Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: An immunohistochemical study with a monoclonal antibody
Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1996. Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: An immunohistochemical study with a monoclonal antibody. Neuroscience Letters. 202(3), 197–200.
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Journal Article
| Published
| English
Scopus indexed
Author
Neki, Akio;
Ohishi, Hitoshi;
Kaneko, Takeshi;
Shigemoto, RyuichiISTA 
;
Nakanishi, Shigetada;
Mizuno, Noboru
;
Nakanishi, Shigetada;
Mizuno, NoboruAbstract
A monoclonal antibody against a metabotropic glutamate receptor, mGluR2, was produced by using a glutathione S-transferase (GST) fusion protein containing an N-terminal sequence of rat mGluR2. Intense mGluR2-like immunoreactivity (mGluR2-LI) was seen mainly in neuropil of the cerebral cortical regions, hippocampus, olfactory bulb, some diencephalic nuclei, dorsal cochlear nucleus and cerebellar cortex. In the cerebellar cortex, mGluR2-LI was seen only in Golgi cells. In Ammon's hem, mGluR2-LI was marked in the stratum lucidum of CA3 and the stratum lacunosum-moleculare of CA1-CA3, but not detected in the stratum pyramidale. The results indicate that mGluR2 is located not only presynaptically but also postsynaptically.
Publishing Year
Date Published
1996-01-05
Journal Title
Neuroscience Letters
Publisher
Elsevier
Acknowledgement
We are grateful to Mr. Akira Uesugi for photographic help.
Volume
202
Issue
3
Page
197 - 200
ISSN
IST-REx-ID
Cite this
Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: An immunohistochemical study with a monoclonal antibody. Neuroscience Letters. 1996;202(3):197-200. doi:10.1016/0304-3940(95)12248-6
Neki, A., Ohishi, H., Kaneko, T., Shigemoto, R., Nakanishi, S., & Mizuno, N. (1996). Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: An immunohistochemical study with a monoclonal antibody. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(95)12248-6
Neki, Akio, Hitoshi Ohishi, Takeshi Kaneko, Ryuichi Shigemoto, Shigetada Nakanishi, and Noboru Mizuno. “Pre- and Postsynaptic Localization of a Metabotropic Glutamate Receptor, MGluR2, in the Rat Brain: An Immunohistochemical Study with a Monoclonal Antibody.” Neuroscience Letters. Elsevier, 1996. https://doi.org/10.1016/0304-3940(95)12248-6.
A. Neki, H. Ohishi, T. Kaneko, R. Shigemoto, S. Nakanishi, and N. Mizuno, “Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: An immunohistochemical study with a monoclonal antibody,” Neuroscience Letters, vol. 202, no. 3. Elsevier, pp. 197–200, 1996.
Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1996. Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: An immunohistochemical study with a monoclonal antibody. Neuroscience Letters. 202(3), 197–200.
Neki, Akio, et al. “Pre- and Postsynaptic Localization of a Metabotropic Glutamate Receptor, MGluR2, in the Rat Brain: An Immunohistochemical Study with a Monoclonal Antibody.” Neuroscience Letters, vol. 202, no. 3, Elsevier, 1996, pp. 197–200, doi:10.1016/0304-3940(95)12248-6.
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