Jack Bravo

28 Publications

Mark all

[28]
2025 | Published | Journal Article | IST-REx-ID: 18848 | OA
Ocampo, Rodrigo Fregoso, et al. “DNA Targeting by Compact Cas9d and Its Resurrected Ancestor.” Nature Communications, vol. 16, 457, Springer Nature, 2025, doi:10.1038/s41467-024-55573-4.
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
[27]
2025 | In Press | Journal Article | IST-REx-ID: 20143 | OA | PlanS
Zhang, Zhiying, et al. “Kiwa Is a Membrane-Embedded Defense Supercomplex Activated at Phage Attachment Sites.” Cell, Elsevier, doi:10.1016/j.cell.2025.07.002.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[26]
2024 | Published | Journal Article | IST-REx-ID: 17113 | OA
Hibshman, Grace N., et al. “Unraveling the Mechanisms of PAMless DNA Interrogation by SpRY-Cas9.” Nature Communications, vol. 15, 3663, Springer Nature, 2024, doi:10.1038/s41467-024-47830-3.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[25]
2024 | Published | Journal Article | IST-REx-ID: 17114 | OA
Schwartz, Evan A., et al. “RNA Targeting and Cleavage by the Type III-Dv CRISPR Effector Complex.” Nature Communications, vol. 15, 3324, Springer Nature, 2024, doi:10.1038/s41467-024-47506-y.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[24]
2024 | Published | Journal Article | IST-REx-ID: 18545 | OA
Degtev, Dmitrii, et al. “Engineered PsCas9 Enables Therapeutic Genome Editing in Mouse Liver with Lipid Nanoparticles.” Nature Communications, vol. 15, 9173, Springer Nature, 2024, doi:10.1038/s41467-024-53418-8.
[Published Version] View | Files available | DOI
 
[23]
2024 | Published | Journal Article | IST-REx-ID: 17111
Kamatar, Advika, et al. “Lipid Droplets as Substrates for Protein Phase Separation.” Biophysical Journal, vol. 123, no. 11, Elsevier, 2024, pp. 1494–507, doi:10.1016/j.bpj.2024.03.015.
View | DOI | PubMed | Europe PMC
 
[22]
2024 | Published | Journal Article | IST-REx-ID: 15372 | OA
Hibshman, Grace N., et al. “Unraveling the Mechanisms of PAMless DNA Interrogation by SpRY-Cas9.” Nature Communications, vol. 15, 3663, Springer Nature, 2024, doi:10.1038/s41467-024-47830-3.
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
[21]
2024 | Published | Journal Article | IST-REx-ID: 17442 | OA
Bravo, Jack Peter Kelly, et al. “Plasmid Targeting and Destruction by the DdmDE Bacterial Defence System.” Nature, vol. 630, no. 8018, Springer Nature, 2024, pp. 961–67, doi:10.1038/s41586-024-07515-9.
[Submitted Version] View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
[20]
2024 | Published | Journal Article | IST-REx-ID: 17494 | OA
Bravo, Jack Peter Kelly. “Anti-Plasmid Immunity: A Key to Pathogen Success?” Future Microbiology, vol. 19, no. 15, Taylor & Francis, 2024, pp. 1269–72, doi:10.1080/17460913.2024.2389720.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[19]
2023 | Published | Preprint | IST-REx-ID: 17112 | OA
Steens, Jurre A., et al. “Type III-B CRISPR-Cas Signaling-Based Cascade of Proteolytic Cleavages.” BioRxiv, Cold Spring Harbor Laboratory, 2023, doi:10.1101/2023.06.23.546230.
[Preprint] View | DOI | Download Preprint (ext.)
 
[18]
2023 | Published | Journal Article | IST-REx-ID: 15129 | OA
O’Brien, Roisin E., et al. “Structural Snapshots of R-Loop Formation by a Type I-C CRISPR Cascade.” Molecular Cell, vol. 83, no. 5, Elsevier, 2023, p. 746–758.e5, doi:10.1016/j.molcel.2023.01.024.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[17]
2023 | Published | Journal Article | IST-REx-ID: 15130 | OA
Bravo, Jack Peter Kelly, et al. “RNA Targeting Unleashes Indiscriminate Nuclease Activity of CRISPR–Cas12a2.” Nature, vol. 613, no. 7944, Springer Nature, 2023, pp. 582–87, doi:10.1038/s41586-022-05560-w.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[16]
2022 | Published | Preprint | IST-REx-ID: 17115 | OA
O’Brien, Roisin E., et al. “Modes of Inhibition Used by Phage Anti-CRISPRs to Evade Type I-C Cascade.” BioRxiv, Cold Spring Harbor Laboratory, 2022, doi:10.1101/2022.06.15.496202.
[Preprint] View | DOI | Download Preprint (ext.)
 
[15]
2022 | Submitted | Preprint | IST-REx-ID: 17116 | OA
Schwartz, Evan A., et al. “Assembly of Multi-Subunit Fusion Proteins into the RNA-Targeting Type III-D CRISPR-Cas Effector Complex.” BioRxiv, Cold Spring Harbor Laboratory, doi:10.1101/2022.06.13.496011.
[Preprint] View | DOI | Download Preprint (ext.)
 
[14]
2022 | Published | Preprint | IST-REx-ID: 17117 | OA
Bravo, Jack Peter Kelly, et al. “Large-Scale Structural Rearrangements Unleash Indiscriminate Nuclease Activity of CRISPR-Cas12a2.” BioRxiv, Cold Spring Harbor Laboratory, 2022, doi:10.1101/2022.06.13.495754.
[Preprint] View | DOI | Download Preprint (ext.)
 
[13]
2022 | Published | Journal Article | IST-REx-ID: 15131 | OA
Yelland, James N., et al. “A Single 2′-O-Methylation of Ribosomal RNA Gates Assembly of a Functional Ribosome.” Nature Structural & Molecular Biology, vol. 30, Springer Nature, 2022, pp. 91–98, doi:10.1038/s41594-022-00891-8.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[12]
2022 | Published | Journal Article | IST-REx-ID: 15132
Bravo, Jack Peter Kelly, et al. “Constructing Next-Generation CRISPR–Cas Tools from Structural Blueprints.” Current Opinion in Biotechnology, vol. 78, 102839, Elsevier, 2022, doi:10.1016/j.copbio.2022.102839.
View | DOI | PubMed | Europe PMC
 
[11]
2022 | Published | Journal Article | IST-REx-ID: 15133 | OA
Bravo, Jack Peter Kelly, et al. “Structural Basis for Broad Anti-Phage Immunity by DISARM.” Nature Communications, vol. 13, 2987, Springer Nature, 2022, doi:10.1038/s41467-022-30673-1.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[10]
2022 | Published | Journal Article | IST-REx-ID: 15134 | OA
Schwartz, Evan A., et al. “Structural Rearrangements Allow Nucleic Acid Discrimination by Type I-D Cascade.” Nature Communications, vol. 13, 2829, Springer Nature, 2022, doi:10.1038/s41467-022-30402-8.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[9]
2022 | Published | Journal Article | IST-REx-ID: 15136 | OA
Bravo, Jack Peter Kelly, et al. “Structural Basis for Mismatch Surveillance by CRISPR–Cas9.” Nature, vol. 603, no. 7900, Springer Nature, 2022, pp. 343–47, doi:10.1038/s41586-022-04470-1.
[Published Version] View | Files available | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[8]
2022 | Published | Journal Article | IST-REx-ID: 15144
Bravo, Jack Peter Kelly. “SuperFi-Cas9 Exceeds Fidelity, Matches Speed of Original Cas9.” Genetic Engineering & Biotechnology News, vol. 42, no. 4, Mary Ann Liebert, 2022, p. 12, doi:10.1089/gen.42.04.03.
View | DOI
 
[7]
2021 | Published | Journal Article | IST-REx-ID: 15137 | OA
Steens, Jurre A., et al. “SCOPE Enables Type III CRISPR-Cas Diagnostics Using Flexible Targeting and Stringent CARF Ribonuclease Activation.” Nature Communications, vol. 12, 5033, Springer Nature, 2021, doi:10.1038/s41467-021-25337-5.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[6]
2021 | Published | Journal Article | IST-REx-ID: 15138 | OA
Geiger, Florian, et al. “Liquid–Liquid Phase Separation Underpins the Formation of Replication Factories in Rotaviruses.” The EMBO Journal, vol. 40, no. 21, e107711, Embo Press, 2021, doi:10.15252/embj.2021107711.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[5]
2021 | Published | Journal Article | IST-REx-ID: 15139 | OA
Bravo, Jack Peter Kelly, et al. “Structural Basis of Rotavirus RNA Chaperone Displacement and RNA Annealing.” Proceedings of the National Academy of Sciences, vol. 118, no. 41, e2100198118, Proceedings of the National Academy of Sciences, 2021, doi:10.1073/pnas.2100198118.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[4]
2021 | Published | Journal Article | IST-REx-ID: 15140 | OA
Bravo, Jack Peter Kelly, et al. “Remdesivir Is a Delayed Translocation Inhibitor of SARS-CoV-2 Replication.” Molecular Cell, vol. 81, no. 7, Elsevier, 2021, p. 1548–1552.e4, doi:10.1016/j.molcel.2021.01.035.
[Preprint] View | DOI | Download Preprint (ext.) | PubMed | Europe PMC
 
[3]
2021 | Published | Journal Article | IST-REx-ID: 15141 | OA
Zhou, Yi, et al. “Structure of a Type IV CRISPR-Cas Ribonucleoprotein Complex.” IScience, vol. 24, no. 3, 102201, Elsevier, 2021, doi:10.1016/j.isci.2021.102201.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[2]
2020 | Published | Journal Article | IST-REx-ID: 15142 | OA
O’Brien, Roisin E., et al. “Structural Basis for Assembly of Non-Canonical Small Subunits into Type I-C Cascade.” Nature Communications, vol. 11, 5931, Springer Nature, 2020, doi:10.1038/s41467-020-19785-8.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[1]
2018 | Published | Journal Article | IST-REx-ID: 15143 | OA
Bravo, Jack Peter Kelly, et al. “Stability of Local Secondary Structure Determines Selectivity of Viral RNA Chaperones.” Nucleic Acids Research, vol. 46, no. 15, Oxford University Press, 2018, pp. 7924–37, doi:10.1093/nar/gky394.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
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28 Publications

Mark all

[28]
2025 | Published | Journal Article | IST-REx-ID: 18848 | OA
Ocampo, Rodrigo Fregoso, et al. “DNA Targeting by Compact Cas9d and Its Resurrected Ancestor.” Nature Communications, vol. 16, 457, Springer Nature, 2025, doi:10.1038/s41467-024-55573-4.
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
[27]
2025 | In Press | Journal Article | IST-REx-ID: 20143 | OA | PlanS
Zhang, Zhiying, et al. “Kiwa Is a Membrane-Embedded Defense Supercomplex Activated at Phage Attachment Sites.” Cell, Elsevier, doi:10.1016/j.cell.2025.07.002.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[26]
2024 | Published | Journal Article | IST-REx-ID: 17113 | OA
Hibshman, Grace N., et al. “Unraveling the Mechanisms of PAMless DNA Interrogation by SpRY-Cas9.” Nature Communications, vol. 15, 3663, Springer Nature, 2024, doi:10.1038/s41467-024-47830-3.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[25]
2024 | Published | Journal Article | IST-REx-ID: 17114 | OA
Schwartz, Evan A., et al. “RNA Targeting and Cleavage by the Type III-Dv CRISPR Effector Complex.” Nature Communications, vol. 15, 3324, Springer Nature, 2024, doi:10.1038/s41467-024-47506-y.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[24]
2024 | Published | Journal Article | IST-REx-ID: 18545 | OA
Degtev, Dmitrii, et al. “Engineered PsCas9 Enables Therapeutic Genome Editing in Mouse Liver with Lipid Nanoparticles.” Nature Communications, vol. 15, 9173, Springer Nature, 2024, doi:10.1038/s41467-024-53418-8.
[Published Version] View | Files available | DOI
 
[23]
2024 | Published | Journal Article | IST-REx-ID: 17111
Kamatar, Advika, et al. “Lipid Droplets as Substrates for Protein Phase Separation.” Biophysical Journal, vol. 123, no. 11, Elsevier, 2024, pp. 1494–507, doi:10.1016/j.bpj.2024.03.015.
View | DOI | PubMed | Europe PMC
 
[22]
2024 | Published | Journal Article | IST-REx-ID: 15372 | OA
Hibshman, Grace N., et al. “Unraveling the Mechanisms of PAMless DNA Interrogation by SpRY-Cas9.” Nature Communications, vol. 15, 3663, Springer Nature, 2024, doi:10.1038/s41467-024-47830-3.
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
[21]
2024 | Published | Journal Article | IST-REx-ID: 17442 | OA
Bravo, Jack Peter Kelly, et al. “Plasmid Targeting and Destruction by the DdmDE Bacterial Defence System.” Nature, vol. 630, no. 8018, Springer Nature, 2024, pp. 961–67, doi:10.1038/s41586-024-07515-9.
[Submitted Version] View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
[20]
2024 | Published | Journal Article | IST-REx-ID: 17494 | OA
Bravo, Jack Peter Kelly. “Anti-Plasmid Immunity: A Key to Pathogen Success?” Future Microbiology, vol. 19, no. 15, Taylor & Francis, 2024, pp. 1269–72, doi:10.1080/17460913.2024.2389720.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[19]
2023 | Published | Preprint | IST-REx-ID: 17112 | OA
Steens, Jurre A., et al. “Type III-B CRISPR-Cas Signaling-Based Cascade of Proteolytic Cleavages.” BioRxiv, Cold Spring Harbor Laboratory, 2023, doi:10.1101/2023.06.23.546230.
[Preprint] View | DOI | Download Preprint (ext.)
 
[18]
2023 | Published | Journal Article | IST-REx-ID: 15129 | OA
O’Brien, Roisin E., et al. “Structural Snapshots of R-Loop Formation by a Type I-C CRISPR Cascade.” Molecular Cell, vol. 83, no. 5, Elsevier, 2023, p. 746–758.e5, doi:10.1016/j.molcel.2023.01.024.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[17]
2023 | Published | Journal Article | IST-REx-ID: 15130 | OA
Bravo, Jack Peter Kelly, et al. “RNA Targeting Unleashes Indiscriminate Nuclease Activity of CRISPR–Cas12a2.” Nature, vol. 613, no. 7944, Springer Nature, 2023, pp. 582–87, doi:10.1038/s41586-022-05560-w.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[16]
2022 | Published | Preprint | IST-REx-ID: 17115 | OA
O’Brien, Roisin E., et al. “Modes of Inhibition Used by Phage Anti-CRISPRs to Evade Type I-C Cascade.” BioRxiv, Cold Spring Harbor Laboratory, 2022, doi:10.1101/2022.06.15.496202.
[Preprint] View | DOI | Download Preprint (ext.)
 
[15]
2022 | Submitted | Preprint | IST-REx-ID: 17116 | OA
Schwartz, Evan A., et al. “Assembly of Multi-Subunit Fusion Proteins into the RNA-Targeting Type III-D CRISPR-Cas Effector Complex.” BioRxiv, Cold Spring Harbor Laboratory, doi:10.1101/2022.06.13.496011.
[Preprint] View | DOI | Download Preprint (ext.)
 
[14]
2022 | Published | Preprint | IST-REx-ID: 17117 | OA
Bravo, Jack Peter Kelly, et al. “Large-Scale Structural Rearrangements Unleash Indiscriminate Nuclease Activity of CRISPR-Cas12a2.” BioRxiv, Cold Spring Harbor Laboratory, 2022, doi:10.1101/2022.06.13.495754.
[Preprint] View | DOI | Download Preprint (ext.)
 
[13]
2022 | Published | Journal Article | IST-REx-ID: 15131 | OA
Yelland, James N., et al. “A Single 2′-O-Methylation of Ribosomal RNA Gates Assembly of a Functional Ribosome.” Nature Structural & Molecular Biology, vol. 30, Springer Nature, 2022, pp. 91–98, doi:10.1038/s41594-022-00891-8.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[12]
2022 | Published | Journal Article | IST-REx-ID: 15132
Bravo, Jack Peter Kelly, et al. “Constructing Next-Generation CRISPR–Cas Tools from Structural Blueprints.” Current Opinion in Biotechnology, vol. 78, 102839, Elsevier, 2022, doi:10.1016/j.copbio.2022.102839.
View | DOI | PubMed | Europe PMC
 
[11]
2022 | Published | Journal Article | IST-REx-ID: 15133 | OA
Bravo, Jack Peter Kelly, et al. “Structural Basis for Broad Anti-Phage Immunity by DISARM.” Nature Communications, vol. 13, 2987, Springer Nature, 2022, doi:10.1038/s41467-022-30673-1.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[10]
2022 | Published | Journal Article | IST-REx-ID: 15134 | OA
Schwartz, Evan A., et al. “Structural Rearrangements Allow Nucleic Acid Discrimination by Type I-D Cascade.” Nature Communications, vol. 13, 2829, Springer Nature, 2022, doi:10.1038/s41467-022-30402-8.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[9]
2022 | Published | Journal Article | IST-REx-ID: 15136 | OA
Bravo, Jack Peter Kelly, et al. “Structural Basis for Mismatch Surveillance by CRISPR–Cas9.” Nature, vol. 603, no. 7900, Springer Nature, 2022, pp. 343–47, doi:10.1038/s41586-022-04470-1.
[Published Version] View | Files available | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[8]
2022 | Published | Journal Article | IST-REx-ID: 15144
Bravo, Jack Peter Kelly. “SuperFi-Cas9 Exceeds Fidelity, Matches Speed of Original Cas9.” Genetic Engineering & Biotechnology News, vol. 42, no. 4, Mary Ann Liebert, 2022, p. 12, doi:10.1089/gen.42.04.03.
View | DOI
 
[7]
2021 | Published | Journal Article | IST-REx-ID: 15137 | OA
Steens, Jurre A., et al. “SCOPE Enables Type III CRISPR-Cas Diagnostics Using Flexible Targeting and Stringent CARF Ribonuclease Activation.” Nature Communications, vol. 12, 5033, Springer Nature, 2021, doi:10.1038/s41467-021-25337-5.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[6]
2021 | Published | Journal Article | IST-REx-ID: 15138 | OA
Geiger, Florian, et al. “Liquid–Liquid Phase Separation Underpins the Formation of Replication Factories in Rotaviruses.” The EMBO Journal, vol. 40, no. 21, e107711, Embo Press, 2021, doi:10.15252/embj.2021107711.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[5]
2021 | Published | Journal Article | IST-REx-ID: 15139 | OA
Bravo, Jack Peter Kelly, et al. “Structural Basis of Rotavirus RNA Chaperone Displacement and RNA Annealing.” Proceedings of the National Academy of Sciences, vol. 118, no. 41, e2100198118, Proceedings of the National Academy of Sciences, 2021, doi:10.1073/pnas.2100198118.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[4]
2021 | Published | Journal Article | IST-REx-ID: 15140 | OA
Bravo, Jack Peter Kelly, et al. “Remdesivir Is a Delayed Translocation Inhibitor of SARS-CoV-2 Replication.” Molecular Cell, vol. 81, no. 7, Elsevier, 2021, p. 1548–1552.e4, doi:10.1016/j.molcel.2021.01.035.
[Preprint] View | DOI | Download Preprint (ext.) | PubMed | Europe PMC
 
[3]
2021 | Published | Journal Article | IST-REx-ID: 15141 | OA
Zhou, Yi, et al. “Structure of a Type IV CRISPR-Cas Ribonucleoprotein Complex.” IScience, vol. 24, no. 3, 102201, Elsevier, 2021, doi:10.1016/j.isci.2021.102201.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[2]
2020 | Published | Journal Article | IST-REx-ID: 15142 | OA
O’Brien, Roisin E., et al. “Structural Basis for Assembly of Non-Canonical Small Subunits into Type I-C Cascade.” Nature Communications, vol. 11, 5931, Springer Nature, 2020, doi:10.1038/s41467-020-19785-8.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[1]
2018 | Published | Journal Article | IST-REx-ID: 15143 | OA
Bravo, Jack Peter Kelly, et al. “Stability of Local Secondary Structure Determines Selectivity of Viral RNA Chaperones.” Nucleic Acids Research, vol. 46, no. 15, Oxford University Press, 2018, pp. 7924–37, doi:10.1093/nar/gky394.
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
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Citation Style: MLA

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