Jack Bravo

28 Publications

Mark all

[28]
2025 | Published | Journal Article | IST-REx-ID: 18848 | OA
Ocampo RF, Bravo JPK, Dangerfield TL, et al. DNA targeting by compact Cas9d and its resurrected ancestor. Nature Communications. 2025;16. doi:10.1038/s41467-024-55573-4
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
[27]
2025 | In Press | Journal Article | IST-REx-ID: 20143 | OA | PlanS
Zhang Z, Todeschini TC, Wu Y, et al. Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites. Cell. doi:10.1016/j.cell.2025.07.002
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[26]
2024 | Published | Journal Article | IST-REx-ID: 17113 | OA
Hibshman GN, Bravo JPK, Hooper MM, et al. Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9. Nature Communications. 2024;15. doi:10.1038/s41467-024-47830-3
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[25]
2024 | Published | Journal Article | IST-REx-ID: 17114 | OA
Schwartz EA, Bravo JPK, Ahsan M, et al. RNA targeting and cleavage by the type III-Dv CRISPR effector complex. Nature Communications. 2024;15. doi:10.1038/s41467-024-47506-y
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[24]
2024 | Published | Journal Article | IST-REx-ID: 18545 | OA
Degtev D, Bravo JPK, Emmanouilidi A, et al. Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles. Nature Communications. 2024;15. doi:10.1038/s41467-024-53418-8
[Published Version] View | Files available | DOI
 
[23]
2024 | Published | Journal Article | IST-REx-ID: 17111
Kamatar A, Bravo JPK, Yuan F, et al. Lipid droplets as substrates for protein phase separation. Biophysical Journal. 2024;123(11):1494-1507. doi:10.1016/j.bpj.2024.03.015
View | DOI | PubMed | Europe PMC
 
[22]
2024 | Published | Journal Article | IST-REx-ID: 15372 | OA
Hibshman GN, Bravo JPK, Hooper MM, et al. Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9. Nature Communications. 2024;15. doi:10.1038/s41467-024-47830-3
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
[21]
2024 | Published | Journal Article | IST-REx-ID: 17442 | OA
Bravo JPK, Ramos DA, Fregoso Ocampo R, Ingram C, Taylor DW. Plasmid targeting and destruction by the DdmDE bacterial defence system. Nature. 2024;630(8018):961-967. doi:10.1038/s41586-024-07515-9
[Submitted Version] View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
[20]
2024 | Published | Journal Article | IST-REx-ID: 17494 | OA
Bravo JPK. Anti-plasmid immunity: A key to pathogen success? Future Microbiology. 2024;19(15):1269-1272. doi:10.1080/17460913.2024.2389720
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[19]
2023 | Published | Preprint | IST-REx-ID: 17112 | OA
Steens JA, Bravo JPK, Salazar CRP, et al. Type III-B CRISPR-Cas signaling-based cascade of proteolytic cleavages. bioRxiv. 2023. doi:10.1101/2023.06.23.546230
[Preprint] View | DOI | Download Preprint (ext.)
 
[18]
2023 | Published | Journal Article | IST-REx-ID: 15129 | OA
O’Brien RE, Bravo JPK, Ramos D, Hibshman GN, Wright JT, Taylor DW. Structural snapshots of R-loop formation by a type I-C CRISPR Cascade. Molecular Cell. 2023;83(5):746-758.e5. doi:10.1016/j.molcel.2023.01.024
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[17]
2023 | Published | Journal Article | IST-REx-ID: 15130 | OA
Bravo JPK, Hallmark T, Naegle B, Beisel CL, Jackson RN, Taylor DW. RNA targeting unleashes indiscriminate nuclease activity of CRISPR–Cas12a2. Nature. 2023;613(7944):582-587. doi:10.1038/s41586-022-05560-w
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[16]
2022 | Published | Preprint | IST-REx-ID: 17115 | OA
O’Brien RE, Bravo JPK, Ramos D, Hibshman GN, Wright JT, Taylor DW. Modes of inhibition used by phage anti-CRISPRs to evade type I-C Cascade. bioRxiv. 2022. doi:10.1101/2022.06.15.496202
[Preprint] View | DOI | Download Preprint (ext.)
 
[15]
2022 | Submitted | Preprint | IST-REx-ID: 17116 | OA
Schwartz EA, Bravo JPK, Macias LA, et al. Assembly of multi-subunit fusion proteins into the RNA-targeting type III-D CRISPR-Cas effector complex. bioRxiv. doi:10.1101/2022.06.13.496011
[Preprint] View | DOI | Download Preprint (ext.)
 
[14]
2022 | Published | Preprint | IST-REx-ID: 17117 | OA
Bravo JPK, Hallmark T, Naegle B, Beisel CL, Jackson RN, Taylor DW. Large-scale structural rearrangements unleash indiscriminate nuclease activity of CRISPR-Cas12a2. bioRxiv. 2022. doi:10.1101/2022.06.13.495754
[Preprint] View | DOI | Download Preprint (ext.)
 
[13]
2022 | Published | Journal Article | IST-REx-ID: 15131 | OA
Yelland JN, Bravo JPK, Black JJ, Taylor DW, Johnson AW. A single 2′-O-methylation of ribosomal RNA gates assembly of a functional ribosome. Nature Structural & Molecular Biology. 2022;30:91-98. doi:10.1038/s41594-022-00891-8
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[12]
2022 | Published | Journal Article | IST-REx-ID: 15132
Bravo JPK, Hibshman GN, Taylor DW. Constructing next-generation CRISPR–Cas tools from structural blueprints. Current Opinion in Biotechnology. 2022;78. doi:10.1016/j.copbio.2022.102839
View | DOI | PubMed | Europe PMC
 
[11]
2022 | Published | Journal Article | IST-REx-ID: 15133 | OA
Bravo JPK, Aparicio-Maldonado C, Nobrega FL, Brouns SJJ, Taylor DW. Structural basis for broad anti-phage immunity by DISARM. Nature Communications. 2022;13. doi:10.1038/s41467-022-30673-1
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[10]
2022 | Published | Journal Article | IST-REx-ID: 15134 | OA
Schwartz EA, McBride TM, Bravo JPK, et al. Structural rearrangements allow nucleic acid discrimination by type I-D Cascade. Nature Communications. 2022;13. doi:10.1038/s41467-022-30402-8
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[9]
2022 | Published | Journal Article | IST-REx-ID: 15136 | OA
Bravo JPK, Liu M-S, Hibshman GN, et al. Structural basis for mismatch surveillance by CRISPR–Cas9. Nature. 2022;603(7900):343-347. doi:10.1038/s41586-022-04470-1
[Published Version] View | Files available | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[8]
2022 | Published | Journal Article | IST-REx-ID: 15144
Bravo JPK. SuperFi-Cas9 exceeds fidelity, matches speed of original Cas9. Genetic Engineering & Biotechnology News. 2022;42(4):12. doi:10.1089/gen.42.04.03
View | DOI
 
[7]
2021 | Published | Journal Article | IST-REx-ID: 15137 | OA
Steens JA, Zhu Y, Taylor DW, et al. SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation. Nature Communications. 2021;12. doi:10.1038/s41467-021-25337-5
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[6]
2021 | Published | Journal Article | IST-REx-ID: 15138 | OA
Geiger F, Acker J, Papa G, et al. Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses. The EMBO Journal. 2021;40(21). doi:10.15252/embj.2021107711
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[5]
2021 | Published | Journal Article | IST-REx-ID: 15139 | OA
Bravo JPK, Bartnik K, Venditti L, et al. Structural basis of rotavirus RNA chaperone displacement and RNA annealing. Proceedings of the National Academy of Sciences. 2021;118(41). doi:10.1073/pnas.2100198118
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[4]
2021 | Published | Journal Article | IST-REx-ID: 15140 | OA
Bravo JPK, Dangerfield TL, Taylor DW, Johnson KA. Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication. Molecular Cell. 2021;81(7):1548-1552.e4. doi:10.1016/j.molcel.2021.01.035
[Preprint] View | DOI | Download Preprint (ext.) | PubMed | Europe PMC
 
[3]
2021 | Published | Journal Article | IST-REx-ID: 15141 | OA
Zhou Y, Bravo JPK, Taylor HN, et al. Structure of a type IV CRISPR-Cas ribonucleoprotein complex. iScience. 2021;24(3). doi:10.1016/j.isci.2021.102201
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[2]
2020 | Published | Journal Article | IST-REx-ID: 15142 | OA
O’Brien RE, Santos IC, Wrapp D, et al. Structural basis for assembly of non-canonical small subunits into type I-C Cascade. Nature Communications. 2020;11. doi:10.1038/s41467-020-19785-8
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[1]
2018 | Published | Journal Article | IST-REx-ID: 15143 | OA
Bravo JPK, Borodavka A, Barth A, et al. Stability of local secondary structure determines selectivity of viral RNA chaperones. Nucleic Acids Research. 2018;46(15):7924-7937. doi:10.1093/nar/gky394
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
Marked Publication(s)

Search

Filter Publications

Display / Sort

Citation Style: AMA

Export / Embed

Grants


28 Publications

Mark all

[28]
2025 | Published | Journal Article | IST-REx-ID: 18848 | OA
Ocampo RF, Bravo JPK, Dangerfield TL, et al. DNA targeting by compact Cas9d and its resurrected ancestor. Nature Communications. 2025;16. doi:10.1038/s41467-024-55573-4
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
[27]
2025 | In Press | Journal Article | IST-REx-ID: 20143 | OA | PlanS
Zhang Z, Todeschini TC, Wu Y, et al. Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites. Cell. doi:10.1016/j.cell.2025.07.002
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[26]
2024 | Published | Journal Article | IST-REx-ID: 17113 | OA
Hibshman GN, Bravo JPK, Hooper MM, et al. Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9. Nature Communications. 2024;15. doi:10.1038/s41467-024-47830-3
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[25]
2024 | Published | Journal Article | IST-REx-ID: 17114 | OA
Schwartz EA, Bravo JPK, Ahsan M, et al. RNA targeting and cleavage by the type III-Dv CRISPR effector complex. Nature Communications. 2024;15. doi:10.1038/s41467-024-47506-y
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[24]
2024 | Published | Journal Article | IST-REx-ID: 18545 | OA
Degtev D, Bravo JPK, Emmanouilidi A, et al. Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles. Nature Communications. 2024;15. doi:10.1038/s41467-024-53418-8
[Published Version] View | Files available | DOI
 
[23]
2024 | Published | Journal Article | IST-REx-ID: 17111
Kamatar A, Bravo JPK, Yuan F, et al. Lipid droplets as substrates for protein phase separation. Biophysical Journal. 2024;123(11):1494-1507. doi:10.1016/j.bpj.2024.03.015
View | DOI | PubMed | Europe PMC
 
[22]
2024 | Published | Journal Article | IST-REx-ID: 15372 | OA
Hibshman GN, Bravo JPK, Hooper MM, et al. Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9. Nature Communications. 2024;15. doi:10.1038/s41467-024-47830-3
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
[21]
2024 | Published | Journal Article | IST-REx-ID: 17442 | OA
Bravo JPK, Ramos DA, Fregoso Ocampo R, Ingram C, Taylor DW. Plasmid targeting and destruction by the DdmDE bacterial defence system. Nature. 2024;630(8018):961-967. doi:10.1038/s41586-024-07515-9
[Submitted Version] View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
[20]
2024 | Published | Journal Article | IST-REx-ID: 17494 | OA
Bravo JPK. Anti-plasmid immunity: A key to pathogen success? Future Microbiology. 2024;19(15):1269-1272. doi:10.1080/17460913.2024.2389720
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[19]
2023 | Published | Preprint | IST-REx-ID: 17112 | OA
Steens JA, Bravo JPK, Salazar CRP, et al. Type III-B CRISPR-Cas signaling-based cascade of proteolytic cleavages. bioRxiv. 2023. doi:10.1101/2023.06.23.546230
[Preprint] View | DOI | Download Preprint (ext.)
 
[18]
2023 | Published | Journal Article | IST-REx-ID: 15129 | OA
O’Brien RE, Bravo JPK, Ramos D, Hibshman GN, Wright JT, Taylor DW. Structural snapshots of R-loop formation by a type I-C CRISPR Cascade. Molecular Cell. 2023;83(5):746-758.e5. doi:10.1016/j.molcel.2023.01.024
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[17]
2023 | Published | Journal Article | IST-REx-ID: 15130 | OA
Bravo JPK, Hallmark T, Naegle B, Beisel CL, Jackson RN, Taylor DW. RNA targeting unleashes indiscriminate nuclease activity of CRISPR–Cas12a2. Nature. 2023;613(7944):582-587. doi:10.1038/s41586-022-05560-w
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[16]
2022 | Published | Preprint | IST-REx-ID: 17115 | OA
O’Brien RE, Bravo JPK, Ramos D, Hibshman GN, Wright JT, Taylor DW. Modes of inhibition used by phage anti-CRISPRs to evade type I-C Cascade. bioRxiv. 2022. doi:10.1101/2022.06.15.496202
[Preprint] View | DOI | Download Preprint (ext.)
 
[15]
2022 | Submitted | Preprint | IST-REx-ID: 17116 | OA
Schwartz EA, Bravo JPK, Macias LA, et al. Assembly of multi-subunit fusion proteins into the RNA-targeting type III-D CRISPR-Cas effector complex. bioRxiv. doi:10.1101/2022.06.13.496011
[Preprint] View | DOI | Download Preprint (ext.)
 
[14]
2022 | Published | Preprint | IST-REx-ID: 17117 | OA
Bravo JPK, Hallmark T, Naegle B, Beisel CL, Jackson RN, Taylor DW. Large-scale structural rearrangements unleash indiscriminate nuclease activity of CRISPR-Cas12a2. bioRxiv. 2022. doi:10.1101/2022.06.13.495754
[Preprint] View | DOI | Download Preprint (ext.)
 
[13]
2022 | Published | Journal Article | IST-REx-ID: 15131 | OA
Yelland JN, Bravo JPK, Black JJ, Taylor DW, Johnson AW. A single 2′-O-methylation of ribosomal RNA gates assembly of a functional ribosome. Nature Structural & Molecular Biology. 2022;30:91-98. doi:10.1038/s41594-022-00891-8
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[12]
2022 | Published | Journal Article | IST-REx-ID: 15132
Bravo JPK, Hibshman GN, Taylor DW. Constructing next-generation CRISPR–Cas tools from structural blueprints. Current Opinion in Biotechnology. 2022;78. doi:10.1016/j.copbio.2022.102839
View | DOI | PubMed | Europe PMC
 
[11]
2022 | Published | Journal Article | IST-REx-ID: 15133 | OA
Bravo JPK, Aparicio-Maldonado C, Nobrega FL, Brouns SJJ, Taylor DW. Structural basis for broad anti-phage immunity by DISARM. Nature Communications. 2022;13. doi:10.1038/s41467-022-30673-1
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[10]
2022 | Published | Journal Article | IST-REx-ID: 15134 | OA
Schwartz EA, McBride TM, Bravo JPK, et al. Structural rearrangements allow nucleic acid discrimination by type I-D Cascade. Nature Communications. 2022;13. doi:10.1038/s41467-022-30402-8
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[9]
2022 | Published | Journal Article | IST-REx-ID: 15136 | OA
Bravo JPK, Liu M-S, Hibshman GN, et al. Structural basis for mismatch surveillance by CRISPR–Cas9. Nature. 2022;603(7900):343-347. doi:10.1038/s41586-022-04470-1
[Published Version] View | Files available | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[8]
2022 | Published | Journal Article | IST-REx-ID: 15144
Bravo JPK. SuperFi-Cas9 exceeds fidelity, matches speed of original Cas9. Genetic Engineering & Biotechnology News. 2022;42(4):12. doi:10.1089/gen.42.04.03
View | DOI
 
[7]
2021 | Published | Journal Article | IST-REx-ID: 15137 | OA
Steens JA, Zhu Y, Taylor DW, et al. SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation. Nature Communications. 2021;12. doi:10.1038/s41467-021-25337-5
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[6]
2021 | Published | Journal Article | IST-REx-ID: 15138 | OA
Geiger F, Acker J, Papa G, et al. Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses. The EMBO Journal. 2021;40(21). doi:10.15252/embj.2021107711
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[5]
2021 | Published | Journal Article | IST-REx-ID: 15139 | OA
Bravo JPK, Bartnik K, Venditti L, et al. Structural basis of rotavirus RNA chaperone displacement and RNA annealing. Proceedings of the National Academy of Sciences. 2021;118(41). doi:10.1073/pnas.2100198118
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[4]
2021 | Published | Journal Article | IST-REx-ID: 15140 | OA
Bravo JPK, Dangerfield TL, Taylor DW, Johnson KA. Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication. Molecular Cell. 2021;81(7):1548-1552.e4. doi:10.1016/j.molcel.2021.01.035
[Preprint] View | DOI | Download Preprint (ext.) | PubMed | Europe PMC
 
[3]
2021 | Published | Journal Article | IST-REx-ID: 15141 | OA
Zhou Y, Bravo JPK, Taylor HN, et al. Structure of a type IV CRISPR-Cas ribonucleoprotein complex. iScience. 2021;24(3). doi:10.1016/j.isci.2021.102201
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[2]
2020 | Published | Journal Article | IST-REx-ID: 15142 | OA
O’Brien RE, Santos IC, Wrapp D, et al. Structural basis for assembly of non-canonical small subunits into type I-C Cascade. Nature Communications. 2020;11. doi:10.1038/s41467-020-19785-8
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[1]
2018 | Published | Journal Article | IST-REx-ID: 15143 | OA
Bravo JPK, Borodavka A, Barth A, et al. Stability of local secondary structure determines selectivity of viral RNA chaperones. Nucleic Acids Research. 2018;46(15):7924-7937. doi:10.1093/nar/gky394
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
Marked Publication(s)

Search

Filter Publications

Display / Sort

Citation Style: AMA

Export / Embed