Carrie Bernecky
Bernecky Group
17 Publications
2025 | Epub ahead of print | Journal Article | IST-REx-ID: 19465
Bernecky, Carrie A, Understanding the machinery that reads the genome. Nature Reviews Molecular Cell Biology. 2025
View
| DOI
| PubMed | Europe PMC
2025 | Published | Journal Article | IST-REx-ID: 18778 |

Tluckova, Katarina, Mechanism of mammalian transcriptional repression by noncoding RNA. Nature Structural & Molecular Biology 32. 2025
[Published Version]
View
| Files available
| DOI
| WoS
2024 | Published | Journal Article | IST-REx-ID: 18553 |

Ramadhin, Anisha R., et al. “STK19 Drives Transcription-Coupled Repair by Stimulating Repair Complex Stability, RNA Pol II Ubiquitylation, and TFIIH Recruitment.” Molecular Cell, vol. 84, no. 24, Elsevier, 2024, p. 4740–4757.e12, doi:10.1016/j.molcel.2024.10.030.
[Published Version]
View
| Files available
| DOI
| PubMed | Europe PMC
2023 | Draft | Preprint | IST-REx-ID: 14644 |

Tluckova, Katarina, et al. Mechanism of Mammalian Transcriptional Repression by Noncoding RNA. Institute of Science and Technology Austria, doi:10.15479/AT:ISTA:14644.
[Submitted Version]
View
| Files available
| DOI
2022 | Published | Journal Article | IST-REx-ID: 12051 |

Daiß, Julia L., et al. “The Human RNA Polymerase I Structure Reveals an HMG-like Docking Domain Specific to Metazoans.” Life Science Alliance, vol. 5, no. 11, e202201568, Life Science Alliance, 2022, doi:10.26508/lsa.202201568.
[Published Version]
View
| Files available
| DOI
| WoS
2022 | Published | Journal Article | IST-REx-ID: 12143 |

Zapletal D, Taborska E, Pasulka J, Malik R, Kubicek K, Zanova M, Much C, Sebesta M, Buccheri V, Horvat F, Jenickova I, Prochazkova M, Prochazka J, Pinkas M, Novacek J, Joseph DF, Sedlacek R, Bernecky C, O’Carroll D, Stefl R, Svoboda P. 2022. Structural and functional basis of mammalian microRNA biogenesis by Dicer. Molecular Cell. 82(21), 4064–4079.e13.
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
2021 | Published | Journal Article | IST-REx-ID: 10163 |

Appel L-M, Franke V, Bruno M, Grishkovskaya I, Kasiliauskaite A, Kaufmann T, Schoeberl UE, Puchinger MG, Kostrhon S, Ebenwaldner C, Sebesta M, Beltzung E, Mechtler K, Lin G, Vlasova A, Leeb M, Pavri R, Stark A, Akalin A, Stefl R, Bernecky C, Djinovic-Carugo K, Slade D. 2021. PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC. Nature Communications. 12(1), 6078.
[Published Version]
View
| Files available
| DOI
| WoS
2017 | Published | Journal Article | IST-REx-ID: 600
Engel, Christoph, et al. “Structural Basis of RNA Polymerase I Transcription Initiation.” Cell, vol. 169, no. 1, Cell Press, 2017, p. 120–131.e22, doi:10.1016/j.cell.2017.03.003.
View
| DOI
2017 | Published | Journal Article | IST-REx-ID: 601 |

Xu, Youwei, et al. “Architecture of the RNA Polymerase II-Paf1C-TFIIS Transcription Elongation Complex.” Nature Communications, vol. 8, 15741, Nature Publishing Group, 2017, doi:10.1038/ncomms15741.
[Published Version]
View
| Files available
| DOI
2017 | Published | Journal Article | IST-REx-ID: 603
Bernecky, Carrie, et al. “Structure of a Transcribing RNA Polymerase II-DSIF Complex Reveals a Multidentate DNA-RNA Clamp.” Nature Structural and Molecular Biology, vol. 24, no. 10, Nature Publishing Group, 2017, pp. 809–15, doi:10.1038/nsmb.3465.
View
| DOI
2016 | Published | Journal Article | IST-REx-ID: 602
Bernecky, Carrie, et al. “Structure of Transcribing Mammalian RNA Polymerase II.” Nature, vol. 529, no. 7587, Nature Publishing Group, 2016, pp. 551–54, doi:10.1038/nature16482.
View
| DOI
2015 | Published | Journal Article | IST-REx-ID: 594
Sainsbury, Sarah, et al. “Structural Basis of Transcription Initiation by RNA Polymerase II.” Nature Reviews Molecular Cell Biology, vol. 16, no. 3, Nature Publishing Group, 2015, pp. 129–43, doi:10.1038/nrm3952.
View
| DOI
2013 | Published | Journal Article | IST-REx-ID: 595 |

Bernecky, Carrie, and Patrick Cramer. “Struggling to Let Go: A Non-Coding RNA Directs Its Own Extension and Destruction.” EMBO Journal, vol. 32, no. 6, Wiley-Blackwell, 2013, pp. 771–72, doi:10.1038/emboj.2013.36.
View
| DOI
| Download None (ext.)
2012 | Published | Journal Article | IST-REx-ID: 596 |

Bernecky, Carrie, and Dylan Taatjes. “Activator-Mediator Binding Stabilizes RNA Polymerase II Orientation within the Human Mediator-RNA Polymerase II-TFIIF Assembly.” Journal of Molecular Biology, vol. 417, no. 5, Elsevier, 2012, pp. 387–94, doi:10.1016/j.jmb.2012.02.014.
View
| DOI
| Download None (ext.)
2011 | Published | Journal Article | IST-REx-ID: 597
Bernecky, Carrie, et al. “Molecular Architecture of the Human Mediator-RNA Polymerase II-TFIIF Assembly.” PLoS Biology, vol. 9, no. 3, Public Library of Science, 2011, doi:10.1371/journal.pbio.1000603.
View
| DOI
2010 | Published | Journal Article | IST-REx-ID: 598 |

Meyer, Krista, et al. “P53 Activates Transcription by Directing Structural Shifts in Mediator.” Nature Structural and Molecular Biology, vol. 17, no. 6, Nature Publishing Group, 2010, pp. 753–60, doi:10.1038/nsmb.1816.
View
| DOI
| Download None (ext.)
2009 | Published | Journal Article | IST-REx-ID: 599 |

Knuesel, Matthew, et al. “The Human CDK8 Subcomplex Is a Molecular Switch That Controls Mediator Coactivator Function.” Genes and Development, vol. 23, no. 4, Cold Spring Harbor Laboratory Press, 2009, pp. 439–51, doi:10.1101/gad.1767009.
View
| DOI
| Download None (ext.)
Grants
17 Publications
2025 | Epub ahead of print | Journal Article | IST-REx-ID: 19465
Bernecky, Carrie A, Understanding the machinery that reads the genome. Nature Reviews Molecular Cell Biology. 2025
View
| DOI
| PubMed | Europe PMC
2025 | Published | Journal Article | IST-REx-ID: 18778 |

Tluckova, Katarina, Mechanism of mammalian transcriptional repression by noncoding RNA. Nature Structural & Molecular Biology 32. 2025
[Published Version]
View
| Files available
| DOI
| WoS
2024 | Published | Journal Article | IST-REx-ID: 18553 |

Ramadhin, Anisha R., et al. “STK19 Drives Transcription-Coupled Repair by Stimulating Repair Complex Stability, RNA Pol II Ubiquitylation, and TFIIH Recruitment.” Molecular Cell, vol. 84, no. 24, Elsevier, 2024, p. 4740–4757.e12, doi:10.1016/j.molcel.2024.10.030.
[Published Version]
View
| Files available
| DOI
| PubMed | Europe PMC
2023 | Draft | Preprint | IST-REx-ID: 14644 |

Tluckova, Katarina, et al. Mechanism of Mammalian Transcriptional Repression by Noncoding RNA. Institute of Science and Technology Austria, doi:10.15479/AT:ISTA:14644.
[Submitted Version]
View
| Files available
| DOI
2022 | Published | Journal Article | IST-REx-ID: 12051 |

Daiß, Julia L., et al. “The Human RNA Polymerase I Structure Reveals an HMG-like Docking Domain Specific to Metazoans.” Life Science Alliance, vol. 5, no. 11, e202201568, Life Science Alliance, 2022, doi:10.26508/lsa.202201568.
[Published Version]
View
| Files available
| DOI
| WoS
2022 | Published | Journal Article | IST-REx-ID: 12143 |

Zapletal D, Taborska E, Pasulka J, Malik R, Kubicek K, Zanova M, Much C, Sebesta M, Buccheri V, Horvat F, Jenickova I, Prochazkova M, Prochazka J, Pinkas M, Novacek J, Joseph DF, Sedlacek R, Bernecky C, O’Carroll D, Stefl R, Svoboda P. 2022. Structural and functional basis of mammalian microRNA biogenesis by Dicer. Molecular Cell. 82(21), 4064–4079.e13.
[Published Version]
View
| Files available
| DOI
| WoS
| PubMed | Europe PMC
2021 | Published | Journal Article | IST-REx-ID: 10163 |

Appel L-M, Franke V, Bruno M, Grishkovskaya I, Kasiliauskaite A, Kaufmann T, Schoeberl UE, Puchinger MG, Kostrhon S, Ebenwaldner C, Sebesta M, Beltzung E, Mechtler K, Lin G, Vlasova A, Leeb M, Pavri R, Stark A, Akalin A, Stefl R, Bernecky C, Djinovic-Carugo K, Slade D. 2021. PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC. Nature Communications. 12(1), 6078.
[Published Version]
View
| Files available
| DOI
| WoS
2017 | Published | Journal Article | IST-REx-ID: 600
Engel, Christoph, et al. “Structural Basis of RNA Polymerase I Transcription Initiation.” Cell, vol. 169, no. 1, Cell Press, 2017, p. 120–131.e22, doi:10.1016/j.cell.2017.03.003.
View
| DOI
2017 | Published | Journal Article | IST-REx-ID: 601 |

Xu, Youwei, et al. “Architecture of the RNA Polymerase II-Paf1C-TFIIS Transcription Elongation Complex.” Nature Communications, vol. 8, 15741, Nature Publishing Group, 2017, doi:10.1038/ncomms15741.
[Published Version]
View
| Files available
| DOI
2017 | Published | Journal Article | IST-REx-ID: 603
Bernecky, Carrie, et al. “Structure of a Transcribing RNA Polymerase II-DSIF Complex Reveals a Multidentate DNA-RNA Clamp.” Nature Structural and Molecular Biology, vol. 24, no. 10, Nature Publishing Group, 2017, pp. 809–15, doi:10.1038/nsmb.3465.
View
| DOI
2016 | Published | Journal Article | IST-REx-ID: 602
Bernecky, Carrie, et al. “Structure of Transcribing Mammalian RNA Polymerase II.” Nature, vol. 529, no. 7587, Nature Publishing Group, 2016, pp. 551–54, doi:10.1038/nature16482.
View
| DOI
2015 | Published | Journal Article | IST-REx-ID: 594
Sainsbury, Sarah, et al. “Structural Basis of Transcription Initiation by RNA Polymerase II.” Nature Reviews Molecular Cell Biology, vol. 16, no. 3, Nature Publishing Group, 2015, pp. 129–43, doi:10.1038/nrm3952.
View
| DOI
2013 | Published | Journal Article | IST-REx-ID: 595 |

Bernecky, Carrie, and Patrick Cramer. “Struggling to Let Go: A Non-Coding RNA Directs Its Own Extension and Destruction.” EMBO Journal, vol. 32, no. 6, Wiley-Blackwell, 2013, pp. 771–72, doi:10.1038/emboj.2013.36.
View
| DOI
| Download None (ext.)
2012 | Published | Journal Article | IST-REx-ID: 596 |

Bernecky, Carrie, and Dylan Taatjes. “Activator-Mediator Binding Stabilizes RNA Polymerase II Orientation within the Human Mediator-RNA Polymerase II-TFIIF Assembly.” Journal of Molecular Biology, vol. 417, no. 5, Elsevier, 2012, pp. 387–94, doi:10.1016/j.jmb.2012.02.014.
View
| DOI
| Download None (ext.)
2011 | Published | Journal Article | IST-REx-ID: 597
Bernecky, Carrie, et al. “Molecular Architecture of the Human Mediator-RNA Polymerase II-TFIIF Assembly.” PLoS Biology, vol. 9, no. 3, Public Library of Science, 2011, doi:10.1371/journal.pbio.1000603.
View
| DOI
2010 | Published | Journal Article | IST-REx-ID: 598 |

Meyer, Krista, et al. “P53 Activates Transcription by Directing Structural Shifts in Mediator.” Nature Structural and Molecular Biology, vol. 17, no. 6, Nature Publishing Group, 2010, pp. 753–60, doi:10.1038/nsmb.1816.
View
| DOI
| Download None (ext.)
2009 | Published | Journal Article | IST-REx-ID: 599 |

Knuesel, Matthew, et al. “The Human CDK8 Subcomplex Is a Molecular Switch That Controls Mediator Coactivator Function.” Genes and Development, vol. 23, no. 4, Cold Spring Harbor Laboratory Press, 2009, pp. 439–51, doi:10.1101/gad.1767009.
View
| DOI
| Download None (ext.)