NAD to the bone: How bacteria put phages under aRES-t … and how phages fight back
Williams-Jones D, Bravo JPK. 2026. NAD to the bone: How bacteria put phages under aRES-t … and how phages fight back. Cell Host & Microbe. 34(6), 978–980.
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Journal Article
| Published
| English
Scopus indexed
Corresponding author has ISTA affiliation
Department
Abstract
In this issue of Cell Host & Microbe, Osterman et al. discover aRES,1 a new family of bacterial immune proteins that deplete cellular NAD+, generating cleavage products that cannot be utilized by canonical phage NAD+ regeneration pathways. They identify the invader-specific trigger for aRES and characterize two distinct evolutionary countermeasures employed by phages to resist aRES.
Publishing Year
Date Published
2026-06-10
Journal Title
Cell Host & Microbe
Publisher
Elsevier
Acknowledgement
This work was supported by the Austrian Science Fund (FWF) (10.55776/PAT1617625).
Volume
34
Issue
6
Page
978-980
ISSN
eISSN
IST-REx-ID
Cite this
Williams-Jones D, Bravo JPK. NAD to the bone: How bacteria put phages under aRES-t … and how phages fight back. Cell Host & Microbe. 2026;34(6):978-980. doi:10.1016/j.chom.2026.05.013
Williams-Jones, D., & Bravo, J. P. K. (2026). NAD to the bone: How bacteria put phages under aRES-t … and how phages fight back. Cell Host & Microbe. Elsevier. https://doi.org/10.1016/j.chom.2026.05.013
Williams-Jones, Daniel, and Jack Peter Kelly Bravo. “NAD to the Bone: How Bacteria Put Phages under ARES-t … and How Phages Fight Back.” Cell Host & Microbe. Elsevier, 2026. https://doi.org/10.1016/j.chom.2026.05.013.
D. Williams-Jones and J. P. K. Bravo, “NAD to the bone: How bacteria put phages under aRES-t … and how phages fight back,” Cell Host & Microbe, vol. 34, no. 6. Elsevier, pp. 978–980, 2026.
Williams-Jones D, Bravo JPK. 2026. NAD to the bone: How bacteria put phages under aRES-t … and how phages fight back. Cell Host & Microbe. 34(6), 978–980.
Williams-Jones, Daniel, and Jack Peter Kelly Bravo. “NAD to the Bone: How Bacteria Put Phages under ARES-t … and How Phages Fight Back.” Cell Host & Microbe, vol. 34, no. 6, Elsevier, 2026, pp. 978–80, doi:10.1016/j.chom.2026.05.013.
PMID: 42269584
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