Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines

Project Period: 2022-01-01 – 2025-09-30
Funder: European Research Council
Acronym
NEPA
Principal Investigator
Department(s)
Saric Group
Grant Number
802960
Grant DOI
10.3030/802960
Funder
European Research Council
Funder Schema
H2020-ERC-StG
Funder Registry
10.13039/501100000781

21 Publications

2026 | Published | Journal Article | IST-REx-ID: 21369 | OA | PlanS
Structural defects in amyloid-β fibrils drive secondary nucleation
J. Hu, T. Scheidt, D. Thacker, E. Axell, E. Stemme, U. Łapińska, S. Wennmalm, G. Meisl, S. Curk, M. Andreasen, M. Vendruscolo, P. Arosio, A. Šarić, J.D. Schmit, T.P.J. Knowles, E. Sparr, S. Linse, T.C.T. Michaels, A.J. Dear, Nature Communications 17 (2026).
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
2025 | Published | Journal Article | IST-REx-ID: 20318 | OA
A tutorial for mesoscale computer simulations of lipid membranes: Tether pulling, tubulation and fluctuations
M. Muñoz Basagoiti, F.F. Frey, B. Meadowcroft, M. Santana de Freitas Amaral, A. Prada, A. Šarić, Soft Matter 21 (2025) 7736–7756.
[Published Version] View | Files available | DOI | WoS | arXiv
 
2025 | Published | Journal Article | IST-REx-ID: 20530 | OA | PlanS
Temporal and spatial coordination of DNA segregation and cell division in an archaeon
J. Parham, V. Sorichetti, A. Cezanne, S. Foo, Y.W. Kuo, B. Hoogenberg, A. Radoux-Mergault, E. Mawdesley, L.D. Gatward, J. Boulanger, U. Schulze, A. Šarić, B. Baum, Proceedings of the National Academy of Sciences 122 (2025) e2513939122.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 
2025 | Published | Journal Article | IST-REx-ID: 21235 | OA | PlanS
Charge distribution of the coating brush drives interchromosome attraction
V. Sorichetti, P. Robin, I. Palaia, A. Hernandez-Armendariz, S. Cuylen-Haering, A. Šarić, PRX Life 3 (2025).
[Published Version] View | Files available | DOI
 
2025 | Published | Journal Article | IST-REx-ID: 21251 | OA | PlanS
Balancing stability and flexibility when reshaping archaeal membranes
M. Santana de Freitas Amaral, F.F. Frey, X. Jiang, B. Baum, A. Šarić, ELife 14 (2025).
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
2025 | Published | Journal Article | IST-REx-ID: 21256 | OA | PlanS
Nonequilibrium remodeling of collagen IV networks in Silico
B. Meadowcroft, V. Sorichetti, E. Ratajczyk, F.L. Perez Verdugo, N. Khalilgharibi, Y. Mao, I. Palaia, A. Šarić, PRX Life 3 (2025).
[Published Version] View | Files available | DOI
 
2024 | Published | Journal Article | IST-REx-ID: 18072 | OA
A liquid-like coat mediates chromosome clustering during mitotic exit
A. Hernandez-Armendariz, V. Sorichetti, Y. Hayashi, Z. Koskova, A. Brunner, J. Ellenberg, A. Šarić, S. Cuylen-Haering, Molecular Cell 84 (2024) P3254–3270.E9.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 
2024 | Published | Journal Article | IST-REx-ID: 18526 | OA
Endosomal membrane budding patterns in plants
E. Weiner, E. Berryman, F.F. Frey, A.G. Solís, A. Leier, T.M. Lago, A. Šarić, M.S. Otegui, Proceedings of the National Academy of Sciences of the United States of America 121 (2024).
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 
2024 | Published | Journal Article | IST-REx-ID: 14844 | OA
Nonadditivity in interactions between three membrane-wrapped colloidal spheres
A. Azadbakht, B. Meadowcroft, J. Majek, A. Šarić, D.J. Kraft, Biophysical Journal 123 (2024) 307–316.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 
2024 | Published | Journal Article | IST-REx-ID: 15001 | OA
Self-replication of Aβ42 aggregates occurs on small and isolated fibril sites
S. Curk, J. Krausser, G. Meisl, D. Frenkel, S. Linse, T.C.T. Michaels, T.P.J. Knowles, A. Šarić, Proceedings of the National Academy of Sciences of the United States of America 121 (2024).
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 
2024 | Published | Journal Article | IST-REx-ID: 17239 | OA
In operando imaging electrostatic-driven disassembly and reassembly of collagen nanostructures
C. Garcia-Sacristan, V.G. Gisbert, K. Klein, A. Šarić, R. Garcia, ACS Nano 18 (2024) 18485–18492.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 
2024 | Published | Journal Article | IST-REx-ID: 17460 | OA
Self-organization of mortal filaments and its role in bacterial division ring formation
C.E. Vanhille-Campos, K.D. Whitley, P. Radler, M. Loose, S. Holden, A. Šarić, Nature Physics 20 (2024) 1670–1678.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 
2024 | Draft | Preprint | IST-REx-ID: 18670 | OA
Stability vs flexibility: Reshaping archaeal membranes in silico
M. Santana de Freitas Amaral, F.F. Frey, X. Jiang, B. Baum, A. Šarić, BioRxiv (n.d.).
[Preprint] View | Files available | DOI | Download Preprint (ext.)
 
2023 | Published | Journal Article | IST-REx-ID: 13971 | OA
Unconventional colloidal aggregation in chiral bacterial baths
D. Grober, I. Palaia, M.C. Ucar, E.B. Hannezo, A. Šarić, J.A. Palacci, Nature Physics 19 (2023) 1680–1688.
[Published Version] View | Files available | DOI | WoS
 
2023 | Published | Journal Article | IST-REx-ID: 12708 | OA
Steering self-organisation through confinement
Araújo NAM, Janssen LMC, Barois T, Boffetta G, Cohen I, Corbetta A, Dauchot O, Dijkstra M, Durham WM, Dussutour A, Garnier S, Gelderblom H, Golestanian R, Isa L, Koenderink GH, Löwen H, Metzler R, Polin M, Royall CP, Šarić A, Sengupta A, Sykes C, Trianni V, Tuval I, Vogel N, Yeomans JM, Zuriguel I, Marin A, Volpe G. 2023. Steering self-organisation through confinement. Soft Matter. 19, 1695–1704.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC | arXiv
 
2023 | Published | Journal Article | IST-REx-ID: 12756 | OA
The patterned assembly and stepwise Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell division
F. Hurtig, T.C.Q. Burgers, A. Cezanne, X. Jiang, F.N. Mol, J. Traparić, A.A. Pulschen, T. Nierhaus, G. Tarrason-Risa, L. Harker-Kirschneck, J. Löwe, A. Šarić, R. Vlijm, B. Baum, Science Advances 9 (2023).
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 
2023 | Published | Journal Article | IST-REx-ID: 13094 | OA
Wrapping pathways of anisotropic dumbbell particles by Giant Unilamellar Vesicles
A. Azadbakht, B. Meadowcroft, T. Varkevisser, A. Šarić, D.J. Kraft, Nano Letters 23 (2023) 4267–4273.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 
2022 | Published | Journal Article | IST-REx-ID: 11841 | OA
Adsorption free energy predicts amyloid protein nucleation rates
Z. Toprakcioglu, A. Kamada, T.C.T. Michaels, M. Xie, J. Krausser, J. Wei, A. Šarić, M. Vendruscolo, T.P.J. Knowles, Proceedings of the National Academy of Sciences of the United States of America 119 (2022).
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 
2022 | Published | Journal Article | IST-REx-ID: 12108 | OA
Mechanochemical rules for shape-shifting filaments that remodel membranes
B. Meadowcroft, I. Palaia, A.K. Pfitzner, A. Roux, B. Baum, A. Šarić, Physical Review Letters 129 (2022).
[Preprint] View | DOI | Download Preprint (ext.) | WoS | PubMed | Europe PMC
 
2022 | Published | Journal Article | IST-REx-ID: 12152 | OA
Modelling membrane reshaping by staged polymerization of ESCRT-III filaments
X. Jiang, L. Harker-Kirschneck, C.E. Vanhille-Campos, A.-K. Pfitzner, E. Lominadze, A. Roux, B. Baum, A. Šarić, PLOS Computational Biology 18 (2022).
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 

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