Selection for functional uniformity of tuf duplicates in γ-proteobacteria
Kondrashov F, Gurbich T, Vlasov P. 2007. Selection for functional uniformity of tuf duplicates in γ-proteobacteria. Trends in Genetics. 23(5), 215–218.
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Journal Article
| Published
Author
Kondrashov, FyodorISTA 
;
Gurbich, Tatiana A;
Vlasov, Peter K
;
Gurbich, Tatiana A;
Vlasov, Peter KAbstract
Having an extra copy of a gene is thought to provide some functional redundancy, which results in a higher rate of evolution in duplicated genes. In this article, we estimate the impact of gene duplication on the selection of tuf paralogs, and we find that in the absence of gene conversion, tuf paralogs have evolved significantly slower than when gene conversion has been a factor in their evolution. Thus, tuf gene copies evolve under a selective pressure that ensures their functional uniformity, and gene conversion reduces selection against amino acid substitutions that affect the function of the encoded protein, EF-Tu.
Publishing Year
Date Published
2007-05-01
Journal Title
Trends in Genetics
Acknowledgement
We thank Peter Andolfatto, Doris Bachtrog, Robert Cutler, Hideki Innan, Eugene Koonin, Alexey Kondrashov and Martin Lercher for comments on the manuscript and for discussions on the interplay between gene conversion and selection. This work was supported by a National Science Foundation Graduate Research Fellowship (F.A.K.) and a Molecular and Cellular Biology RAS (Program No 10) grant (P.K.V.).
Volume
23
Issue
5
Page
215 - 218
IST-REx-ID
Cite this
Kondrashov F, Gurbich T, Vlasov P. Selection for functional uniformity of tuf duplicates in γ-proteobacteria. Trends in Genetics. 2007;23(5):215-218. doi:10.1016/j.tig.2007.03.002
Kondrashov, F., Gurbich, T., & Vlasov, P. (2007). Selection for functional uniformity of tuf duplicates in γ-proteobacteria. Trends in Genetics. Elsevier. https://doi.org/10.1016/j.tig.2007.03.002
Kondrashov, Fyodor, Tatiana Gurbich, and Peter Vlasov. “Selection for Functional Uniformity of Tuf Duplicates in γ-Proteobacteria.” Trends in Genetics. Elsevier, 2007. https://doi.org/10.1016/j.tig.2007.03.002.
F. Kondrashov, T. Gurbich, and P. Vlasov, “Selection for functional uniformity of tuf duplicates in γ-proteobacteria,” Trends in Genetics, vol. 23, no. 5. Elsevier, pp. 215–218, 2007.
Kondrashov F, Gurbich T, Vlasov P. 2007. Selection for functional uniformity of tuf duplicates in γ-proteobacteria. Trends in Genetics. 23(5), 215–218.
Kondrashov, Fyodor, et al. “Selection for Functional Uniformity of Tuf Duplicates in γ-Proteobacteria.” Trends in Genetics, vol. 23, no. 5, Elsevier, 2007, pp. 215–18, doi:10.1016/j.tig.2007.03.002.
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