Jack Bravo

Bravo Group

23 Publications

Mark all

[23]
2024 | Journal Article | IST-REx-ID: 15372 | OA
Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9
G.N. Hibshman, J.P.K. Bravo, M.M. Hooper, T.L. Dangerfield, H. Zhang, I.J. Finkelstein, K.A. Johnson, D.W. Taylor, Nature Communications 15 (2024).
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
[22]
2024 | Journal Article | IST-REx-ID: 17114 | OA
RNA targeting and cleavage by the type III-Dv CRISPR effector complex
E.A. Schwartz, J.P.K. Bravo, M. Ahsan, L.A. Macias, C.L. McCafferty, T.L. Dangerfield, J.N. Walker, J.S. Brodbelt, G. Palermo, P.C. Fineran, R.D. Fagerlund, D.W. Taylor, Nature Communications 15 (2024).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[21]
2024 | Journal Article | IST-REx-ID: 17113 | OA
Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9
G.N. Hibshman, J.P.K. Bravo, M.M. Hooper, T.L. Dangerfield, H. Zhang, I.J. Finkelstein, K.A. Johnson, D.W. Taylor, Nature Communications 15 (2024).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[20]
2024 | Journal Article | IST-REx-ID: 17111
Lipid droplets as substrates for protein phase separation
A. Kamatar, J.P.K. Bravo, F. Yuan, L. Wang, E.M. Lafer, D.W. Taylor, J.C. Stachowiak, S.H. Parekh, Biophysical Journal (n.d.).
View | DOI | PubMed | Europe PMC
 
[19]
2023 | Journal Article | IST-REx-ID: 15130 | OA
RNA targeting unleashes indiscriminate nuclease activity of CRISPR–Cas12a2
J.P.K. Bravo, T. Hallmark, B. Naegle, C.L. Beisel, R.N. Jackson, D.W. Taylor, Nature 613 (2023) 582–587.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[18]
2023 | Journal Article | IST-REx-ID: 15129 | OA
Structural snapshots of R-loop formation by a type I-C CRISPR Cascade
R.E. O’Brien, J.P.K. Bravo, D. Ramos, G.N. Hibshman, J.T. Wright, D.W. Taylor, Molecular Cell 83 (2023) 746–758.e5.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[17]
2023 | Preprint | IST-REx-ID: 17112 | OA
Type III-B CRISPR-Cas signaling-based cascade of proteolytic cleavages
J.A. Steens, J.P.K. Bravo, C.R.P. Salazar, C. Yildiz, A.M. Amieiro, S. Köstlbacher, S.H.P. Prinsen, C. Patinios, A. Bardis, A. Barendregt, R.A. Scheltema, T.J.G. Ettema, J. van der Oost, D.W. Taylor, R.H.J. Staals, BioRxiv (2023).
[Preprint] View | DOI | Download Preprint (ext.)
 
[16]
2022 | Journal Article | IST-REx-ID: 15144
SuperFi-Cas9 exceeds fidelity, matches speed of original Cas9
J.P.K. Bravo, Genetic Engineering & Biotechnology News 42 (2022) 12.
View | DOI
 
[15]
2022 | Journal Article | IST-REx-ID: 15134 | OA
Structural rearrangements allow nucleic acid discrimination by type I-D Cascade
E.A. Schwartz, T.M. McBride, J.P.K. Bravo, D. Wrapp, P.C. Fineran, R.D. Fagerlund, D.W. Taylor, Nature Communications 13 (2022).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[14]
2022 | Journal Article | IST-REx-ID: 15131 | OA
A single 2′-O-methylation of ribosomal RNA gates assembly of a functional ribosome
J.N. Yelland, J.P.K. Bravo, J.J. Black, D.W. Taylor, A.W. Johnson, Nature Structural & Molecular Biology 30 (2022) 91–98.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[13]
2022 | Journal Article | IST-REx-ID: 15133 | OA
Structural basis for broad anti-phage immunity by DISARM
J.P.K. Bravo, C. Aparicio-Maldonado, F.L. Nobrega, S.J.J. Brouns, D.W. Taylor, Nature Communications 13 (2022).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[12]
2022 | Journal Article | IST-REx-ID: 15132
Constructing next-generation CRISPR–Cas tools from structural blueprints
J.P.K. Bravo, G.N. Hibshman, D.W. Taylor, Current Opinion in Biotechnology 78 (2022).
View | DOI | PubMed | Europe PMC
 
[11]
2022 | Journal Article | IST-REx-ID: 15136 | OA
Structural basis for mismatch surveillance by CRISPR–Cas9
J.P.K. Bravo, M.-S. Liu, G.N. Hibshman, T.L. Dangerfield, K. Jung, R.S. McCool, K.A. Johnson, D.W. Taylor, Nature 603 (2022) 343–347.
[Published Version] View | Files available | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[10]
2022 | Preprint | IST-REx-ID: 17116 | OA
Assembly of multi-subunit fusion proteins into the RNA-targeting type III-D CRISPR-Cas effector complex
E.A. Schwartz, J.P.K. Bravo, L.A. Macias, C.L. McCafferty, T.L. Dangerfield, J.N. Walker, J.S. Brodbelt, P.C. Fineran, R.D. Fagerlund, D.W. Taylor, BioRxiv (n.d.).
[Preprint] View | DOI | Download Preprint (ext.)
 
[9]
2022 | Preprint | IST-REx-ID: 17115 | OA
Modes of inhibition used by phage anti-CRISPRs to evade type I-C Cascade
R.E. O’Brien, J.P.K. Bravo, D. Ramos, G.N. Hibshman, J.T. Wright, D.W. Taylor, BioRxiv (2022).
[Preprint] View | DOI | Download Preprint (ext.)
 
[8]
2022 | Preprint | IST-REx-ID: 17117 | OA
Large-scale structural rearrangements unleash indiscriminate nuclease activity of CRISPR-Cas12a2
J.P.K. Bravo, T. Hallmark, B. Naegle, C.L. Beisel, R.N. Jackson, D.W. Taylor, BioRxiv (2022).
[Preprint] View | DOI | Download Preprint (ext.)
 
[7]
2021 | Journal Article | IST-REx-ID: 15141 | OA
Structure of a type IV CRISPR-Cas ribonucleoprotein complex
Y. Zhou, J.P.K. Bravo, H.N. Taylor, J.A. Steens, R.N. Jackson, R.H.J. Staals, D.W. Taylor, IScience 24 (2021).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[6]
2021 | Journal Article | IST-REx-ID: 15138 | OA
Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses
F. Geiger, J. Acker, G. Papa, X. Wang, W.E. Arter, K.L. Saar, N.A. Erkamp, R. Qi, J.P.K. Bravo, S. Strauss, G. Krainer, O.R. Burrone, R. Jungmann, T.P. Knowles, H. Engelke, A. Borodavka, The EMBO Journal 40 (2021).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[5]
2021 | Journal Article | IST-REx-ID: 15137 | OA
SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation
J.A. Steens, Y. Zhu, D.W. Taylor, J.P.K. Bravo, S.H.P. Prinsen, C.D. Schoen, B.J.F. Keijser, M. Ossendrijver, L.M. Hofstra, S.J.J. Brouns, A. Shinkai, J. van der Oost, R.H.J. Staals, Nature Communications 12 (2021).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[4]
2021 | Journal Article | IST-REx-ID: 15139 | OA
Structural basis of rotavirus RNA chaperone displacement and RNA annealing
J.P.K. Bravo, K. Bartnik, L. Venditti, J. Acker, E.H. Gail, A. Colyer, C. Davidovich, D.C. Lamb, R. Tuma, A.N. Calabrese, A. Borodavka, Proceedings of the National Academy of Sciences 118 (2021).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[3]
2021 | Journal Article | IST-REx-ID: 15140 | OA
Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication
J.P.K. Bravo, T.L. Dangerfield, D.W. Taylor, K.A. Johnson, Molecular Cell 81 (2021) 1548–1552.e4.
[Preprint] View | DOI | Download Preprint (ext.) | PubMed | Europe PMC
 
[2]
2020 | Journal Article | IST-REx-ID: 15142 | OA
Structural basis for assembly of non-canonical small subunits into type I-C Cascade
R.E. O’Brien, I.C. Santos, D. Wrapp, J.P.K. Bravo, E.A. Schwartz, J.S. Brodbelt, D.W. Taylor, Nature Communications 11 (2020).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[1]
2018 | Journal Article | IST-REx-ID: 15143 | OA
Stability of local secondary structure determines selectivity of viral RNA chaperones
J.P.K. Bravo, A. Borodavka, A. Barth, A.N. Calabrese, P. Mojzes, J.J.B. Cockburn, D.C. Lamb, R. Tuma, Nucleic Acids Research 46 (2018) 7924–7937.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
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23 Publications

Mark all

[23]
2024 | Journal Article | IST-REx-ID: 15372 | OA
Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9
G.N. Hibshman, J.P.K. Bravo, M.M. Hooper, T.L. Dangerfield, H. Zhang, I.J. Finkelstein, K.A. Johnson, D.W. Taylor, Nature Communications 15 (2024).
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
[22]
2024 | Journal Article | IST-REx-ID: 17114 | OA
RNA targeting and cleavage by the type III-Dv CRISPR effector complex
E.A. Schwartz, J.P.K. Bravo, M. Ahsan, L.A. Macias, C.L. McCafferty, T.L. Dangerfield, J.N. Walker, J.S. Brodbelt, G. Palermo, P.C. Fineran, R.D. Fagerlund, D.W. Taylor, Nature Communications 15 (2024).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[21]
2024 | Journal Article | IST-REx-ID: 17113 | OA
Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9
G.N. Hibshman, J.P.K. Bravo, M.M. Hooper, T.L. Dangerfield, H. Zhang, I.J. Finkelstein, K.A. Johnson, D.W. Taylor, Nature Communications 15 (2024).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[20]
2024 | Journal Article | IST-REx-ID: 17111
Lipid droplets as substrates for protein phase separation
A. Kamatar, J.P.K. Bravo, F. Yuan, L. Wang, E.M. Lafer, D.W. Taylor, J.C. Stachowiak, S.H. Parekh, Biophysical Journal (n.d.).
View | DOI | PubMed | Europe PMC
 
[19]
2023 | Journal Article | IST-REx-ID: 15130 | OA
RNA targeting unleashes indiscriminate nuclease activity of CRISPR–Cas12a2
J.P.K. Bravo, T. Hallmark, B. Naegle, C.L. Beisel, R.N. Jackson, D.W. Taylor, Nature 613 (2023) 582–587.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[18]
2023 | Journal Article | IST-REx-ID: 15129 | OA
Structural snapshots of R-loop formation by a type I-C CRISPR Cascade
R.E. O’Brien, J.P.K. Bravo, D. Ramos, G.N. Hibshman, J.T. Wright, D.W. Taylor, Molecular Cell 83 (2023) 746–758.e5.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[17]
2023 | Preprint | IST-REx-ID: 17112 | OA
Type III-B CRISPR-Cas signaling-based cascade of proteolytic cleavages
J.A. Steens, J.P.K. Bravo, C.R.P. Salazar, C. Yildiz, A.M. Amieiro, S. Köstlbacher, S.H.P. Prinsen, C. Patinios, A. Bardis, A. Barendregt, R.A. Scheltema, T.J.G. Ettema, J. van der Oost, D.W. Taylor, R.H.J. Staals, BioRxiv (2023).
[Preprint] View | DOI | Download Preprint (ext.)
 
[16]
2022 | Journal Article | IST-REx-ID: 15144
SuperFi-Cas9 exceeds fidelity, matches speed of original Cas9
J.P.K. Bravo, Genetic Engineering & Biotechnology News 42 (2022) 12.
View | DOI
 
[15]
2022 | Journal Article | IST-REx-ID: 15134 | OA
Structural rearrangements allow nucleic acid discrimination by type I-D Cascade
E.A. Schwartz, T.M. McBride, J.P.K. Bravo, D. Wrapp, P.C. Fineran, R.D. Fagerlund, D.W. Taylor, Nature Communications 13 (2022).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[14]
2022 | Journal Article | IST-REx-ID: 15131 | OA
A single 2′-O-methylation of ribosomal RNA gates assembly of a functional ribosome
J.N. Yelland, J.P.K. Bravo, J.J. Black, D.W. Taylor, A.W. Johnson, Nature Structural & Molecular Biology 30 (2022) 91–98.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[13]
2022 | Journal Article | IST-REx-ID: 15133 | OA
Structural basis for broad anti-phage immunity by DISARM
J.P.K. Bravo, C. Aparicio-Maldonado, F.L. Nobrega, S.J.J. Brouns, D.W. Taylor, Nature Communications 13 (2022).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[12]
2022 | Journal Article | IST-REx-ID: 15132
Constructing next-generation CRISPR–Cas tools from structural blueprints
J.P.K. Bravo, G.N. Hibshman, D.W. Taylor, Current Opinion in Biotechnology 78 (2022).
View | DOI | PubMed | Europe PMC
 
[11]
2022 | Journal Article | IST-REx-ID: 15136 | OA
Structural basis for mismatch surveillance by CRISPR–Cas9
J.P.K. Bravo, M.-S. Liu, G.N. Hibshman, T.L. Dangerfield, K. Jung, R.S. McCool, K.A. Johnson, D.W. Taylor, Nature 603 (2022) 343–347.
[Published Version] View | Files available | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[10]
2022 | Preprint | IST-REx-ID: 17116 | OA
Assembly of multi-subunit fusion proteins into the RNA-targeting type III-D CRISPR-Cas effector complex
E.A. Schwartz, J.P.K. Bravo, L.A. Macias, C.L. McCafferty, T.L. Dangerfield, J.N. Walker, J.S. Brodbelt, P.C. Fineran, R.D. Fagerlund, D.W. Taylor, BioRxiv (n.d.).
[Preprint] View | DOI | Download Preprint (ext.)
 
[9]
2022 | Preprint | IST-REx-ID: 17115 | OA
Modes of inhibition used by phage anti-CRISPRs to evade type I-C Cascade
R.E. O’Brien, J.P.K. Bravo, D. Ramos, G.N. Hibshman, J.T. Wright, D.W. Taylor, BioRxiv (2022).
[Preprint] View | DOI | Download Preprint (ext.)
 
[8]
2022 | Preprint | IST-REx-ID: 17117 | OA
Large-scale structural rearrangements unleash indiscriminate nuclease activity of CRISPR-Cas12a2
J.P.K. Bravo, T. Hallmark, B. Naegle, C.L. Beisel, R.N. Jackson, D.W. Taylor, BioRxiv (2022).
[Preprint] View | DOI | Download Preprint (ext.)
 
[7]
2021 | Journal Article | IST-REx-ID: 15141 | OA
Structure of a type IV CRISPR-Cas ribonucleoprotein complex
Y. Zhou, J.P.K. Bravo, H.N. Taylor, J.A. Steens, R.N. Jackson, R.H.J. Staals, D.W. Taylor, IScience 24 (2021).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[6]
2021 | Journal Article | IST-REx-ID: 15138 | OA
Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses
F. Geiger, J. Acker, G. Papa, X. Wang, W.E. Arter, K.L. Saar, N.A. Erkamp, R. Qi, J.P.K. Bravo, S. Strauss, G. Krainer, O.R. Burrone, R. Jungmann, T.P. Knowles, H. Engelke, A. Borodavka, The EMBO Journal 40 (2021).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[5]
2021 | Journal Article | IST-REx-ID: 15137 | OA
SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation
J.A. Steens, Y. Zhu, D.W. Taylor, J.P.K. Bravo, S.H.P. Prinsen, C.D. Schoen, B.J.F. Keijser, M. Ossendrijver, L.M. Hofstra, S.J.J. Brouns, A. Shinkai, J. van der Oost, R.H.J. Staals, Nature Communications 12 (2021).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[4]
2021 | Journal Article | IST-REx-ID: 15139 | OA
Structural basis of rotavirus RNA chaperone displacement and RNA annealing
J.P.K. Bravo, K. Bartnik, L. Venditti, J. Acker, E.H. Gail, A. Colyer, C. Davidovich, D.C. Lamb, R. Tuma, A.N. Calabrese, A. Borodavka, Proceedings of the National Academy of Sciences 118 (2021).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[3]
2021 | Journal Article | IST-REx-ID: 15140 | OA
Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication
J.P.K. Bravo, T.L. Dangerfield, D.W. Taylor, K.A. Johnson, Molecular Cell 81 (2021) 1548–1552.e4.
[Preprint] View | DOI | Download Preprint (ext.) | PubMed | Europe PMC
 
[2]
2020 | Journal Article | IST-REx-ID: 15142 | OA
Structural basis for assembly of non-canonical small subunits into type I-C Cascade
R.E. O’Brien, I.C. Santos, D. Wrapp, J.P.K. Bravo, E.A. Schwartz, J.S. Brodbelt, D.W. Taylor, Nature Communications 11 (2020).
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[1]
2018 | Journal Article | IST-REx-ID: 15143 | OA
Stability of local secondary structure determines selectivity of viral RNA chaperones
J.P.K. Bravo, A. Borodavka, A. Barth, A.N. Calabrese, P. Mojzes, J.J.B. Cockburn, D.C. Lamb, R. Tuma, Nucleic Acids Research 46 (2018) 7924–7937.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
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    Citation Style: Default

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