Carrie Bernecky
Bernecky Group
17 Publications
2025 | Epub ahead of print | Journal Article | IST-REx-ID: 19465
Bernecky, Carrie A, Understanding the machinery that reads the genome. Nature Reviews Molecular Cell Biology. 2025
View
| DOI
| PubMed | Europe PMC
2025 | Published | Journal Article | IST-REx-ID: 18778 |

Tluckova, Katarina, Mechanism of mammalian transcriptional repression by noncoding RNA. Nature Structural & Molecular Biology 32. 2025
[Published Version]
View
| Files available
| DOI
| WoS
2024 | Published | Journal Article | IST-REx-ID: 18553 |

Ramadhin AR, Lee S-H, Zhou D, et al. STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment. Molecular Cell. 2024;84(24):4740-4757.e12. doi:10.1016/j.molcel.2024.10.030
[Published Version]
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| Files available
| DOI
| PubMed | Europe PMC
2023 | Draft | Preprint | IST-REx-ID: 14644 |

Tluckova K, Testa Salmazo AP, Bernecky C. Mechanism of mammalian transcriptional repression by noncoding RNA. doi:10.15479/AT:ISTA:14644
[Submitted Version]
View
| Files available
| DOI
2022 | Published | Journal Article | IST-REx-ID: 12051 |

Daiß JL, Pilsl M, Straub K, et al. The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans. Life Science Alliance. 2022;5(11). doi:10.26508/lsa.202201568
[Published Version]
View
| Files available
| DOI
| WoS
2022 | Published | Journal Article | IST-REx-ID: 12143 |

Zapletal D, Taborska E, Pasulka J, Malik R, Kubicek K, Zanova M, Much C, Sebesta M, Buccheri V, Horvat F, Jenickova I, Prochazkova M, Prochazka J, Pinkas M, Novacek J, Joseph DF, Sedlacek R, Bernecky C, O’Carroll D, Stefl R, Svoboda P. 2022. Structural and functional basis of mammalian microRNA biogenesis by Dicer. Molecular Cell. 82(21), 4064–4079.e13.
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
2021 | Published | Journal Article | IST-REx-ID: 10163 |

Appel L-M, Franke V, Bruno M, Grishkovskaya I, Kasiliauskaite A, Kaufmann T, Schoeberl UE, Puchinger MG, Kostrhon S, Ebenwaldner C, Sebesta M, Beltzung E, Mechtler K, Lin G, Vlasova A, Leeb M, Pavri R, Stark A, Akalin A, Stefl R, Bernecky C, Djinovic-Carugo K, Slade D. 2021. PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC. Nature Communications. 12(1), 6078.
[Published Version]
View
| Files available
| DOI
| WoS
2017 | Published | Journal Article | IST-REx-ID: 600
Engel C, Gubbey T, Neyer S, et al. Structural basis of RNA polymerase I transcription initiation. Cell. 2017;169(1):120-131.e22. doi:10.1016/j.cell.2017.03.003
View
| DOI
2017 | Published | Journal Article | IST-REx-ID: 601 |

Xu Y, Bernecky C, Lee C, et al. Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex. Nature Communications. 2017;8. doi:10.1038/ncomms15741
[Published Version]
View
| Files available
| DOI
2017 | Published | Journal Article | IST-REx-ID: 603
Bernecky C, Plitzko J, Cramer P. Structure of a transcribing RNA polymerase II-DSIF complex reveals a multidentate DNA-RNA clamp. Nature Structural and Molecular Biology. 2017;24(10):809-815. doi:10.1038/nsmb.3465
View
| DOI
2016 | Published | Journal Article | IST-REx-ID: 602
Bernecky C, Herzog F, Baumeister W, Plitzko J, Cramer P. Structure of transcribing mammalian RNA polymerase II. Nature. 2016;529(7587):551-554. doi:10.1038/nature16482
View
| DOI
2015 | Published | Journal Article | IST-REx-ID: 594
Sainsbury S, Bernecky C, Cramer P. Structural basis of transcription initiation by RNA polymerase II. Nature Reviews Molecular Cell Biology. 2015;16(3):129-143. doi:10.1038/nrm3952
View
| DOI
2013 | Published | Journal Article | IST-REx-ID: 595 |

Bernecky C, Cramer P. Struggling to let go: A non-coding RNA directs its own extension and destruction. EMBO Journal. 2013;32(6):771-772. doi:10.1038/emboj.2013.36
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| DOI
| Download None (ext.)
2012 | Published | Journal Article | IST-REx-ID: 596 |

Bernecky C, Taatjes D. Activator-mediator binding stabilizes RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF assembly. Journal of Molecular Biology. 2012;417(5):387-394. doi:10.1016/j.jmb.2012.02.014
View
| DOI
| Download None (ext.)
2011 | Published | Journal Article | IST-REx-ID: 597
Bernecky C, Grob P, Ebmeier C, Nogales E, Taatjes D. Molecular architecture of the human Mediator-RNA polymerase II-TFIIF assembly. PLoS Biology. 2011;9(3). doi:10.1371/journal.pbio.1000603
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| DOI
2010 | Published | Journal Article | IST-REx-ID: 598 |

Meyer K, Lin S, Bernecky C, Gao Y, Taatjes D. P53 activates transcription by directing structural shifts in Mediator. Nature Structural and Molecular Biology. 2010;17(6):753-760. doi:10.1038/nsmb.1816
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| DOI
| Download None (ext.)
2009 | Published | Journal Article | IST-REx-ID: 599 |

Knuesel M, Meyer K, Bernecky C, Taatjes D. The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function. Genes and Development. 2009;23(4):439-451. doi:10.1101/gad.1767009
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| DOI
| Download None (ext.)
Grants
17 Publications
2025 | Epub ahead of print | Journal Article | IST-REx-ID: 19465
Bernecky, Carrie A, Understanding the machinery that reads the genome. Nature Reviews Molecular Cell Biology. 2025
View
| DOI
| PubMed | Europe PMC
2025 | Published | Journal Article | IST-REx-ID: 18778 |

Tluckova, Katarina, Mechanism of mammalian transcriptional repression by noncoding RNA. Nature Structural & Molecular Biology 32. 2025
[Published Version]
View
| Files available
| DOI
| WoS
2024 | Published | Journal Article | IST-REx-ID: 18553 |

Ramadhin AR, Lee S-H, Zhou D, et al. STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment. Molecular Cell. 2024;84(24):4740-4757.e12. doi:10.1016/j.molcel.2024.10.030
[Published Version]
View
| Files available
| DOI
| PubMed | Europe PMC
2023 | Draft | Preprint | IST-REx-ID: 14644 |

Tluckova K, Testa Salmazo AP, Bernecky C. Mechanism of mammalian transcriptional repression by noncoding RNA. doi:10.15479/AT:ISTA:14644
[Submitted Version]
View
| Files available
| DOI
2022 | Published | Journal Article | IST-REx-ID: 12051 |

Daiß JL, Pilsl M, Straub K, et al. The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans. Life Science Alliance. 2022;5(11). doi:10.26508/lsa.202201568
[Published Version]
View
| Files available
| DOI
| WoS
2022 | Published | Journal Article | IST-REx-ID: 12143 |

Zapletal D, Taborska E, Pasulka J, Malik R, Kubicek K, Zanova M, Much C, Sebesta M, Buccheri V, Horvat F, Jenickova I, Prochazkova M, Prochazka J, Pinkas M, Novacek J, Joseph DF, Sedlacek R, Bernecky C, O’Carroll D, Stefl R, Svoboda P. 2022. Structural and functional basis of mammalian microRNA biogenesis by Dicer. Molecular Cell. 82(21), 4064–4079.e13.
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
2021 | Published | Journal Article | IST-REx-ID: 10163 |

Appel L-M, Franke V, Bruno M, Grishkovskaya I, Kasiliauskaite A, Kaufmann T, Schoeberl UE, Puchinger MG, Kostrhon S, Ebenwaldner C, Sebesta M, Beltzung E, Mechtler K, Lin G, Vlasova A, Leeb M, Pavri R, Stark A, Akalin A, Stefl R, Bernecky C, Djinovic-Carugo K, Slade D. 2021. PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC. Nature Communications. 12(1), 6078.
[Published Version]
View
| Files available
| DOI
| WoS
2017 | Published | Journal Article | IST-REx-ID: 600
Engel C, Gubbey T, Neyer S, et al. Structural basis of RNA polymerase I transcription initiation. Cell. 2017;169(1):120-131.e22. doi:10.1016/j.cell.2017.03.003
View
| DOI
2017 | Published | Journal Article | IST-REx-ID: 601 |

Xu Y, Bernecky C, Lee C, et al. Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex. Nature Communications. 2017;8. doi:10.1038/ncomms15741
[Published Version]
View
| Files available
| DOI
2017 | Published | Journal Article | IST-REx-ID: 603
Bernecky C, Plitzko J, Cramer P. Structure of a transcribing RNA polymerase II-DSIF complex reveals a multidentate DNA-RNA clamp. Nature Structural and Molecular Biology. 2017;24(10):809-815. doi:10.1038/nsmb.3465
View
| DOI
2016 | Published | Journal Article | IST-REx-ID: 602
Bernecky C, Herzog F, Baumeister W, Plitzko J, Cramer P. Structure of transcribing mammalian RNA polymerase II. Nature. 2016;529(7587):551-554. doi:10.1038/nature16482
View
| DOI
2015 | Published | Journal Article | IST-REx-ID: 594
Sainsbury S, Bernecky C, Cramer P. Structural basis of transcription initiation by RNA polymerase II. Nature Reviews Molecular Cell Biology. 2015;16(3):129-143. doi:10.1038/nrm3952
View
| DOI
2013 | Published | Journal Article | IST-REx-ID: 595 |

Bernecky C, Cramer P. Struggling to let go: A non-coding RNA directs its own extension and destruction. EMBO Journal. 2013;32(6):771-772. doi:10.1038/emboj.2013.36
View
| DOI
| Download None (ext.)
2012 | Published | Journal Article | IST-REx-ID: 596 |

Bernecky C, Taatjes D. Activator-mediator binding stabilizes RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF assembly. Journal of Molecular Biology. 2012;417(5):387-394. doi:10.1016/j.jmb.2012.02.014
View
| DOI
| Download None (ext.)
2011 | Published | Journal Article | IST-REx-ID: 597
Bernecky C, Grob P, Ebmeier C, Nogales E, Taatjes D. Molecular architecture of the human Mediator-RNA polymerase II-TFIIF assembly. PLoS Biology. 2011;9(3). doi:10.1371/journal.pbio.1000603
View
| DOI
2010 | Published | Journal Article | IST-REx-ID: 598 |

Meyer K, Lin S, Bernecky C, Gao Y, Taatjes D. P53 activates transcription by directing structural shifts in Mediator. Nature Structural and Molecular Biology. 2010;17(6):753-760. doi:10.1038/nsmb.1816
View
| DOI
| Download None (ext.)
2009 | Published | Journal Article | IST-REx-ID: 599 |

Knuesel M, Meyer K, Bernecky C, Taatjes D. The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function. Genes and Development. 2009;23(4):439-451. doi:10.1101/gad.1767009
View
| DOI
| Download None (ext.)