Martin Hetzer

Hetzer Group

79 Publications

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[79]
2024 | Journal Article | IST-REx-ID: 15316
Zocher S, Mccloskey A, Karasinsky A, et al. Lifelong persistence of nuclear RNAs in the mouse brain. Science. 2024;384(6691):53-59. doi:10.1126/science.adf3481
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[78]
2023 | Journal Article | IST-REx-ID: 12880 | OA
Kaneshiro JM, Capitanio JS, Hetzer M. Lamin B1 overexpression alters chromatin organization and gene expression. Nucleus. 2023;14(1). doi:10.1080/19491034.2023.2202548
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[77]
2023 | Journal Article | IST-REx-ID: 14315 | OA
Cho UH, Hetzer M. Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress. eLife. 2023;12. doi:10.7554/eLife.89066
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[76]
2022 | Journal Article | IST-REx-ID: 11051
Liu J, Hetzer M. Nuclear pore complex maintenance and implications for age-related diseases. Trends in Cell Biology. 2022;32(3):P216-227. doi:10.1016/j.tcb.2021.10.001
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[75]
2021 | Journal Article | IST-REx-ID: 11053 | OA
Shadel GS, Adams PD, Berggren WT, et al. The San Diego Nathan Shock Center: Tackling the heterogeneity of aging. GeroScience. 2021;43(5):2139-2148. doi:10.1007/s11357-021-00426-x
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[74]
2021 | Journal Article | IST-REx-ID: 11052
Krishna S, Arrojo e Drigo R, Capitanio JS, Ramachandra R, Ellisman M, Hetzer M. Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain. Developmental Cell. 2021;56(21):P2952-2965.e9. doi:10.1016/j.devcel.2021.10.008
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[73]
2020 | Journal Article | IST-REx-ID: 11056 | OA
Bersini S, Arrojo e Drigo R, Huang L, Shokhirev MN, Hetzer M. Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease. Advanced Biosystems. 2020;4(5). doi:10.1002/adbi.202000044
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[72]
2020 | Journal Article | IST-REx-ID: 11055 | OA
Bersini S, Schulte R, Huang L, Tsai H, Hetzer M. Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. eLife. 2020;9. doi:10.7554/elife.54383
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[71]
2020 | Journal Article | IST-REx-ID: 11054 | OA
Cho UH, Hetzer M. Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging. Neuron. 2020;106(6):899-911. doi:10.1016/j.neuron.2020.05.031
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[70]
2020 | Journal Article | IST-REx-ID: 11057 | OA
Kang H, Shokhirev MN, Xu Z, Chandran S, Dixon JR, Hetzer M. Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation. Genes & Development. 2020;34(13-14):913-930. doi:10.1101/gad.335794.119
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[69]
2020 | Journal Article | IST-REx-ID: 11058 | OA
Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer M. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life Science Alliance. 2020;3(1). doi:10.26508/lsa.201900623
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
[68]
2019 | Journal Article | IST-REx-ID: 11061 | OA
Toyama BH, Arrojo e Drigo R, Lev-Ram V, et al. Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells. Journal of Cell Biology. 2019;218(2):433-444. doi:10.1083/jcb.201809123
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[67]
2019 | Journal Article | IST-REx-ID: 11062 | OA
Arrojo e Drigo R, Lev-Ram V, Tyagi S, et al. Age mosaicism across multiple scales in adult tissues. Cell Metabolism. 2019;30(2):343-351.e3. doi:10.1016/j.cmet.2019.05.010
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[66]
2019 | Journal Article | IST-REx-ID: 11059
Buchwalter A, Kaneshiro JM, Hetzer M. Coaching from the sidelines: The nuclear periphery in genome regulation. Nature Reviews Genetics. 2019;20(1):39-50. doi:10.1038/s41576-018-0063-5
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[65]
2019 | Journal Article | IST-REx-ID: 11060 | OA
Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. eLife. 2019;8. doi:10.7554/elife.49796
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[64]
2019 | Research Data Reference | IST-REx-ID: 13079 | OA
Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. Data from: Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. 2019. doi:10.5061/DRYAD.N0R525H
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[63]
2018 | Journal Article | IST-REx-ID: 11063 | OA
McCloskey A, Ibarra A, Hetzer M. Tpr regulates the total number of nuclear pore complexes per cell nucleus. Genes & Development. 2018;32(19-20):1321-1331. doi:10.1101/gad.315523.118
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[62]
2018 | Journal Article | IST-REx-ID: 11064 | OA
Fleischer JG, Schulte R, Tsai HH, et al. Predicting age from the transcriptome of human dermal fibroblasts. Genome Biology. 2018;19. doi:10.1186/s13059-018-1599-6
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[61]
2017 | Journal Article | IST-REx-ID: 11066 | OA
Franks TM, McCloskey A, Shokhirev MN, Benner C, Rathore A, Hetzer M. Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. Genes & Development. 2017;31(22):2222-2234. doi:10.1101/gad.306753.117
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[60]
2017 | Journal Article | IST-REx-ID: 11067 | OA
Toda T, Hsu JY, Linker SB, et al. Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. Cell Stem Cell. 2017;21(5):618-634.e7. doi:10.1016/j.stem.2017.08.012
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[59]
2017 | Journal Article | IST-REx-ID: 11065 | OA
Buchwalter A, Hetzer M. Nucleolar expansion and elevated protein translation in premature aging. Nature Communications. 2017;8. doi:10.1038/s41467-017-00322-z
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[58]
2016 | Journal Article | IST-REx-ID: 11072 | OA
van de Ven RAH, de Groot JS, Park D, et al. p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis. Nature Communications. 2016;7. doi:10.1038/ncomms13874
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[57]
2016 | Journal Article | IST-REx-ID: 11071 | OA
Franks TM, Benner C, Narvaiza I, et al. Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes & Development. 2016;30(10):1155-1171. doi:10.1101/gad.280941.116
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[56]
2016 | Journal Article | IST-REx-ID: 11069 | OA
Hatch EM, Hetzer M. Nuclear envelope rupture is induced by actin-based nucleus confinement. Journal of Cell Biology. 2016;215(1):27-36. doi:10.1083/jcb.201603053
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[55]
2016 | Journal Article | IST-REx-ID: 11070 | OA
Ibarra A, Benner C, Tyagi S, Cool J, Hetzer M. Nucleoporin-mediated regulation of cell identity genes. Genes & Development. 2016;30(20):2253-2258. doi:10.1101/gad.287417.116
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[54]
2015 | Journal Article | IST-REx-ID: 11079 | OA
Mertens J, Paquola ACM, Ku M, et al. Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects. Cell Stem Cell. 2015;17(6):705-718. doi:10.1016/j.stem.2015.09.001
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[53]
2015 | Journal Article | IST-REx-ID: 11077 | OA
Jacinto FV, Benner C, Hetzer M. The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes & Development. 2015;29(12):1224-1238. doi:10.1101/gad.260919.115
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[52]
2015 | Journal Article | IST-REx-ID: 11078 | OA
Ori A, Toyama BH, Harris MS, et al. Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats. Cell Systems. 2015;1(3):P224-237. doi:10.1016/j.cels.2015.08.012
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[51]
2015 | Journal Article | IST-REx-ID: 11075
Gomez-Cavazos JS, Hetzer M. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. Journal of Cell Biology. 2015;208(6):671-681. doi:10.1083/jcb.201410047
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[50]
2015 | Journal Article | IST-REx-ID: 11076 | OA
Ibarra A, Hetzer M. Nuclear pore proteins and the control of genome functions. Genes & Development. 2015;29(4):337-349. doi:10.1101/gad.256495.114
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[49]
2015 | Journal Article | IST-REx-ID: 11073 | OA
Hatch EM, Hetzer M. Linking micronuclei to chromosome fragmentation. Cell. 2015;161(7):1502-1504. doi:10.1016/j.cell.2015.06.005
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[48]
2015 | Journal Article | IST-REx-ID: 11074 | OA
Hatch EM, Hetzer M. Chromothripsis. Current Biology. 2015;25(10):PR397-R399. doi:10.1016/j.cub.2015.02.033
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[47]
2014 | Journal Article | IST-REx-ID: 11080 | OA
Buchwalter A, Hetzer M. Nuclear pores set the speed limit for mitosis. Cell. 2014;156(5):868-869. doi:10.1016/j.cell.2014.02.004
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[46]
2014 | Journal Article | IST-REx-ID: 11082 | OA
Buchwalter AL, Liang Y, Hetzer M. Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Molecular Biology of the Cell. 2014;25(16):2472-2484. doi:10.1091/mbc.e14-04-0865
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[45]
2014 | Journal Article | IST-REx-ID: 11081 | OA
Hatch E, Hetzer M. Breaching the nuclear envelope in development and disease. Journal of Cell Biology. 2014;205(2):133-141. doi:10.1083/jcb.201402003
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[44]
2013 | Journal Article | IST-REx-ID: 11086 | OA
Liang Y, Franks TM, Marchetto MC, Gage FH, Hetzer M. Dynamic association of NUP98 with the human genome. PLoS Genetics. 2013;9(2). doi:10.1371/journal.pgen.1003308
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[43]
2013 | Journal Article | IST-REx-ID: 11087 | OA
Toyama BH, Savas JN, Park SK, et al. Identification of long-lived proteins reveals exceptional stability of essential cellular structures. Cell. 2013;154(5):971-982. doi:10.1016/j.cell.2013.07.037
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[42]
2013 | Journal Article | IST-REx-ID: 11085 | OA
Hatch EM, Fischer AH, Deerinck TJ, Hetzer M. Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell. 2013;154(1):47-60. doi:10.1016/j.cell.2013.06.007
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[41]
2013 | Journal Article | IST-REx-ID: 11088 | OA
Regner BM, Vučinić D, Domnisoru C, et al. Anomalous diffusion of single particles in cytoplasm. Biophysical Journal. 2013;104(8):1652-1660. doi:10.1016/j.bpj.2013.01.049
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[40]
2013 | Journal Article | IST-REx-ID: 11083
Franks TM, Hetzer M. The role of Nup98 in transcription regulation in healthy and diseased cells. Trends in Cell Biology. 2013;23(3):112-117. doi:10.1016/j.tcb.2012.10.013
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[39]
2013 | Journal Article | IST-REx-ID: 11084
Toyama BH, Hetzer M. Protein homeostasis: Live long, won’t prosper. Nature Reviews Molecular Cell Biology. 2013;14:55-61. doi:10.1038/nrm3496
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[38]
2012 | Journal Article | IST-REx-ID: 11089
Gomez-Cavazos JS, Hetzer M. Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins. Current Opinion in Cell Biology. 2012;24(6):775-783. doi:10.1016/j.ceb.2012.08.008
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[37]
2012 | Journal Article | IST-REx-ID: 11091
Vargas JD, Hatch EM, Anderson DJ, Hetzer M. Transient nuclear envelope rupturing during interphase in human cancer cells. Nucleus. 2012;3(1):88-100. doi:10.4161/nucl.18954
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[36]
2012 | Journal Article | IST-REx-ID: 11093 | OA
D’Angelo MA, Gomez-Cavazos JS, Mei A, Lackner DH, Hetzer M. A change in nuclear pore complex composition regulates cell differentiation. Developmental Cell. 2012;22(2):446-458. doi:10.1016/j.devcel.2011.11.021
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[35]
2012 | Journal Article | IST-REx-ID: 11092
Savas JN, Toyama BH, Xu T, Yates JR, Hetzer M. Extremely long-lived nuclear pore proteins in the rat brain. Science. 2012;335(6071):942-942. doi:10.1126/science.1217421
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[34]
2012 | Journal Article | IST-REx-ID: 11090 | OA
Hatch EM, Hetzer M. RNP export by nuclear envelope budding. Cell. 2012;149(4):733-735. doi:10.1016/j.cell.2012.04.018
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[33]
2011 | Journal Article | IST-REx-ID: 11094 | OA
Talamas JA, Hetzer M. POM121 and Sun1 play a role in early steps of interphase NPC assembly. Journal of Cell Biology. 2011;194(1):27-37. doi:10.1083/jcb.201012154
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[32]
2011 | Journal Article | IST-REx-ID: 11096
Liang Y, Hetzer M. Functional interactions between nucleoporins and chromatin. Current Opinion in Cell Biology. 2011;23(1):65-70. doi:10.1016/j.ceb.2010.09.008
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[31]
2011 | Journal Article | IST-REx-ID: 11095
Hetzer M, Cavalli G. Editorial overview. Current Opinion in Cell Biology. 2011;23(3):255-257. doi:10.1016/j.ceb.2011.04.013
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[30]
2011 | Journal Article | IST-REx-ID: 11100
Capelson M, Doucet C, Hetzer M. Nuclear pore complexes: Guardians of the nuclear genome. Cold Spring Harbor Symposia on Quantitative Biology. 2011;75:585-597. doi:10.1101/sqb.2010.75.059
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[29]
2010 | Journal Article | IST-REx-ID: 11097
Hetzer M. The nuclear envelope. Cold Spring Harbor Perspectives in Biology. 2010;2(3):a000539-a000539. doi:10.1101/cshperspect.a000539
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[28]
2010 | Journal Article | IST-REx-ID: 11099
Doucet CM, Hetzer M. Nuclear pore biogenesis into an intact nuclear envelope. Chromosoma. 2010;119:469-477. doi:10.1007/s00412-010-0289-2
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[27]
2010 | Journal Article | IST-REx-ID: 11102 | OA
Capelson M, Liang Y, Schulte R, Mair W, Wagner U, Hetzer M. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Cell. 2010;140(3):372-383. doi:10.1016/j.cell.2009.12.054
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[26]
2010 | Journal Article | IST-REx-ID: 11101 | OA
Doucet CM, Talamas JA, Hetzer M. Cell cycle-dependent differences in nuclear pore complex assembly in metazoa. Cell. 2010;141(6):1030-1041. doi:10.1016/j.cell.2010.04.036
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[25]
2010 | Journal Article | IST-REx-ID: 11098 | OA
Hetzer M. The role of the nuclear pore complex in aging of post-mitotic cells. Aging. 2010;2(2):74-75. doi:10.18632/aging.100125
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[24]
2009 | Journal Article | IST-REx-ID: 11103 | OA
Hetzer M, Wente SR. Border control at the nucleus: Biogenesis and organization of the nuclear membrane and pore complexes. Developmental Cell. 2009;17(5):606-616. doi:10.1016/j.devcel.2009.10.007
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[23]
2009 | Journal Article | IST-REx-ID: 11106 | OA
Anderson DJ, Vargas JD, Hsiao JP, Hetzer M. Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo. Journal of Cell Biology. 2009;186(2):183-191. doi:10.1083/jcb.200901106
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[22]
2009 | Journal Article | IST-REx-ID: 11107 | OA
Dawson TR, Lazarus MD, Hetzer M, Wente SR. ER membrane–bending proteins are necessary for de novo nuclear pore formation. Journal of Cell Biology. 2009;184(5):659-675. doi:10.1083/jcb.200806174
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[21]
2009 | Journal Article | IST-REx-ID: 11108 | OA
D’Angelo MA, Raices M, Panowski SH, Hetzer M. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell. 2009;136(2):284-295. doi:10.1016/j.cell.2008.11.037
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[20]
2009 | Journal Article | IST-REx-ID: 11105 | OA
Capelson M, Hetzer M. The role of nuclear pores in gene regulation, development and disease. EMBO reports. 2009;10(7):697-705. doi:10.1038/embor.2009.147
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[19]
2008 | Journal Article | IST-REx-ID: 11111
Anderson DJ, Hetzer M. Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation. Journal of Cell Biology. 2008;182(5):911-924. doi:10.1083/jcb.200805140
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[18]
2008 | Journal Article | IST-REx-ID: 11110
D’Angelo MA, Hetzer M. Structure, dynamics and function of nuclear pore complexes. Trends in Cell Biology. 2008;18(10):456-466. doi:10.1016/j.tcb.2008.07.009
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[17]
2008 | Journal Article | IST-REx-ID: 11109
Kutay U, Hetzer M. Reorganization of the nuclear envelope during open mitosis. Current Opinion in Cell Biology. 2008;20(6):669-677. doi:10.1016/j.ceb.2008.09.010
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[16]
2008 | Journal Article | IST-REx-ID: 11112
Anderson DJ, Hetzer M. The life cycle of the metazoan nuclear envelope. Current Opinion in Cell Biology. 2008;20(4):386-392. doi:10.1016/j.ceb.2008.03.016
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[15]
2008 | Journal Article | IST-REx-ID: 11113 | OA
Anderson DJ, Hetzer M. Shaping the endoplasmic reticulum into the nuclear envelope. Journal of Cell Science. 2008;121(2):137-142. doi:10.1242/jcs.005777
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[14]
2008 | Journal Article | IST-REx-ID: 11114 | OA
Schulte R, Talamas J, Doucet C, Hetzer M. Single bead affinity detection (SINBAD) for the analysis of protein-protein interactions. PLoS ONE. 2008;3(4). doi:10.1371/journal.pone.0002061
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[13]
2007 | Journal Article | IST-REx-ID: 11116 | OA
Franz C, Walczak R, Yavuz S, et al. MEL‐28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. EMBO reports. 2007;8(2):165-172. doi:10.1038/sj.embor.7400889
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[12]
2007 | Journal Article | IST-REx-ID: 11115
Anderson DJ, Hetzer M. Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum. Nature Cell Biology. 2007;9(10):1160-1166. doi:10.1038/ncb1636
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[11]
2006 | Book Chapter | IST-REx-ID: 11119
Harris JR, Almouzni G, Kirschner D, Dimitrova D, Nickerson JA, Underwood J, Wagner S, Korbei B, Foisner R, Walther TC, Hetzer M, Peters R, Walev I, de Kroon AIPM, Staffhorst RWHM, de Kruijff B, Burger KNJ, Netto LES, Bertrand E, Alimonti JB, Greenberg AH, Xiao J, Pradhan A, Liu Y, Paiement J, Young R, Goñi FM, Villar A-V, Contreras F-X, Alonso A, Peter BJ, Mills IG, Higgins MK, Brown WJ, Chambers K, Doody A, Cheng CY, Mruk DD, Yang C, Kirchhoff H, Haase W, Boggasch S, Paulsen H, Benesova J, Liffers S-T, Rögner M, Gao Y, Sztul E, Thiemann M, Fahimi HD, Gniadecki R, Gajkowska B, Bane SL, Hess JF, Voss JC, Fitzgerald PG, Hisanaga S, Sasaki T, Uéda K, Town T, Tan J, Milton NGN, Chi R, Keller TCS, Kriajevska M, Bronstein I, Lukanidin E, Holmes DF, Kadler KE. 2006.In Vitro Techniques. In: Cell Biology Protocols. , 201–378.
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[10]
2006 | Journal Article | IST-REx-ID: 11117
D’Angelo MA, Hetzer M. The role of the nuclear envelope in cellular organization. Cellular and Molecular Life Sciences. 2006;63(3):316-332. doi:10.1007/s00018-005-5361-3
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[9]
2006 | Journal Article | IST-REx-ID: 11118
D’Angelo MA, Anderson DJ, Richard E, Hetzer M. Nuclear pores form de novo from both sides of the nuclear envelope. Science. 2006;312(5772):440-443. doi:10.1126/science.1124196
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[8]
2005 | Journal Article | IST-REx-ID: 11120
Hetzer M, Walther TC, Mattaj IW. Pushing the envelope: Structure, function, and dynamics of the nuclear periphery. Annual Review of Cell and Developmental Biology. 2005;21:347-380. doi:10.1146/annurev.cellbio.21.090704.151152
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[7]
2003 | Journal Article | IST-REx-ID: 11122
Walther TC, Alves A, Pickersgill H, et al. The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell. 2003;113(2):195-206. doi:10.1016/s0092-8674(03)00235-6
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[6]
2003 | Journal Article | IST-REx-ID: 11121
Walther TC, Askjaer P, Gentzel M, et al. RanGTP mediates nuclear pore complex assembly. Nature. 2003;424(6949):689-694. doi:10.1038/nature01898
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[5]
2002 | Journal Article | IST-REx-ID: 11124 | OA
Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. Ran binds to chromatin by two distinct mechanisms. Current Biology. 2002;12(13):1151-1156. doi:10.1016/s0960-9822(02)00927-2
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[4]
2002 | Journal Article | IST-REx-ID: 11123
Hetzer M, Gruss OJ, Mattaj IW. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Nature Cell Biology. 2002;4(7):E177-E184. doi:10.1038/ncb0702-e177
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[3]
2001 | Journal Article | IST-REx-ID: 11125
Hetzer M, Meyer HH, Walther TC, Bilbao-Cortes D, Warren G, Mattaj IW. Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Nature Cell Biology. 2001;3(12):1086-1091. doi:10.1038/ncb1201-1086
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[2]
2000 | Journal Article | IST-REx-ID: 11126
Hetzer M, Mattaj IW. An Atp-dependent, Ran-independent mechanism for nuclear import of the U1a and U2b′′ spliceosome proteins. Journal of Cell Biology. 2000;148(2):293-304. doi:10.1083/jcb.148.2.293
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[1]
2000 | Journal Article | IST-REx-ID: 11127 | OA
Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. GTP hydrolysis by Ran is required for nuclear envelope assembly. Molecular Cell. 2000;5(6):1013-1024. doi:10.1016/s1097-2765(00)80266-x
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[79]
2024 | Journal Article | IST-REx-ID: 15316
Zocher S, Mccloskey A, Karasinsky A, et al. Lifelong persistence of nuclear RNAs in the mouse brain. Science. 2024;384(6691):53-59. doi:10.1126/science.adf3481
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[78]
2023 | Journal Article | IST-REx-ID: 12880 | OA
Kaneshiro JM, Capitanio JS, Hetzer M. Lamin B1 overexpression alters chromatin organization and gene expression. Nucleus. 2023;14(1). doi:10.1080/19491034.2023.2202548
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[77]
2023 | Journal Article | IST-REx-ID: 14315 | OA
Cho UH, Hetzer M. Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress. eLife. 2023;12. doi:10.7554/eLife.89066
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[76]
2022 | Journal Article | IST-REx-ID: 11051
Liu J, Hetzer M. Nuclear pore complex maintenance and implications for age-related diseases. Trends in Cell Biology. 2022;32(3):P216-227. doi:10.1016/j.tcb.2021.10.001
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[75]
2021 | Journal Article | IST-REx-ID: 11053 | OA
Shadel GS, Adams PD, Berggren WT, et al. The San Diego Nathan Shock Center: Tackling the heterogeneity of aging. GeroScience. 2021;43(5):2139-2148. doi:10.1007/s11357-021-00426-x
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[74]
2021 | Journal Article | IST-REx-ID: 11052
Krishna S, Arrojo e Drigo R, Capitanio JS, Ramachandra R, Ellisman M, Hetzer M. Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain. Developmental Cell. 2021;56(21):P2952-2965.e9. doi:10.1016/j.devcel.2021.10.008
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[73]
2020 | Journal Article | IST-REx-ID: 11056 | OA
Bersini S, Arrojo e Drigo R, Huang L, Shokhirev MN, Hetzer M. Transcriptional and functional changes of the human microvasculature during physiological aging and Alzheimer disease. Advanced Biosystems. 2020;4(5). doi:10.1002/adbi.202000044
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[72]
2020 | Journal Article | IST-REx-ID: 11055 | OA
Bersini S, Schulte R, Huang L, Tsai H, Hetzer M. Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. eLife. 2020;9. doi:10.7554/elife.54383
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[71]
2020 | Journal Article | IST-REx-ID: 11054 | OA
Cho UH, Hetzer M. Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging. Neuron. 2020;106(6):899-911. doi:10.1016/j.neuron.2020.05.031
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[70]
2020 | Journal Article | IST-REx-ID: 11057 | OA
Kang H, Shokhirev MN, Xu Z, Chandran S, Dixon JR, Hetzer M. Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation. Genes & Development. 2020;34(13-14):913-930. doi:10.1101/gad.335794.119
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[69]
2020 | Journal Article | IST-REx-ID: 11058 | OA
Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer M. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life Science Alliance. 2020;3(1). doi:10.26508/lsa.201900623
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[68]
2019 | Journal Article | IST-REx-ID: 11061 | OA
Toyama BH, Arrojo e Drigo R, Lev-Ram V, et al. Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells. Journal of Cell Biology. 2019;218(2):433-444. doi:10.1083/jcb.201809123
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[67]
2019 | Journal Article | IST-REx-ID: 11062 | OA
Arrojo e Drigo R, Lev-Ram V, Tyagi S, et al. Age mosaicism across multiple scales in adult tissues. Cell Metabolism. 2019;30(2):343-351.e3. doi:10.1016/j.cmet.2019.05.010
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[66]
2019 | Journal Article | IST-REx-ID: 11059
Buchwalter A, Kaneshiro JM, Hetzer M. Coaching from the sidelines: The nuclear periphery in genome regulation. Nature Reviews Genetics. 2019;20(1):39-50. doi:10.1038/s41576-018-0063-5
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[65]
2019 | Journal Article | IST-REx-ID: 11060 | OA
Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. eLife. 2019;8. doi:10.7554/elife.49796
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[64]
2019 | Research Data Reference | IST-REx-ID: 13079 | OA
Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. Data from: Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. 2019. doi:10.5061/DRYAD.N0R525H
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[63]
2018 | Journal Article | IST-REx-ID: 11063 | OA
McCloskey A, Ibarra A, Hetzer M. Tpr regulates the total number of nuclear pore complexes per cell nucleus. Genes & Development. 2018;32(19-20):1321-1331. doi:10.1101/gad.315523.118
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[62]
2018 | Journal Article | IST-REx-ID: 11064 | OA
Fleischer JG, Schulte R, Tsai HH, et al. Predicting age from the transcriptome of human dermal fibroblasts. Genome Biology. 2018;19. doi:10.1186/s13059-018-1599-6
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[61]
2017 | Journal Article | IST-REx-ID: 11066 | OA
Franks TM, McCloskey A, Shokhirev MN, Benner C, Rathore A, Hetzer M. Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. Genes & Development. 2017;31(22):2222-2234. doi:10.1101/gad.306753.117
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[60]
2017 | Journal Article | IST-REx-ID: 11067 | OA
Toda T, Hsu JY, Linker SB, et al. Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. Cell Stem Cell. 2017;21(5):618-634.e7. doi:10.1016/j.stem.2017.08.012
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[59]
2017 | Journal Article | IST-REx-ID: 11065 | OA
Buchwalter A, Hetzer M. Nucleolar expansion and elevated protein translation in premature aging. Nature Communications. 2017;8. doi:10.1038/s41467-017-00322-z
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[58]
2016 | Journal Article | IST-REx-ID: 11072 | OA
van de Ven RAH, de Groot JS, Park D, et al. p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis. Nature Communications. 2016;7. doi:10.1038/ncomms13874
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[57]
2016 | Journal Article | IST-REx-ID: 11071 | OA
Franks TM, Benner C, Narvaiza I, et al. Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes & Development. 2016;30(10):1155-1171. doi:10.1101/gad.280941.116
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[56]
2016 | Journal Article | IST-REx-ID: 11069 | OA
Hatch EM, Hetzer M. Nuclear envelope rupture is induced by actin-based nucleus confinement. Journal of Cell Biology. 2016;215(1):27-36. doi:10.1083/jcb.201603053
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[55]
2016 | Journal Article | IST-REx-ID: 11070 | OA
Ibarra A, Benner C, Tyagi S, Cool J, Hetzer M. Nucleoporin-mediated regulation of cell identity genes. Genes & Development. 2016;30(20):2253-2258. doi:10.1101/gad.287417.116
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[54]
2015 | Journal Article | IST-REx-ID: 11079 | OA
Mertens J, Paquola ACM, Ku M, et al. Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects. Cell Stem Cell. 2015;17(6):705-718. doi:10.1016/j.stem.2015.09.001
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[53]
2015 | Journal Article | IST-REx-ID: 11077 | OA
Jacinto FV, Benner C, Hetzer M. The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes & Development. 2015;29(12):1224-1238. doi:10.1101/gad.260919.115
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[52]
2015 | Journal Article | IST-REx-ID: 11078 | OA
Ori A, Toyama BH, Harris MS, et al. Integrated transcriptome and proteome analyses reveal organ-specific proteome deterioration in old rats. Cell Systems. 2015;1(3):P224-237. doi:10.1016/j.cels.2015.08.012
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[51]
2015 | Journal Article | IST-REx-ID: 11075
Gomez-Cavazos JS, Hetzer M. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. Journal of Cell Biology. 2015;208(6):671-681. doi:10.1083/jcb.201410047
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[50]
2015 | Journal Article | IST-REx-ID: 11076 | OA
Ibarra A, Hetzer M. Nuclear pore proteins and the control of genome functions. Genes & Development. 2015;29(4):337-349. doi:10.1101/gad.256495.114
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[49]
2015 | Journal Article | IST-REx-ID: 11073 | OA
Hatch EM, Hetzer M. Linking micronuclei to chromosome fragmentation. Cell. 2015;161(7):1502-1504. doi:10.1016/j.cell.2015.06.005
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[48]
2015 | Journal Article | IST-REx-ID: 11074 | OA
Hatch EM, Hetzer M. Chromothripsis. Current Biology. 2015;25(10):PR397-R399. doi:10.1016/j.cub.2015.02.033
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[47]
2014 | Journal Article | IST-REx-ID: 11080 | OA
Buchwalter A, Hetzer M. Nuclear pores set the speed limit for mitosis. Cell. 2014;156(5):868-869. doi:10.1016/j.cell.2014.02.004
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[46]
2014 | Journal Article | IST-REx-ID: 11082 | OA
Buchwalter AL, Liang Y, Hetzer M. Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Molecular Biology of the Cell. 2014;25(16):2472-2484. doi:10.1091/mbc.e14-04-0865
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[45]
2014 | Journal Article | IST-REx-ID: 11081 | OA
Hatch E, Hetzer M. Breaching the nuclear envelope in development and disease. Journal of Cell Biology. 2014;205(2):133-141. doi:10.1083/jcb.201402003
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[44]
2013 | Journal Article | IST-REx-ID: 11086 | OA
Liang Y, Franks TM, Marchetto MC, Gage FH, Hetzer M. Dynamic association of NUP98 with the human genome. PLoS Genetics. 2013;9(2). doi:10.1371/journal.pgen.1003308
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[43]
2013 | Journal Article | IST-REx-ID: 11087 | OA
Toyama BH, Savas JN, Park SK, et al. Identification of long-lived proteins reveals exceptional stability of essential cellular structures. Cell. 2013;154(5):971-982. doi:10.1016/j.cell.2013.07.037
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[42]
2013 | Journal Article | IST-REx-ID: 11085 | OA
Hatch EM, Fischer AH, Deerinck TJ, Hetzer M. Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell. 2013;154(1):47-60. doi:10.1016/j.cell.2013.06.007
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[41]
2013 | Journal Article | IST-REx-ID: 11088 | OA
Regner BM, Vučinić D, Domnisoru C, et al. Anomalous diffusion of single particles in cytoplasm. Biophysical Journal. 2013;104(8):1652-1660. doi:10.1016/j.bpj.2013.01.049
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[40]
2013 | Journal Article | IST-REx-ID: 11083
Franks TM, Hetzer M. The role of Nup98 in transcription regulation in healthy and diseased cells. Trends in Cell Biology. 2013;23(3):112-117. doi:10.1016/j.tcb.2012.10.013
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[39]
2013 | Journal Article | IST-REx-ID: 11084
Toyama BH, Hetzer M. Protein homeostasis: Live long, won’t prosper. Nature Reviews Molecular Cell Biology. 2013;14:55-61. doi:10.1038/nrm3496
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[38]
2012 | Journal Article | IST-REx-ID: 11089
Gomez-Cavazos JS, Hetzer M. Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins. Current Opinion in Cell Biology. 2012;24(6):775-783. doi:10.1016/j.ceb.2012.08.008
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[37]
2012 | Journal Article | IST-REx-ID: 11091
Vargas JD, Hatch EM, Anderson DJ, Hetzer M. Transient nuclear envelope rupturing during interphase in human cancer cells. Nucleus. 2012;3(1):88-100. doi:10.4161/nucl.18954
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[36]
2012 | Journal Article | IST-REx-ID: 11093 | OA
D’Angelo MA, Gomez-Cavazos JS, Mei A, Lackner DH, Hetzer M. A change in nuclear pore complex composition regulates cell differentiation. Developmental Cell. 2012;22(2):446-458. doi:10.1016/j.devcel.2011.11.021
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[35]
2012 | Journal Article | IST-REx-ID: 11092
Savas JN, Toyama BH, Xu T, Yates JR, Hetzer M. Extremely long-lived nuclear pore proteins in the rat brain. Science. 2012;335(6071):942-942. doi:10.1126/science.1217421
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[34]
2012 | Journal Article | IST-REx-ID: 11090 | OA
Hatch EM, Hetzer M. RNP export by nuclear envelope budding. Cell. 2012;149(4):733-735. doi:10.1016/j.cell.2012.04.018
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[33]
2011 | Journal Article | IST-REx-ID: 11094 | OA
Talamas JA, Hetzer M. POM121 and Sun1 play a role in early steps of interphase NPC assembly. Journal of Cell Biology. 2011;194(1):27-37. doi:10.1083/jcb.201012154
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[32]
2011 | Journal Article | IST-REx-ID: 11096
Liang Y, Hetzer M. Functional interactions between nucleoporins and chromatin. Current Opinion in Cell Biology. 2011;23(1):65-70. doi:10.1016/j.ceb.2010.09.008
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[31]
2011 | Journal Article | IST-REx-ID: 11095
Hetzer M, Cavalli G. Editorial overview. Current Opinion in Cell Biology. 2011;23(3):255-257. doi:10.1016/j.ceb.2011.04.013
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[30]
2011 | Journal Article | IST-REx-ID: 11100
Capelson M, Doucet C, Hetzer M. Nuclear pore complexes: Guardians of the nuclear genome. Cold Spring Harbor Symposia on Quantitative Biology. 2011;75:585-597. doi:10.1101/sqb.2010.75.059
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[29]
2010 | Journal Article | IST-REx-ID: 11097
Hetzer M. The nuclear envelope. Cold Spring Harbor Perspectives in Biology. 2010;2(3):a000539-a000539. doi:10.1101/cshperspect.a000539
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[28]
2010 | Journal Article | IST-REx-ID: 11099
Doucet CM, Hetzer M. Nuclear pore biogenesis into an intact nuclear envelope. Chromosoma. 2010;119:469-477. doi:10.1007/s00412-010-0289-2
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[27]
2010 | Journal Article | IST-REx-ID: 11102 | OA
Capelson M, Liang Y, Schulte R, Mair W, Wagner U, Hetzer M. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Cell. 2010;140(3):372-383. doi:10.1016/j.cell.2009.12.054
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[26]
2010 | Journal Article | IST-REx-ID: 11101 | OA
Doucet CM, Talamas JA, Hetzer M. Cell cycle-dependent differences in nuclear pore complex assembly in metazoa. Cell. 2010;141(6):1030-1041. doi:10.1016/j.cell.2010.04.036
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[25]
2010 | Journal Article | IST-REx-ID: 11098 | OA
Hetzer M. The role of the nuclear pore complex in aging of post-mitotic cells. Aging. 2010;2(2):74-75. doi:10.18632/aging.100125
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[24]
2009 | Journal Article | IST-REx-ID: 11103 | OA
Hetzer M, Wente SR. Border control at the nucleus: Biogenesis and organization of the nuclear membrane and pore complexes. Developmental Cell. 2009;17(5):606-616. doi:10.1016/j.devcel.2009.10.007
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[23]
2009 | Journal Article | IST-REx-ID: 11106 | OA
Anderson DJ, Vargas JD, Hsiao JP, Hetzer M. Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo. Journal of Cell Biology. 2009;186(2):183-191. doi:10.1083/jcb.200901106
[Published Version] View | Files available | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[22]
2009 | Journal Article | IST-REx-ID: 11107 | OA
Dawson TR, Lazarus MD, Hetzer M, Wente SR. ER membrane–bending proteins are necessary for de novo nuclear pore formation. Journal of Cell Biology. 2009;184(5):659-675. doi:10.1083/jcb.200806174
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[21]
2009 | Journal Article | IST-REx-ID: 11108 | OA
D’Angelo MA, Raices M, Panowski SH, Hetzer M. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell. 2009;136(2):284-295. doi:10.1016/j.cell.2008.11.037
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[20]
2009 | Journal Article | IST-REx-ID: 11105 | OA
Capelson M, Hetzer M. The role of nuclear pores in gene regulation, development and disease. EMBO reports. 2009;10(7):697-705. doi:10.1038/embor.2009.147
[Published Version] View | Files available | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[19]
2008 | Journal Article | IST-REx-ID: 11111
Anderson DJ, Hetzer M. Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation. Journal of Cell Biology. 2008;182(5):911-924. doi:10.1083/jcb.200805140
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[18]
2008 | Journal Article | IST-REx-ID: 11110
D’Angelo MA, Hetzer M. Structure, dynamics and function of nuclear pore complexes. Trends in Cell Biology. 2008;18(10):456-466. doi:10.1016/j.tcb.2008.07.009
View | DOI | PubMed | Europe PMC
 
[17]
2008 | Journal Article | IST-REx-ID: 11109
Kutay U, Hetzer M. Reorganization of the nuclear envelope during open mitosis. Current Opinion in Cell Biology. 2008;20(6):669-677. doi:10.1016/j.ceb.2008.09.010
View | DOI | PubMed | Europe PMC
 
[16]
2008 | Journal Article | IST-REx-ID: 11112
Anderson DJ, Hetzer M. The life cycle of the metazoan nuclear envelope. Current Opinion in Cell Biology. 2008;20(4):386-392. doi:10.1016/j.ceb.2008.03.016
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[15]
2008 | Journal Article | IST-REx-ID: 11113 | OA
Anderson DJ, Hetzer M. Shaping the endoplasmic reticulum into the nuclear envelope. Journal of Cell Science. 2008;121(2):137-142. doi:10.1242/jcs.005777
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[14]
2008 | Journal Article | IST-REx-ID: 11114 | OA
Schulte R, Talamas J, Doucet C, Hetzer M. Single bead affinity detection (SINBAD) for the analysis of protein-protein interactions. PLoS ONE. 2008;3(4). doi:10.1371/journal.pone.0002061
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[13]
2007 | Journal Article | IST-REx-ID: 11116 | OA
Franz C, Walczak R, Yavuz S, et al. MEL‐28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. EMBO reports. 2007;8(2):165-172. doi:10.1038/sj.embor.7400889
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[12]
2007 | Journal Article | IST-REx-ID: 11115
Anderson DJ, Hetzer M. Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum. Nature Cell Biology. 2007;9(10):1160-1166. doi:10.1038/ncb1636
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[11]
2006 | Book Chapter | IST-REx-ID: 11119
Harris JR, Almouzni G, Kirschner D, Dimitrova D, Nickerson JA, Underwood J, Wagner S, Korbei B, Foisner R, Walther TC, Hetzer M, Peters R, Walev I, de Kroon AIPM, Staffhorst RWHM, de Kruijff B, Burger KNJ, Netto LES, Bertrand E, Alimonti JB, Greenberg AH, Xiao J, Pradhan A, Liu Y, Paiement J, Young R, Goñi FM, Villar A-V, Contreras F-X, Alonso A, Peter BJ, Mills IG, Higgins MK, Brown WJ, Chambers K, Doody A, Cheng CY, Mruk DD, Yang C, Kirchhoff H, Haase W, Boggasch S, Paulsen H, Benesova J, Liffers S-T, Rögner M, Gao Y, Sztul E, Thiemann M, Fahimi HD, Gniadecki R, Gajkowska B, Bane SL, Hess JF, Voss JC, Fitzgerald PG, Hisanaga S, Sasaki T, Uéda K, Town T, Tan J, Milton NGN, Chi R, Keller TCS, Kriajevska M, Bronstein I, Lukanidin E, Holmes DF, Kadler KE. 2006.In Vitro Techniques. In: Cell Biology Protocols. , 201–378.
View | DOI
 
[10]
2006 | Journal Article | IST-REx-ID: 11117
D’Angelo MA, Hetzer M. The role of the nuclear envelope in cellular organization. Cellular and Molecular Life Sciences. 2006;63(3):316-332. doi:10.1007/s00018-005-5361-3
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[9]
2006 | Journal Article | IST-REx-ID: 11118
D’Angelo MA, Anderson DJ, Richard E, Hetzer M. Nuclear pores form de novo from both sides of the nuclear envelope. Science. 2006;312(5772):440-443. doi:10.1126/science.1124196
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[8]
2005 | Journal Article | IST-REx-ID: 11120
Hetzer M, Walther TC, Mattaj IW. Pushing the envelope: Structure, function, and dynamics of the nuclear periphery. Annual Review of Cell and Developmental Biology. 2005;21:347-380. doi:10.1146/annurev.cellbio.21.090704.151152
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[7]
2003 | Journal Article | IST-REx-ID: 11122
Walther TC, Alves A, Pickersgill H, et al. The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell. 2003;113(2):195-206. doi:10.1016/s0092-8674(03)00235-6
[Published Version] View | DOI | PubMed | Europe PMC
 
[6]
2003 | Journal Article | IST-REx-ID: 11121
Walther TC, Askjaer P, Gentzel M, et al. RanGTP mediates nuclear pore complex assembly. Nature. 2003;424(6949):689-694. doi:10.1038/nature01898
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[5]
2002 | Journal Article | IST-REx-ID: 11124 | OA
Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. Ran binds to chromatin by two distinct mechanisms. Current Biology. 2002;12(13):1151-1156. doi:10.1016/s0960-9822(02)00927-2
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
[4]
2002 | Journal Article | IST-REx-ID: 11123
Hetzer M, Gruss OJ, Mattaj IW. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Nature Cell Biology. 2002;4(7):E177-E184. doi:10.1038/ncb0702-e177
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[3]
2001 | Journal Article | IST-REx-ID: 11125
Hetzer M, Meyer HH, Walther TC, Bilbao-Cortes D, Warren G, Mattaj IW. Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Nature Cell Biology. 2001;3(12):1086-1091. doi:10.1038/ncb1201-1086
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[2]
2000 | Journal Article | IST-REx-ID: 11126
Hetzer M, Mattaj IW. An Atp-dependent, Ran-independent mechanism for nuclear import of the U1a and U2b′′ spliceosome proteins. Journal of Cell Biology. 2000;148(2):293-304. doi:10.1083/jcb.148.2.293
View | DOI | PubMed | Europe PMC
 
[1]
2000 | Journal Article | IST-REx-ID: 11127 | OA
Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. GTP hydrolysis by Ran is required for nuclear envelope assembly. Molecular Cell. 2000;5(6):1013-1024. doi:10.1016/s1097-2765(00)80266-x
[Published Version] View | DOI | Download Published Version (ext.) | PubMed | Europe PMC
 
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