Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons
Leingärtner A, Heisenberg C-PJ, Kolbeck R, Thoenen H, Lindholm D. 1994. Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons. Journal of Biological Chemistry. 269(2), 828–830.
Journal Article
| Published
| English
Scopus indexed
Author
Leingärtner, Axel;
Heisenberg, Carl-Philipp ISTA 
;
Kolbeck, Roland;
Thoenen, Hans;
Lindholm, Dan
;
Kolbeck, Roland;
Thoenen, Hans;
Lindholm, DanAbstract
Neurotrophin-3 (NT-3) is a member of the neurotrophin gene family and is highly expressed in the developing rat cerebellum. Here we show that brain-derived neurotrophic factor (BDNF) increased by approximately 10-fold the NT-3 mRNA levels in cultured cerebellar granule neurons isolated from postnatal rats, whereas nerve growth factor (NGF) and NT-3 itself had no effect. The effect of BDNF was additive to that of triiodothyronine (T3), which also increased NT-3 mRNA in these neurons. The drug K252a inhibited the BDNF-mediated stimulation of NT-3 expression, suggesting an involvement of trkB receptors. Nuclear run-on experiments showed that BDNF enhanced NT-3 transcription, whereas the stability of NT-3 mRNA remained unchanged. The data presented are the first demonstration that one neurotrophin regulates the expression of another and provide evidence that NT-3 production in granule neurons is regulated by both BDNF and T3.
Publishing Year
Date Published
1994-01-14
Journal Title
Journal of Biological Chemistry
Publisher
American Society for Biochemistry and Molecular Biology
Acknowledgement
We thank Dorothea Stratmann and Karin Angermayer for skillful technical assistance.
Volume
269
Issue
2
Page
828 - 830
ISSN
eISSN
IST-REx-ID
Cite this
Leingärtner A, Heisenberg C-PJ, Kolbeck R, Thoenen H, Lindholm D. Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons. Journal of Biological Chemistry. 1994;269(2):828-830. doi:10.1016/s0021-9258(17)42186-7
Leingärtner, A., Heisenberg, C.-P. J., Kolbeck, R., Thoenen, H., & Lindholm, D. (1994). Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1016/s0021-9258(17)42186-7
Leingärtner, Axel, Carl-Philipp J Heisenberg, Roland Kolbeck, Hans Thoenen, and Dan Lindholm. “Brain-Derived Neurotrophic Factor Increases Neurotrophin-3 Expression in Cerebellar Granule Neurons.” Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 1994. https://doi.org/10.1016/s0021-9258(17)42186-7.
A. Leingärtner, C.-P. J. Heisenberg, R. Kolbeck, H. Thoenen, and D. Lindholm, “Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons,” Journal of Biological Chemistry, vol. 269, no. 2. American Society for Biochemistry and Molecular Biology, pp. 828–830, 1994.
Leingärtner A, Heisenberg C-PJ, Kolbeck R, Thoenen H, Lindholm D. 1994. Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons. Journal of Biological Chemistry. 269(2), 828–830.
Leingärtner, Axel, et al. “Brain-Derived Neurotrophic Factor Increases Neurotrophin-3 Expression in Cerebellar Granule Neurons.” Journal of Biological Chemistry, vol. 269, no. 2, American Society for Biochemistry and Molecular Biology, 1994, pp. 828–30, doi:10.1016/s0021-9258(17)42186-7.
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