Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance
Ku SP, Atucha E, Alavi N, Mulla-Osman H, Kayumova R, Yoshida M, Csicsvari JL, Sauvage MM. 2024. Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance. Cell Reports. 43(6), 114276.
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Journal Article
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Author
Ku, Shih Pi;
Atucha, Erika;
Alavi, Nico;
Mulla-Osman, Halla;
Kayumova, Rukhshona;
Yoshida, Motoharu;
Csicsvari, Jozsef LISTA 
;
Sauvage, Magdalena M.
;
Sauvage, Magdalena M.Department
Abstract
How the coordination of neuronal spiking and brain rhythms between hippocampal subregions supports memory function remains elusive. We studied the interregional coordination of CA3 neuronal spiking with CA1 theta oscillations by recording electrophysiological signals along the proximodistal axis of the hippocampus in rats that were performing a high-memory-demand recognition memory task adapted from humans. We found that CA3 population spiking occurs preferentially at the peak of distal CA1 theta oscillations when memory was tested but only when previously encountered stimuli were presented. In addition, decoding analyses revealed that only population cell firing of proximal CA3 together with that of distal CA1 can predict performance at test in the present non-spatial task. Overall, our work demonstrates an important role for the synchronization of CA3 neuronal activity with CA1 theta oscillations during memory testing.
Publishing Year
Date Published
2024-06-25
Journal Title
Cell Reports
Publisher
Elsevier
Acknowledgement
We would like to thank J. Maiwald for her assistance in animal behavior training, experiments, and brain slice preparation; D. Koch for her assistance in recording drive building and brain slicing; K. Kaefer and J. Wallenschus (IST Austria) for their initial technical support; S. Mikulovich for her comments on an early version of the manuscript; C. Reichert for his comments on SVM analyses; and J. Pakan for English proofreading. This project is funded by the DFG (CRC 779 and CRC 1436).
Volume
43
Issue
6
Article Number
114276
eISSN
IST-REx-ID
Cite this
Ku SP, Atucha E, Alavi N, et al. Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance. Cell Reports. 2024;43(6). doi:10.1016/j.celrep.2024.114276
Ku, S. P., Atucha, E., Alavi, N., Mulla-Osman, H., Kayumova, R., Yoshida, M., … Sauvage, M. M. (2024). Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance. Cell Reports. Elsevier. https://doi.org/10.1016/j.celrep.2024.114276
Ku, Shih Pi, Erika Atucha, Nico Alavi, Halla Mulla-Osman, Rukhshona Kayumova, Motoharu Yoshida, Jozsef L Csicsvari, and Magdalena M. Sauvage. “Phase Locking of Hippocampal CA3 Neurons to Distal CA1 Theta Oscillations Selectively Predicts Memory Performance.” Cell Reports. Elsevier, 2024. https://doi.org/10.1016/j.celrep.2024.114276.
S. P. Ku et al., “Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance,” Cell Reports, vol. 43, no. 6. Elsevier, 2024.
Ku SP, Atucha E, Alavi N, Mulla-Osman H, Kayumova R, Yoshida M, Csicsvari JL, Sauvage MM. 2024. Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance. Cell Reports. 43(6), 114276.
Ku, Shih Pi, et al. “Phase Locking of Hippocampal CA3 Neurons to Distal CA1 Theta Oscillations Selectively Predicts Memory Performance.” Cell Reports, vol. 43, no. 6, 114276, Elsevier, 2024, doi:10.1016/j.celrep.2024.114276.
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