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115 Publications


2021 | Journal Article | IST-REx-ID: 9259 | OA
Shape and function of interstitial chemokine CCL21 gradients are independent of heparan sulfates produced by lymphatic endothelium
K. Vaahtomeri, C. Moussion, R. Hauschild, M.K. Sixt, Frontiers in Immunology 12 (2021).
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2021 | Journal Article | IST-REx-ID: 9094 | OA
Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse
A.F. Leithner, L. Altenburger, R. Hauschild, F.P. Assen, K. Rottner, S. TEB, A. Diz-Muñoz, J. Stein, M.K. Sixt, Journal of Cell Biology 220 (2021).
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2021 | Journal Article | IST-REx-ID: 8988 | OA
In vitro reconstitution reveals phosphoinositides as cargo-release factors and activators of the ARF6 GAP ADAP1
C.F. Düllberg, A. Auer, N. Canigova, K. Loibl, M. Loose, PNAS 118 (2021).
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2021 | Journal Article | IST-REx-ID: 9294 | OA
Engaging the front wheels to drive through fibrous terrain
F.R. Gärtner, M.K. Sixt, Developmental Cell 56 (2021) 723–725.
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2021 | Journal Article | IST-REx-ID: 9822 | OA
Sequential and switchable patterning for studying cellular processes under spatiotemporal control
T. Zisis, J. Schwarz, M. Balles, M. Kretschmer, M. Nemethova, R.P. Chait, R. Hauschild, J. Lange, C.C. Guet, M.K. Sixt, S. Zahler, ACS Applied Materials and Interfaces 13 (2021) 35545–35560.
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2021 | Journal Article | IST-REx-ID: 9429 | OA
Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development
J. Morandell, L.A. Schwarz, B. Basilico, S. Tasciyan, G.A. Dimchev, A. Nicolas, C.M. Sommer, C. Kreuzinger, C. Dotter, L. Knaus, Z. Dobler, E. Cacci, F.K. Schur, J.G. Danzl, G. Novarino, Nature Communications 12 (2021).
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2021 | Thesis | IST-REx-ID: 10307 | OA
Pathogenic Escherichia coli hijack the host immune response
K. Tomasek, Pathogenic Escherichia Coli Hijack the Host Immune Response, IST Austria, 2021.
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2021 | Preprint | IST-REx-ID: 10316 | OA
Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14
K. Tomasek, A.F. Leithner, I. Glatzová, M.S. Lukesch, C.C. Guet, M.K. Sixt, BioRxiv (n.d.).
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2020 | Journal Article | IST-REx-ID: 7875 | OA
Microtubules control cellular shape and coherence in amoeboid migrating cells
A. Kopf, J. Renkawitz, R. Hauschild, I. Girkontaite, K. Tedford, J. Merrin, O. Thorn-Seshold, D. Trauner, H. Häcker, K.D. Fischer, E. Kiermaier, M.K. Sixt, The Journal of Cell Biology 219 (2020).
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2020 | Journal Article | IST-REx-ID: 7876 | OA
T cells: Bridge-and-channel commute to the white pulp
M.K. Sixt, T. Lämmermann, Immunity 52 (2020) 721–723.
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2020 | Journal Article | IST-REx-ID: 7909 | OA
Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion
J. Damiano-Guercio, L. Kurzawa, J. Müller, G.A. Dimchev, M. Schaks, M. Nemethova, T. Pokrant, S. Brühmann, J. Linkner, L. Blanchoin, M.K. Sixt, K. Rottner, J. Faix, ELife 9 (2020).
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2020 | Journal Article | IST-REx-ID: 8132
The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity
Salzer E, Zoghi S, Kiss MG, Kage F, Rashkova C, Stahnke S, Haimel M, Platzer R, Caldera M, Ardy RC, Hoeger B, Block J, Medgyesi D, Sin C, Shahkarami S, Kain R, Ziaee V, Hammerl P, Bock C, Menche J, Dupré L, Huppa JB, Sixt MK, Lomakin A, Rottner K, Binder CJ, Stradal TEB, Rezaei N, Boztug K. 2020. The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity. Science Immunology. 5(49), eabc3979.
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2020 | Journal Article | IST-REx-ID: 8142 | OA
Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage
J.C. Montesinos López, A. Abuzeineh, A. Kopf, A. Juanes Garcia, K. Ötvös, J. Petrášek, M.K. Sixt, E. Benková, The Embo Journal 39 (2020).
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2020 | Journal Article | IST-REx-ID: 7234 | OA
Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes
P. Obeidy, L.A. Ju, S.H. Oehlers, N.S. Zulkhernain, Q. Lee, J.L. Galeano Niño, R.Y.Q. Kwan, S. Tikoo, L.L. Cavanagh, P. Mrass, A.J.L. Cook, S.P. Jackson, M. Biro, B. Roediger, M.K. Sixt, W. Weninger, Immunology and Cell Biology 98 (2020) 93–113.
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2020 | Journal Article | IST-REx-ID: 7623 | OA
Modeling adhesion-independent cell migration
G. Jankowiak, D. Peurichard, A. REVERSAT, C. Schmeiser, M.K. Sixt, Mathematical Models and Methods in Applied Sciences 30 (2020) 513–537.
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2020 | Journal Article | IST-REx-ID: 8787 | OA
Vascular surveillance by haptotactic blood platelets in inflammation and infection
Nicolai L, Schiefelbein K, Lipsky S, Leunig A, Hoffknecht M, Pekayvaz K, Raude B, Marx C, Ehrlich A, Pircher J, Zhang Z, Saleh I, Marel A-K, Löf A, Petzold T, Lorenz M, Stark K, Pick R, Rosenberger G, Weckbach L, Uhl B, Xia S, Reichel CA, Walzog B, Schulz C, Zheden V, Bender M, Li R, Massberg S, Gärtner FR. 2020. Vascular surveillance by haptotactic blood platelets in inflammation and infection. Nature Communications. 11, 5778.
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2020 | Journal Article | IST-REx-ID: 7885
Cellular locomotion using environmental topography
A. REVERSAT, F.R. Gärtner, J. Merrin, J.A. Stopp, S. Tasciyan, J.L. Aguilera Servin, I. de Vries, R. Hauschild, M. Hons, M. Piel, A. Callan-Jones, R. Voituriez, M.K. Sixt, Nature 582 (2020) 582–585.
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2020 | Journal Article | IST-REx-ID: 8190 | OA
Zena Werb (1945-2020): Cell biology in context
M.K. Sixt, A. Huttenlocher, The Journal of Cell Biology 219 (2020).
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2019 | Journal Article | IST-REx-ID: 6979
Gut homeostasis: Active migration of intestinal epithelial cells in tissue renewal
A. Kopf, M.K. Sixt, Current Biology 29 (2019) R1091–R1093.
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2019 | Journal Article | IST-REx-ID: 6988
Platelets in host defense: Experimental and clinical insights
L. Nicolai, F.R. Gärtner, S. Massberg, Trends in Immunology 40 (2019) 922–938.
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2019 | Journal Article | IST-REx-ID: 7009
Mechanisms of 3D cell migration
K. Yamada, M.K. Sixt, Nature Reviews Molecular Cell Biology 20 (2019) 738–752.
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2019 | Journal Article | IST-REx-ID: 7105 | OA
Persistent and polarized global actin flow is essential for directionality during cell migration
L. Yolland, M. Burki, S. Marcotti, A. Luchici, F.N. Kenny, J.R. Davis, E. Serna-Morales, J. Müller, M.K. Sixt, A. Davidson, W. Wood, L.J. Schumacher, R.G. Endres, M. Miodownik, B.M. Stramer, Nature Cell Biology 21 (2019) 1370–1381.
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2019 | Journal Article | IST-REx-ID: 7404 | OA
Transient localization of the Arp2/3 complex initiates neuronal dendrite branching in vivo
T. Stürner, A. Tatarnikova, J. Müller, B. Schaffran, H. Cuntz, Y. Zhang, M. Nemethova, S. Bogdan, V. Small, G. Tavosanis, Development 146 (2019).
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2019 | Journal Article | IST-REx-ID: 7420 | OA
GGA2 and RAB13 promote activity-dependent β1-integrin recycling
P. Sahgal, J.H. Alanko, J. Icha, I. Paatero, H. Hamidi, A. Arjonen, M. Pietilä, A. Rokka, J. Ivaska, Journal of Cell Science 132 (2019).
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2019 | Journal Article | IST-REx-ID: 6824
Patrolling the vascular borders: Platelets in immunity to infection and cancer
F.R. Gärtner, S. Massberg, Nature Reviews Immunology 19 (2019) 747–760.
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2019 | Thesis | IST-REx-ID: 6891 | OA
The implication of cytoskeletal dynamics on leukocyte migration
A. Kopf, The Implication of Cytoskeletal Dynamics on Leukocyte Migration, IST Austria, 2019.
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2019 | Journal Article | IST-REx-ID: 6328 | OA
Nuclear positioning facilitates amoeboid migration along the path of least resistance
J. Renkawitz, A. Kopf, J.A. Stopp, I. de Vries, M.K. Driscoll, J. Merrin, R. Hauschild, E.S. Welf, G. Danuser, R. Fiolka, M.K. Sixt, Nature 568 (2019) 546–550.
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2019 | Journal Article | IST-REx-ID: 6877
The neural crest pitches in to remove apoptotic debris
A. Kopf, M.K. Sixt, Cell 179 (2019) 51–53.
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2019 | Thesis | IST-REx-ID: 6947 | OA
Lymph node mechanics: Deciphering the interplay between stroma contractility, morphology and lymphocyte trafficking
F.P. Assen, Lymph Node Mechanics: Deciphering the Interplay between Stroma Contractility, Morphology and Lymphocyte Trafficking, IST Austria, 2019.
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2018 | Journal Article | IST-REx-ID: 308 | OA
Drosophila TNF modulates tissue tension in the embryo to facilitate macrophage invasive migration
A. Ratheesh, J. Biebl, M. Smutny, J. Veselá, E. Papusheva, G. Krens, W. Kaufmann, A. György, A.M. Casano, D.E. Siekhaus, Developmental Cell 45 (2018) 331–346.
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2018 | Journal Article | IST-REx-ID: 318 | OA
A fat lot of good for wound healing
A.M. Casano, M.K. Sixt, Developmental Cell 44 (2018) 405–406.
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2018 | Journal Article | IST-REx-ID: 5672 | OA
IgM's exit route
A. REVERSAT, M.K. Sixt, Journal of Experimental Medicine 215 (2018) 2959–2961.
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2018 | Journal Article | IST-REx-ID: 5858 | OA
Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data
S. Hross, F.J. Theis, M.K. Sixt, J. Hasenauer, Journal of the Royal Society Interface 15 (2018).
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2018 | Journal Article | IST-REx-ID: 5861 | OA
The cell sets the tone
J.H. Alanko, M.K. Sixt, ELife 7 (2018).
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2018 | Journal Article | IST-REx-ID: 5984 | OA
Optical functionalization of human class A orphan G-protein-coupled receptors
M. Morri, I. Sanchez-Romero, A.-M. Tichy, S. Kainrath, E.J. Gerrard, P. Hirschfeld, J. Schwarz, H.L. Janovjak, Nature Communications 9 (2018).
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2018 | Journal Article | IST-REx-ID: 5992 | OA
On the relation between filament density, force generation, and protrusion rate in mesenchymal cell motility
S. Dolati, F. Kage, J. Mueller, M. Müsken, M. Kirchner, G. Dittmar, M.K. Sixt, K. Rottner, M. Falcke, Molecular Biology of the Cell 29 (2018) 2674–2686.
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2018 | Journal Article | IST-REx-ID: 6354 | OA
Platelet migration and bacterial trapping assay under flow
S. Fan, M. Lorenz, S. Massberg, F.R. Gärtner, Bio-Protocol 8 (2018).
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2018 | Journal Article | IST-REx-ID: 6497 | OA
The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+T cells
F. Moalli, X. Ficht, P. Germann, M. Vladymyrov, B. Stolp, I. de Vries, R. Lyck, J. Balmer, A. Fiocchi, M. Kreutzfeldt, D. Merkler, M. Iannacone, A. Ariga, M.H. Stoffel, J. Sharpe, M. Bähler, M.K. Sixt, A. Diz-Muñoz, J.V. Stein, The Journal of Experimental Medicine 2015 (2018) 1869–1890.
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2018 | Book Chapter | IST-REx-ID: 153
Micro-engineered “pillar forests” to study cell migration in complex but controlled 3D environments
J. Renkawitz, A. REVERSAT, A.F. Leithner, J. Merrin, M.K. Sixt, in:, Methods in Cell Biology, Academic Press, 2018, pp. 79–91.
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2018 | Journal Article | IST-REx-ID: 275 | OA
Lymphatic exosomes promote dendritic cell migration along guidance cues
M. Brown, L. Johnson, D. Leone, P. Májek, K. Vaahtomeri, D. Senfter, N. Bukosza, H. Schachner, G. Asfour, B. Langer, R. Hauschild, K. Parapatics, Y. Hong, K. Bennett, R. Kain, M. Detmar, M.K. Sixt, D. Jackson, D. Kerjaschki, Journal of Cell Biology 217 (2018) 2205–2221.
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2018 | Journal Article | IST-REx-ID: 276 | OA
Nano-scale microfluidics to study 3D chemotaxis at the single cell level
C. Frick, P. Dettinger, J. Renkawitz, A. Jauch, C. Berger, M. Recher, T. Schroeder, M. Mehling, PLoS One 13 (2018).
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2018 | Journal Article | IST-REx-ID: 437 | OA
Fast and efficient genetic engineering of hematopoietic precursor cells for the study of dendritic cell migration
A.F. Leithner, J. Renkawitz, I. de Vries, R. Hauschild, H. Haecker, M.K. Sixt, European Journal of Immunology 48 (2018) 1074–1077.
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2018 | Journal Article | IST-REx-ID: 15 | OA
Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells
M. Hons, A. Kopf, R. Hauschild, A.F. Leithner, F.R. Gärtner, J. Abe, J. Renkawitz, J. Stein, M.K. Sixt, Nature Immunology 19 (2018) 606–616.
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2018 | Journal Article | IST-REx-ID: 402 | OA
Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice
M. Brown, F.P. Assen, A.F. Leithner, J. Abe, H. Schachner, G. Asfour, Z. Bagó Horváth, J. Stein, P. Uhrin, M.K. Sixt, D. Kerjaschki, Science 359 (2018) 1408–1411.
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2018 | Thesis | IST-REx-ID: 323 | OA
Branched actin networks in dendritic cell biology
A.F. Leithner, Branched Actin Networks in Dendritic Cell Biology, IST Austria, 2018.
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2017 | Research Data | IST-REx-ID: 5567 | OA
Immunological synapse DC-Tcells
A.F. Leithner, (2017).
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2017 | Journal Article | IST-REx-ID: 569 | OA
Cytokinesis in vertebrate cells initiates by contraction of an equatorial actomyosin network composed of randomly oriented filaments
F. Spira, S. Cuylen Haering, S. Mehta, M. Samwer, A. REVERSAT, A. Verma, R. Oldenbourg, M.K. Sixt, D. Gerlich, ELife 6 (2017).
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2017 | Journal Article | IST-REx-ID: 571
Migrating platelets are mechano scavengers that collect and bundle bacteria
Gärtner FR, Ahmad Z, Rosenberger G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Ishikawa Ankerhold H, Hennel R, Benechet A, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Böttcher R, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos Y Schnitzler M, Pincus Z, Iannacone M, Haas R, Wanner G, Lauber K, Sixt MK, Massberg S. 2017. Migrating platelets are mechano scavengers that collect and bundle bacteria. Cell Press. 171(6), 1368–1382.
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2017 | Journal Article | IST-REx-ID: 727
Load adaptation of lamellipodial actin networks
J. Mueller, G. Szep, M. Nemethova, I. de Vries, A. Lieber, C. Winkler, K. Kruse, J. Small, C. Schmeiser, K. Keren, R. Hauschild, M.K. Sixt, Cell 171 (2017) 188–200.
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2017 | Journal Article | IST-REx-ID: 1161
Cell migration: Making the waves
J. Müller, M.K. Sixt, Current Biology 27 (2017) R24–R25.
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