc, IvanAbstract
Quinoline‐based oligoamide foldamers have been identified as a potent class of ligands for G‐quadruplex DNA. Their helical structure is thought to target G‐quadruplex loops or grooves and not G‐tetrads. We report a co‐crystal structure of the antiparallel hairpin dimeric DNA G‐quadruplex (G4T4G4)2 with tetramer 1a helically folded oligo‐quinolinecarboxamide bearing cationic side chains—that is consistent with this hypothesis. Multivalent foldamer-DNA interactions that modify the packing of (G4T4G4)2 in the solid state are observed.
Publishing Year
Date Published
2016-10-17
Journal Title
ChemBioChem
Publisher
Wiley
Volume
17
Issue
20
Page
1911-1914
ISSN
eISSN
IST-REx-ID
Cite this
Mandal PK, Baptiste B, Langlois d’Estaintot B, Kauffmann B, Huc I. Multivalent interactions between an aromatic helical foldamer and a DNA G‐quadruplex in the solid state. ChemBioChem. 2016;17(20):1911-1914. doi:10.1002/cbic.201600281
Mandal, P. K., Baptiste, B., Langlois d’Estaintot, B., Kauffmann, B., & Huc, I. (2016). Multivalent interactions between an aromatic helical foldamer and a DNA G‐quadruplex in the solid state. ChemBioChem. Wiley. https://doi.org/10.1002/cbic.201600281
Mandal, Pradeep K, Benoît Baptiste, Béatrice Langlois d’Estaintot, Brice Kauffmann, and Ivan Huc. “Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G‐quadruplex in the Solid State.” ChemBioChem. Wiley, 2016. https://doi.org/10.1002/cbic.201600281.
P. K. Mandal, B. Baptiste, B. Langlois d’Estaintot, B. Kauffmann, and I. Huc, “Multivalent interactions between an aromatic helical foldamer and a DNA G‐quadruplex in the solid state,” ChemBioChem, vol. 17, no. 20. Wiley, pp. 1911–1914, 2016.
Mandal PK, Baptiste B, Langlois d’Estaintot B, Kauffmann B, Huc I. 2016. Multivalent interactions between an aromatic helical foldamer and a DNA G‐quadruplex in the solid state. ChemBioChem. 17(20), 1911–1914.
Mandal, Pradeep K., et al. “Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G‐quadruplex in the Solid State.” ChemBioChem, vol. 17, no. 20, Wiley, 2016, pp. 1911–14, doi:10.1002/cbic.201600281.
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